<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02090

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAADLGQQTVEFSALVSRAADDSFLSLKELVDKSKSSDQSDSEKKVNILKYVFKTQQRILRLYALAKWCQQVPLIQYCQQLASTLSSHDACFTQAADSLFFMHEGLQQARAPIYDVPSATEILLTGTYERLPKCVEDISIQGTLTDDQQKSALKKLEILVRSKLLEVSLPKEISEVKVTDGTALLRVDGEFKVLVTLGYRGHLSLWRILHLELLVGERRGLVKLEQVHRHALGDDLERRMAAAENPFTTLYSILHELCISLVMDTVLKQVHSLRQGRWRDAIRFDVISDGITGGSTQLNHDGETDLSGLRTPGLKIMYWLDFDKNTGSSDPGSCPFIKIEPGPDMQIKCVHSTFVIDPLTNKEAEFFLDQSCIDVEKLLLRAICCNKYTRLLEIQKELKKNVQICRTADDVVLEHQVDEPDVDPKKKDKIHDPIAFEGEEILRVRAYGSSFFTLGINTRNGRFLLQSSHNKLVTSSLTECEEALNQGSMNAADVFIRLRSRSILHLFASISRFLGLEVYENGFSAVRLPKNISNGSSMLLMGFPDCGNLYFLLMQLDKDFKPQFKLLETKPDPSGKARGLSDLNNVIRVKKIDVDQTQILEDELNLSLLDWGKLFPLLPNSAGNQTPENGLLPDIGIDGALQIAGYPPSSFSSVVDEVFELEKGPPPVPSFSVSNLSQSFNSTASHYGSLSNIHNVKGVPSPKWEVGMQPSQGNNVAKLSNIPSHSNGSLYSASNLKGPVPSTSMGSISSGPGRGAATRRLSNSKSEQDLTSLRYTNPVEGGSYTALDDDHISMPSDTSKDGVYANRSSRLLSPTPHGGPRISGSIKPNGSRSSPTAAPTGSLRPSGSCSSVSTPVSQNQDTCSSPVYESGLKSDCSRKRTASDMLNLIPSLKGIDAYNGLSKRRKVSESARFSKPSSQLLISKEMVSRTEYSYGNLIAEANKGAAPSSTYVSALLHVIRHCSLCIKHARLTSQMDALDIPFVEEVGLRNASTNIWFRLPFARDDSWQHICLRLGRPGTMCWDVKIHDQHFRDLWELQKKSTTAPWGPDVRIANTSDKDSHIRYDPEGVVLSYQSVEADSIDKLVADIRRLSNARMFAIGMRKLLGVGTDEKLEESSTTSDKAPVTKGASDTVDKLSEQMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAGPVSTLPGIVATLSSLPKHGGYTPTQSVLPSSSATNTGQVTNGPVGNAVSTNVSGPLANHSLHGAAMLAATAGRGGPGIAPSSLLPIDVSVVLRGPYWIRIIYRKQFAVDMRCFAGDQVWLQPATPAKVNPSMGGSLPCPQFRPFIMEHVAQELNGLEPNFPGVQQTVGLSAPNNQNPNSSSQIAAANGNRLSLPGSPAMPRAGNQVANINRVGNALSGSSNLASVSSGLPLRRSPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILRDNEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQPNSATAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGVAQAQGGDIAPAQKPRIELCLENHSGLSTDENSERSTSKSNIHYDRQHNSVDFALTVVLDPAHIPHMNAAGGAAWLPYCVSVKLRYSFGESLVVSFLGMEGSHGGRACWLRVDDWEKCKQRVARTVEVSGSSTGDVSQGRLRIVADNVQRTLHMCLQGLREGSEIATITSSTS
Length1820
PositionTail
OrganismCucumis sativus (Cucumber)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Cucurbitales> Cucurbitaceae> Benincaseae> Cucumis.
Aromaticity0.06
Grand average of hydropathy-0.228
Instability index43.03
Isoelectric point7.70
Molecular weight198518.39
Publications
PubMed=19881527
PubMed=19495411
PubMed=20565788
PubMed=22047402

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP02090
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     110.35|      19|      19|     816|     834|       1
---------------------------------------------------------------------------
  793-  810 (26.13/10.85)	SM.....PSDTSK.DGVYANRSSR
  814-  832 (33.23/15.80)	PT.....PHGGPRISGSIKPNGSR
  833-  849 (29.61/13.27)	SS.....PTAAP..TGSLRPSGSC
  850-  873 (21.37/ 7.54)	SSvstpvSQNQDTCSSPVYESGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.29|      33|     163|     378|     410|       2
---------------------------------------------------------------------------
  378-  410 (56.93/42.77)	LLLRAI..CCNKYTRLLEIQKELKKNVQICRTADD
  538-  572 (55.36/41.36)	MLLMGFpdCGNLYFLLMQLDKDFKPQFKLLETKPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.17|      20|      20|    1397|    1416|       4
---------------------------------------------------------------------------
 1383- 1397 (19.79/ 6.91)	....NGLE.PNFPG.VQQTVG
 1398- 1417 (34.33/17.41)	LSAPNNQN.PNSSSQIAAANG
 1420- 1439 (23.06/ 9.27)	LSLPGSPAmPRAGNQVANIN.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.71|      28|      51|    1079|    1108|       7
---------------------------------------------------------------------------
 1079- 1108 (44.39/41.61)	DSIDKLVADIRRlsNARMFAIGMRKL...LGVG
 1131- 1161 (44.32/33.87)	DTVDKLSEQMRR..AFRIEAVGLMSLwfsFGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.09|      23|     357|    1343|    1365|       8
---------------------------------------------------------------------------
 1343- 1365 (43.64/28.44)	AGDQVWLQPATPAKVNPSMGGSL
 1717- 1739 (43.45/28.29)	AGGAAWLPYCVSVKLRYSFGESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.07|      20|     357|    1175|    1199|       9
---------------------------------------------------------------------------
 1175- 1199 (31.22/33.38)	EGCTMHVSPDQlwPHTKFledFING
 1535- 1554 (36.85/21.57)	EGALLNLDPEQ..PALRF...FVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.16|      24|     240|    1225|    1250|      10
---------------------------------------------------------------------------
 1225- 1249 (38.58/32.55)	PARAGPVS..TLPGiVATLSSLPKHGG
 1279- 1304 (36.58/19.22)	TNVSGPLAnhSLHG.AAMLAATAGRGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     168.51|      37|      39|     685|     721|      11
---------------------------------------------------------------------------
  620-  645 (24.89/ 7.70)	............NS.AG.NQT.P...ENGLLPDIGiDGALQIAG
  649-  682 (29.61/10.51)	SS.FSSvVDEVFELeKG.PPPvPSF.SVSNLSQSF.NS......
  685-  721 (66.24/32.31)	SH.YGS.LSNIHNV.KG.VPS.PKW.EVGMQPSQG.NNVAKLSN
  724-  763 (47.78/21.32)	SHsNGS.LYSASNL.KGpVPS.TSMgSISSGPGRG.AATRRLSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.68|      14|     357|     216|     229|      12
---------------------------------------------------------------------------
  216-  229 (25.16/16.96)	GERRGLVKLEQVHR
  575-  588 (24.52/16.32)	GKARGLSDLNNVIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     313.85|      99|    1351|     234|     335|      13
---------------------------------------------------------------------------
  234-  335 (164.51/139.76)	DDLERRMAAAENPFTTLYSILHELCISL.VMDTVLKQV...HSLRQGRWRDAI.....RFDVISDGITGGSTQLNHDGETDLSGLRTPglKIMYWLDFdKNTGSSDPGSCP
 1605- 1712 (149.34/114.70)	DYFSRRVASEPYDASRVASFITLLTLPIsVLREFLKLIawkKGVAQAQGGDIApaqkpRIELCLENHSGLSTDENSERSTSKSNIHYD..RQHNSVDF.ALTVVLDPAHIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.86|      18|      19|    1489|    1507|      16
---------------------------------------------------------------------------
 1489- 1507 (27.65/20.53)	Y.GGGWVpLVALKKVLRGIL
 1509- 1527 (28.21/15.31)	YlGVLWL.FAQLPDLLKEIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02090 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NGSLYSASNLKGPVPSTSMGSISSGPGRGAATRRLSNSKSEQDLTSLRYTNPVEGGSYTALDDDHISMPSDTSKDGVYANRSSRLLSPTPHGGPRISGSIKPNGSRSSPTAAPTGSLRPSGSCSSVSTPVSQNQDTCSS
727
865










Molecular Recognition Features






MoRF SequenceStartStop




NANANA