<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02038

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceDDAMRKAGVAHNKSSKDMESHVFMKAKTREEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGGPPAGAPGMGMASRAQGAPMSGMSGLGPMGQQMTLPGQQQPPGTSGMAPHGMPGVSTATQQTQLQLQQIAQQQQQQQQFQQQQVALQQQQFQAQQSAMQQQFQVQQQQAAAAAAAQQQQQQQQLQAVQQQQQHMLKLQMQQQQNQQQMQQQQQQQQLQRIAQMQQLQAAQAMQAQQQQQQQQQQQQMPQQQIQQQPPQQVMQQQMQQMQQQQQQQQQQQQVAQAQQSQLPPQSQPQPQPMVSQPQAISGQIPKVSCPNQVHMFTLFFVFVLEVRAQLVQQQQAAAAVQAAQAQAAQMGASGQVPILCSLLLLLIICFSTFQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGPPITAPVASPRKRKYEEDERQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIKNPRQYAANPFLQSVYRYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length754
PositionTail
OrganismCharadrius vociferus (Killdeer) (Aegialitis vocifera)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Charadriiformes> Charadriidae> Charadrius.
Aromaticity0.04
Grand average of hydropathy-0.709
Instability index84.22
Isoelectric point9.55
Molecular weight83526.10
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02038
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     223.83|      32|      32|     183|     214|       1
---------------------------------------------------------------------------
  183-  214 (67.14/16.28)	QQQQQQQQLQAVQQQ.QQHMLKLQ....MQQQQNQQQ
  216-  247 (50.82/ 9.97)	QQQQQQQQLQRIAQM.QQ....LQaaqaMQAQQQQQQ
  248-  278 (52.71/10.70)	QQQQQQMPQQQIQQQpPQQVMQQQ....MQQM..QQQ
  279-  306 (53.16/10.88)	QQQQQQQQ.Q.VAQA.QQSQLPPQ....SQPQP..QP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     131.88|      21|      21|     402|     422|       2
---------------------------------------------------------------------------
  402-  422 (45.94/17.10)	PVQQAQTPQSMPP...PPQPQPSP
  424-  443 (28.10/ 6.89)	PGQ....PTSQPNsnvSSGPAPSP
  457-  472 (26.87/ 6.19)	SPAAARTPQNF........SVPSP
  610-  627 (30.97/ 8.54)	PAMTAIHG...PP...ITAPVASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.21|      21|      21|     127|     147|       4
---------------------------------------------------------------------------
  127-  147 (40.38/14.05)	QQTQLQLQQI.AQQQQQQQQFQ
  149-  170 (35.84/11.46)	QQVALQQQQFqAQQSAMQQQFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.93|      28|      35|      58|      91|       5
---------------------------------------------------------------------------
   58-   91 (45.03/28.14)	PMNALQNLTG.GPPAGAPGMGmasrAQGapMSGMS
   95-  123 (53.90/21.26)	PMGQQMTLPGqQQPPGTSGMA....PHG..MPGVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.53|      14|      23|     648|     661|       7
---------------------------------------------------------------------------
  648-  661 (24.62/12.55)	VARLNPKFLVNLDP
  673-  686 (26.92/14.31)	ICKLDDKNLPNVPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.82|      28|     125|     564|     591|       8
---------------------------------------------------------------------------
  564-  591 (53.57/23.66)	DMAVPTPPPPPVPP...TKQQYLCQPLLDAV
  688-  718 (44.25/18.18)	QLSVPADYPDQSPLwikNPRQYAANPFLQSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.40|      22|      34|     493|     515|       9
---------------------------------------------------------------------------
  493-  515 (33.57/24.05)	SEEQQYLEKLKQL.......SKYIePLRRM
  523-  551 (30.84/17.26)	EDRKKDLSKMKSLldiltdpSKRC.PLKTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02038 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IHNKKSQASVSDPMNALQNLTGGPPAGAPGMGMASRAQGAPMSGMSGLGPMGQQMTLPGQQQPPGTSGMAPHGMPGVSTATQQTQ
2) ITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQ
46
394
130
504










Molecular Recognition Features






MoRF SequenceStartStop




NANANA