Description | Putative RNA polymerase II transcription mediator |
Sequence | MGDSLTQLQDAVDQLAQQFVASLHFVHRRHDLETLGPNDQVRDVKQDQGANEVDALPNDEFRAGLEELSCDLILKEQQIEVLISLLPGLNKSEQDQEQTVKELEEELKVAEAQRQEALKERDRILSQLDSVIRSIRRP |
Length | 138 |
Position | Middle |
Organism | Torrubiella hemipterigena |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Torrubiella. |
Aromaticity | 0.02 |
Grand average of hydropathy | -0.670 |
Instability index | 61.93 |
Isoelectric point | 4.56 |
Molecular weight | 15751.38 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi transcription coactivator activity GO:0003713 IEA:EnsemblFungi transcription corepressor activity GO:0003714 IEA:EnsemblFungi |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP02125 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 35.71| 11| 18| 31| 42| 1 --------------------------------------------------------------------------- 31- 42 (15.56/17.33) DLETLgPNDQVR 52- 62 (20.16/15.15) EVDAL.PNDEFR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 42.79| 14| 15| 89| 102| 2 --------------------------------------------------------------------------- 89- 102 (22.11/13.59) LNKSEQDQEQTVKE 107- 120 (20.68/12.30) LKVAEAQRQEALKE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ANEVDALPNDEFRAGLEELSCDLILKEQQIEVLISLLPGLNKSEQDQEQTVKELEEELKVAEA 2) DQVRDVKQD 3) EALKERDRILSQLDSVIRSIRRP | 50 39 116 | 112 47 138 |
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