<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02026

Description Mediator of RNA polymerase II transcription subunit 12-like (Fragment)
SequenceQDELTAVNVKQGFSNQPAFSGDEHGSARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGSKPLTLLAKKVPILSKKEDVFAYLAKYSVPLLRAAWLIKMTCAYYAAISEAKIKKRQATDPNIEWTQIITRYLREQLAKVAEFYHVTSSQGNSSVVMPQEMEQALKQWEYNEKLSFYMFQEGMLERHEYLTWILDVLEKIRPTDDDLLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDGPNLVAAHSPHMIIGPSNPPLAAASPTAPGPVVSPVQLACSDFLSCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKNVNPGSPLDLLQIAPSSLPMPGGNSAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESLSSASLTGSSLPVFQNVLLRFLDTQAPSLSDPNSDHEKTEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSITATTRPRSPNGEAVDEHYSKDHDVKLEDHSIMEHMGIDSGTASIFDDVDKSDFKTDFGSEFPVDRRISITSEKSVKRERLRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMILLYGVGKERDEARHQLKKITKDILKILNKKSTTEMGVGDEGQKVRKTKQEAFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNSEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAGRINDIANLCAELTACCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGTGKLFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSNNVDSSKSEDFHMRGLLDELNEDEIWGSSHTLKSCGKAVSIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGVKECTEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQVKQAHNHEHPSLDVLCVISFMCIRWQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGPEENKRAYMNLVKKLKKELGDKRSDSIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHTHTKPKPRSYYLEPLPLPPEEEEEEPTTPVSQEPERKPGELSDQGKLATDDEKKTKGRKRKSKSSSRPDVSS
Length1783
PositionKinase
OrganismCharadrius vociferus (Killdeer) (Aegialitis vocifera)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Charadriiformes> Charadriidae> Charadrius.
Aromaticity0.07
Grand average of hydropathy-0.301
Instability index49.30
Isoelectric point6.22
Molecular weight199501.30
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02026
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     574.49|     147|     148|     519|     666|       1
---------------------------------------------------------------------------
  418-  524 (163.82/108.12)	STAGVTISR..VLHT..LEVLD..RHCFDRSD.SSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSC...KRSGK.HRA................................MAV....AK.LLEK.RQAEIEAERCGESEV.....LDEKESL
  525-  672 (235.18/163.19)	SSASLTGSSLPVFQNvLLRFLD..TQAPSLSDPNSDHEKTEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSI...TATTR.PRSPNGEAV....DEHYSKDHDV..KLEDHSIMEHMGIDSGTAS.IFDDVDKSDFKTDFGSEFPVDRRISITSEKSV
  673-  819 (175.50/116.44)	KRERLRELIFPSNYD.LLRHLQyaTHFPIPLDESSSHECNQ..RMILLYGVGKERDEARHQ...LKKITKDILKIlnkKSTTEmGVGDEGQKVrktkQEAFPTLETVftKLQQLSYFDQHQVTSQISSnVLEQI..TSFASGTSYHLPLAHHIQL......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.54|      13|      36|    1674|    1686|       2
---------------------------------------------------------------------------
 1674- 1686 (26.36/15.92)	LFEGHKNPAPLSW
 1709- 1721 (26.18/15.76)	LYHTHTKPKPRSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.53|      25|      36|    1186|    1213|       3
---------------------------------------------------------------------------
 1186- 1213 (32.01/40.73)	SKSEdFhMRGLLDELNEDEiWGSSHTLK
 1225- 1249 (47.51/37.00)	SLSE.Y.ARYVLRTICQQE.WVGEHCLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.91|      28|     147|     880|     909|       4
---------------------------------------------------------------------------
  880-  907 (49.20/28.30)	CLILNSEQTAQVFEGLCGVVKHV..VNPSE
  926-  948 (32.03/14.18)	CSHLRS.KFGDLFSSACSKVKQT..I....
 1029- 1057 (40.69/21.28)	CTVLSSEWLG.VVKALCCSSNHVwgFNDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.85|      20|      38|    1607|    1627|       5
---------------------------------------------------------------------------
 1607- 1627 (31.99/28.88)	GDKRS..DSIDKvRQLLPLPKQT
 1644- 1665 (29.86/20.91)	GNKIAgfDSIDK.KQARGLQVST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.44|      31|      39|    1275|    1310|       7
---------------------------------------------------------------------------
 1275- 1310 (49.07/40.89)	LQLIcyphgVKEC.TEGDNPQRQHIKRILQNLDQWTL
 1317- 1348 (47.36/26.19)	LQLM.....IKQCmKEPGSGSVAEMNSLLDNIAKATI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02026 with Med12 domain of Kingdom Metazoa
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