<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02130

Description Putative Mediator of RNA polymerase II transcription subunit 12
SequenceMNSQSRSHQRVPSSGSSVRVPSLAHQISKPQPATSSPALSRKDTPVARSDTSDMSQNNGVSTPMRVASRLRQEIPHEASLDSLSTTASPQTATPSRLTHVSDSIEIINDSPAPSQLSQHDVDNPPMPLPRRRAPLLHRIPSYRIAAPPTSVKRDSRPKQYSIETPSDAPRYISANKSDPVYRDPFSRSLFSGNADFFPWNGSHHEDEWSAEAIQKGTWDRGSQNETSSARFAVMPALKQKTGLSALSTIFMGVLNQRRNSGQITAPSTFKPPPRVTVTDTKREVWLKDLANPAISLRRLSRTIPHGIRGKTLLEQCLNKNVPTERAIWLAKCVGANDIRALNRKGVNGAFAMGGELKWIRDWTIFVEQFVETVVSGFTELDWKHRVVYATRLATVLYAEHLLDRDHYLDWITSSLEASPQSKIPMWIIIAQICWKDLLRSRKHGRRLVFAMLGHLHSIYQDPDRDIVIQLSSQLSTLLSTLLKNHPENFLYPSLWSRYRDSLKIAIGPENSDLQASFNAVDSRNRQLVFAGNTSSPSGYQYLVKLLDSTLIGPAEHNFAVNCWSSLDDKARVVKTVVEWATSSHRPGVSKIYTASNLLREWSTQRINPTTSILELLDGIPTADSVRKQLLYHLVAELCRSGHFSLSQYIQWLIARGSCRDSADIDPVSGPCASRLLAELPMYCFSDEGSQNRANLLRRAGSYDVAEEAEDIATAKRYLRETIGLPLMEGDDSNTTPRVIPLKKLLSKIKSSSMALKCDVGAALRTDLSNMDNTSLDSTLSLNMFISLRSVFEVTGDFAMLVDVLKACTRSSNVDVLAACADTINVHLVTFLALNQAEELFDGLLNRLKVFARDQGVVVRPFLASLALLAAKMPDRDAVTSNLQQELAHSDKNSAIDACSPVSDNMVGQSAEGEVSEQIDRLLASGTSVDVPTMNRLFRNIFPRLESGWGKLDDSRRVFASLLSRLRVFDSQHFDKLMADWVSHIRLLPERQPLYELFPMLLSLGCLTVSTMLQTASPAPSQIPSAADATKGSASYLQEVLQLMTGKLPKDTPLTPDELYRFQSIQASGAIEHSKLFLQVIRNTILEYSALKSHDASIARPLDENANMKNLLAVLRLLVIVDAATVSDALKVNDMPTNASAFIRQIVSKLLSPHDETNTPPSFDQILSQANELTMPFCQLSLNMELTFGQLIEAEGDEGKQSQFDVFARAMDSAIDAKNIMWTSMLPCLNEDITQHLKSQAYYRFFDLVPSSKSDDFATALLNQDRIQLATNLLGVIEAIISGQPSSKSGQLTSAIVDKLTDVWEALANTDTELTAASTDALLQSWLPVLLRFISLHGNVPELTAAATTPGAASGIRPALSINLEARARTILLLCGIIFELEARYAETTSELVQQIFDIAVLLVDALPDDLRNHCAKAIIAAPTPTPSKSATSDRRIYYLFSVQPATLADNLMLAHRDKASLPHSAAARGLGAMYGIGPTTQERFTPFILRRWEVLSEPTPNVGENDTSLSLGLFEAIKIQ
Length1520
PositionKinase
OrganismTorrubiella hemipterigena
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Torrubiella.
Aromaticity0.07
Grand average of hydropathy-0.185
Instability index43.56
Isoelectric point6.50
Molecular weight167834.13
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02130
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     796.83|     278|     309|     610|     918|       1
---------------------------------------------------------------------------
  610-  918 (397.70/264.63)	TSIlellDgIPTADSVRKQLLYHLVAELcrsGHFSLSQYI.QWLIARGSCRDSADIDPVSGPCAS..RLLAE.LPMY.CFS...DEGSQNRANLLRRA..GSYDVAEEAEDIATAKRYLRETigLPLMEGDDSNTTPrVIP..LKKLLS.....KIKSSSMALKCDVGAALR.TDLSNMDnTSLDSTLSLNmfISLRSVFEVtgdFAMLVdVLKACTRSSNVDV..LAACADTINVHLVTFLaLNQAEEL.....FDGLLNRlkvfARDqgvVVRPF..LA.SLALLAAKMPDRDAVTSNLQQ.ELAHSDKNSAIDAcspvsDNMVGQSAEGEVSEQI
  926- 1232 (399.13/200.68)	TSV....D.VPTMNRLFRNIFPRLESGW...GKLDDSRRVfASLLSRLRVFDSQHFDKLMADWVShiRLLPErQPLYeLFPmllSLGCLTVSTMLQTAspAPSQIPSAADATKGSASYLQEV..LQLMTGKLPKDTP.LTPdeLYRFQSiqasgAIEHSKLFLQVIRNTILEySALKSHD.ASIARPLDEN..ANMKNLLAV...LRLLV.IVDAATVSDALKVndMPTNASAFIRQIVSKL.LSPHDETntppsFDQILSQ....ANE...LTMPFcqLSlNMELTFGQLIEAEGDEGKQSQfDVFARAMDSAIDA.....KNIMWTSMLPCLNEDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.97|      24|      31|       7|      30|       2
---------------------------------------------------------------------------
    7-   30 (39.79/20.69)	SHQRVPSSGSSVRVPSLAHQISKP
   40-   63 (38.98/20.13)	SRKDTPVARSDTSDMSQNNGVSTP
   70-   89 (32.19/15.37)	LRQEIPHEAS...LDSLSTTAS.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.13|      19|      59|     103|     124|       3
---------------------------------------------------------------------------
  103-  124 (25.81/22.47)	SIEIINDspAPSQLSQHDVDnP
  161-  179 (35.32/18.21)	SIETPSD..APRYISANKSD.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.24|      30|      67|     474|     504|       5
---------------------------------------------------------------------------
  474-  504 (48.62/37.58)	LSTLL.STLLKNHPENFLYpSLWSRYRDSLKI
  542-  572 (48.62/31.80)	LVKLLdSTLIGPAEHNFAV.NCWSSLDDKARV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     281.13|      69|    1015|     246|     341|       6
---------------------------------------------------------------------------
  246-  314 (114.55/59.43)	LSTIFMGVL.NQRRN...SGQITAPSTFKPPPRVTVTDTKREVWL.....KDLANPAISLRRLSRTIPHGIRGKTLLE
 1268- 1331 (93.35/45.04)	LATNLLGVI.EAII....SGQ...PSSKSGQLTSAIVDKLTDVW......EALANTDTELTAASTDALLQSWLPVLLR
 1398- 1470 (73.22/52.22)	IAVLLVDALpDDLRNhcaKAIIAAPT...PTPSKSATSDRRIYYLfsvqpATLADNLMLAHRDKASLPHSAAARGL..
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02130 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNSQSRSHQRVPSSGSSVRVPSLAHQISKPQPATSSPALSRKDTPVARSDTSDMSQNNGVSTPMRVASRLRQEIPHEASLDSLSTTASPQTATPSRLTHVSDSIEIINDSPAPSQLSQHDVDNPPMPLPRRRAPLLHRIPSYRIAAPPTSVKRDSRPKQYSIETPSDAPRYISANKS
1
177










Molecular Recognition Features






MoRF SequenceStartStop




1) RRIYYLF
2) RRRAPLLHRIPSYRIAAPPTSV
1434
130
1440
151