<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02137

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAVAKQQELQTAVRYWSDFISKCISQRLDTDQFRDYVRLVHAKYPLRPVAIADFILRPQPSNNVSLDPRIPPYIQVLSQLGYIDAPSILRALYKHSALHAATPGDGKDGDKAKARWKSSSWAEEIMFYHVIKTVVEGSGFKDALGALELVDVICKWMHLFVAASNATALDALQAREEMEIARAAFVPLLLRVVDNVYLLKVLAQPTSKALRKLLSDSLASFIPILQPVPQFAEKLEVFRTETLAQMDPIDKKSSAAANAAMDELLDSTVGSENFVIPEIAISTTRTGLFVYLSASLIGRPILDDHTLFSYLNNRHQGNTQASAIDLILASFDVLASAAWKKPNSNDGNLLRSYLVNKVPLLLCQLVPPEFSTTTSEFCITEALNQLDNNVFPTASLMFDSIQESNQHTDSVREEFCSACALHGLIDRGHVDRILGELSMAYNPNLQKQSKETLVQECLTDPSKIQGLLLELEKMDGNVGAVCQALVELIRQLCNNKETMTLKLLCSQLAQKPQSLDILLLFEKLPAIMAPLCQLLDGWKYDDDQTEYQPVYDEFGSILLLVLAFAYRYKVSSTTLGAPSNDSAIARIINKSHASRSLDDLSEQEKNHVNGWIQGLFDSDAGGLGDDLMSSCPPGDFYQLIGTIFQSIVTAHAHGYVNEETLKGGFEYLADTFLLPCLAPAMLFLADYLWVDQKEQKSIIKILHMAMTPSSNQEANIMLISVKNLIAQPLTHALRTYQREDPRNQEVEPLIESLRENVPLSRRTGCAENTELEKWANSSSAGLTGALRQTMQSLIQWSLQSGTSSPPPDYTHRKLVAGVKIIGARRLLRLIVDEVRQQTDAGHAGAAYDLAVALIAAPDVTAGPTSASSPLDLRGALKAEADDWKITQKKDAQRAEIIVRLHRKVEAQLLIPPPEPILQDAEMTLIAADATQLDDAITAAVDDTMAVDASVLDASALDATALDLALEPVTEGDLFDLEGTIDVFDGWDSMDLGGGDL
Length996
PositionTail
OrganismTorrubiella hemipterigena
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Torrubiella.
Aromaticity0.07
Grand average of hydropathy-0.055
Instability index41.06
Isoelectric point4.86
Molecular weight109499.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02137
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.74|      11|      26|     926|     936|       1
---------------------------------------------------------------------------
  926-  936 (19.42/11.16)	AADATQLDDAI
  955-  965 (18.32/10.08)	ALDATALDLAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.04|      21|      25|     598|     618|       2
---------------------------------------------------------------------------
  598-  618 (38.73/24.85)	DDL.SEQEKNHVNGWIQGLFDS
  625-  646 (35.31/22.00)	DDLmSSCPPGDFYQLIGTIFQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.56|      16|      25|     843|     860|       3
---------------------------------------------------------------------------
  843-  858 (26.77/18.30)	AGAAYDLAVALIAAPD
  866-  881 (26.79/11.40)	ASSPLDLRGALKAEAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.60|      38|      86|     383|     420|       4
---------------------------------------------------------------------------
  376-  413 (61.61/44.69)	EFCITEA.......LNQL.D....NNVFPTASLMFDS.IQE..SNQHTDSVRE
  414-  456 (45.17/30.64)	EFCSACA.......LHGLiDrghvDRILGELSMAYNPnLQK..QSKET.LVQE
  457-  502 (38.81/25.20)	CLTDPSKiqgllleLEKM.D....GNVGAVCQALVEL.IRQlcNNKETMTLK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.79|      20|      27|     728|     752|       5
---------------------------------------------------------------------------
  728-  752 (26.36/29.58)	PLTHalRTYQREdprNQEVEPLIES
  758-  777 (36.43/22.03)	PLSR..RTGCAE...NTELEKWANS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.24|      25|      40|     289|     314|       6
---------------------------------------------------------------------------
  289-  314 (41.63/36.56)	F.VYLSASLiGRPILDDHTLF.SYLNNR
  331-  357 (36.61/26.12)	FdVLASAAW.KKPNSNDGNLLrSYLVNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.68|      25|      26|     199|     224|      12
---------------------------------------------------------------------------
  198-  223 (34.94/32.44)	LLKVLAQPTSKaLRKLLSDSLASFIP
  224-  248 (42.73/34.36)	ILQPVPQFAEK.LEVFRTETLAQMDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02137 with Med5 domain of Kingdom Fungi
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