<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02129

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTGEYETNALIVNDVSAIAYRLYEPAQDHRFNFHSFGLNVEKALREQRHIVSYDAKERAIWYFYVLPKDDELDTTANEKLGPTIQILDCALQIREEGVFEPGFLHKSRLQTQQSTQTINSTATPTASASDSQRHGLNSPSQLSVTTPQDHESKASNLSQQETNSPHITDKLVYENFIGALLYTVSSTFCTRTQSLPLNYRTVLLPEAFCQVQDYSNADPSLQPRLGSFRAYITTTGALIIGFTVTVCRGFECLSQAISSSSNGMATKVLAAPFGIVKGRDGSPTSDLGIEHPSSNQSQALRSLSGTHLALWEQACFNILQSRGVSNQAIGTESWATLSINKLRLQEARTEEKRNNEPCPTFSMPWPGKLCFRKKVLDVSSTNRVGEMIISVHDESHDPLALARTWFNASAEREEKLSRRRSDRRTAQAADAQGQDPRLSRPNAPSPLAMRQQGASGANMVYPTPPDALHNLNGVTPTLDGALSSPGNPLSAANVDIDAAPSASHVINSGEEEAHSEAGDSKRLNSDVNLLNGADNIFEDMGGDMFDDNDITEADFNFFDEEPSAMEMEPHDEKPLDKDDLDGTPRVEHNTDVTAAPEQSVSIKEEPVVFAKPELRHARSSQVDENQRGKENSFGKTLKRSSSPFDPHTIFKRVRASILLSRAAAAQNVNNLQRAGKIFEKVDFDHRLPMLNKKYEHGGLYDYGDVGRRASLKSEPGAVPQTNYLKRHGKGLLKRNARPNSLDSLMGSLGGIDGLTADVGVGKYNNMTAAGDESSSDSDSDESYADIGGDPSPLKTGFRSTVNGPADSDAVSQGTPVRDAEPLNEADDRLALELPRLLRPDTPEISLPQYFADPEPFPLDLPLSDEDLILVAQLVTEQAAIGALDIYDHRSEESYDDDAACQRPPYFATRGSIDILQHIVSSFLSRATSLKLKALLDIQDIPLMGQPARVQPRAIPGRDPNSDPVRPSNLYQIPSPHLEVRRADNKLSVLPSAIGFWESLGLAPSSGNKDVNAVCVFQGWTGMADNVRTFLGRLKSMYETLKLGSVQNMPIADQEAGMLQYEVDKISTSPDATMTGHGSAMIESMETLRGALSSLETVDTNVVVYFVYSPRNPGTIVEACTAFQRFFDSYQASLTAKQEIPKNELVLQLVSADLISSPSKVIVTPAADLVRLCMETYDRCVPFGGTMPAPAIRLEQPLPRIIDFKLNNNPSASLIRENSCIHVAYATSVDKRWISAAWTDDRGNEQATASYCFGRKDKSPSRTMNDIANEIWESTLQLISTWKIHWRVVITKCGPMEAHEAEFWIELARTEIHASVTMILMTVDTKPSLQLIPPAIKLPPQSITSYTTPVSTPQPNIVSPEAMATPATPARDASTLAATPGGDSTADPETESVLADVTDQTWGAISSHRLSNSISTLETHPAFISGYLVKRTGSKAEDSPAIMEVNLVHTEAGSRAYEPLLREMLSYFRSLGTLARARGVVEAETDVRPWHVAAAEKAARALYLLM
Length1506
PositionKinase
OrganismTorrubiella hemipterigena
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Torrubiella.
Aromaticity0.06
Grand average of hydropathy-0.409
Instability index47.94
Isoelectric point5.15
Molecular weight164876.69
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02129
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.38|      18|     139|     527|     544|       1
---------------------------------------------------------------------------
  527-  544 (33.14/17.69)	DVNLLNGADNIFEDMGGD
  668-  685 (32.24/17.05)	NVNNLQRAGKIFEKVDFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     366.09|      77|     270|     440|     524|       2
---------------------------------------------------------------------------
  440-  517 (126.10/69.81)	SRPNA.PSPLAMRQQGASGAnMVYPTPP..DALHNLNGVTPTLDGALSSPGNP.LSAANV.DIDAAPSASHVI.NSGEEEAHSE
  714-  786 (108.48/54.94)	SEPGAvPQTNYLKRHG.KGL.LKRNARP..NSLDSLMGSLGGIDGLTADVG...VGKYN..NMTAAGDESSS..DSDSDESYAD
  800-  856 (62.90/35.95)	STVNG.PADSDAVSQGTP....VRDAEPlnEADDRLALELPR....LLRPDTPeISLPQY.FADPEP.................
 1355- 1413 (68.62/32.68)	..PNI.VSPEA..........MATPATP..ARDASTLAATPGGD.STADPETE.SVLADVtDQTWGAISSHRLsNS........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.36|      57|     566|     374|     434|       3
---------------------------------------------------------------------------
  374-  434 (85.08/55.00)	KKVLDV......SSTNRVGEMIISVHDESHDPLAlARTWFNASAEreeKLSRRRSDRRTAQAADAQG
  933-  995 (92.28/49.46)	KALLDIqdiplmGQPARVQPRAIPGRDPNSDPVR.PSNLYQIPSP...HLEVRRADNKLSVLPSAIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.97|      62|     340|     859|     924|       7
---------------------------------------------------------------------------
  859-  924 (96.74/67.42)	LDLPLSDEDlilVAQLVTEQAAIG...ALDIyDHR.SEESYDDD........AAC.QRPPYFATRGSIDILQHIVSSFL
 1202- 1276 (89.23/51.42)	IDFKLNNNP...SASLIRENSCIHvayATSV.DKRwISAAWTDDrgneqataSYCfGRKDKSPSRTMNDIANEIWESTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.60|      16|      17|    1421|    1436|       8
---------------------------------------------------------------------------
 1421- 1436 (28.58/21.54)	PAFISGYLVK.RTGSKA
 1440- 1456 (24.03/16.78)	PAIMEVNLVHtEAGSRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.19|      24|     234|     105|     128|       9
---------------------------------------------------------------------------
  105-  128 (39.94/27.98)	LHKSRLQTQQSTQTINSTATPTAS
  340-  363 (42.25/30.09)	INKLRLQEARTEEKRNNEPCPTFS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02129 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EREEKLSRRRSDRRTAQAADAQGQDPRLSRPNAPSPLAMRQQGASGANMVYPTPPDALHNLNGVTPTLDGALSSPGNPLSAANVDIDAAPSASHVINSGEEEAHSEAGDSKRLNSDVNLLNGADNIFEDMGGDMF
2) KYNNMTAAGDESSSDSDSDESYADIGGDPSPLKTGFRSTVNGPADSDAVSQGTPVRDAEPLNEA
3) NDITEADFNFFDEEPSAMEMEPHDEKPLDKDDLDGTPRVEHNTDVTAAPEQSVSIKEEPVVFAKPELRHARSSQVDENQRGKENSFGKTLKRSS
4) QSTQTINSTATPTASASDSQRHGLNSPSQLSVTTPQDHESKASNLSQQE
5) SITSYTTPVSTPQPNIVSPEAMATPATPARDASTLAATPGGDSTADPETESVLADVT
412
763
549
114
1342
546
826
642
162
1398










Molecular Recognition Features






MoRF SequenceStartStop




1) DITEADFNFFDEEPSAM
550
566