<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02024
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MAGVPAVRISIESACEKQVQEVGLDGSEPSLQPLSMSQNLARLAQRIDFSQGSGSEEDEPGSAGRSWAEPGEAEDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVKDKKFMTLDPVVQDPLPPKQNPQFLQLISKKKSLAGAAQILLKGAERLSKSVAENQENKRQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFLHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPMPKSKPGSPHWQTKLETAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPGLQLSISLCHSSNDKKSQKSASEKQNPEDHLYVLEHNLHQLIRECHKQTLSSTVMPHPASAPFGHKRMRLAGPQAFDKNDISSLQSNEGLLEKIIKQAKHIFLRRRTARTIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWHVLSFSNHVGLGPVESIGNASAITVASPNGDYAISVRNGPESGSKVMVQFPRSQCKDLPKGDVLQDSKWNHLRGPFKEVQWNKMEGRNFVYKMELLMAALTPC |
Length | 643 |
Position | Head |
Organism | Charadrius vociferus (Killdeer) (Aegialitis vocifera) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda>
Coelurosauria> Aves> Neognathae> Charadriiformes> Charadriidae> Charadrius.
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Aromaticity | 0.06 |
Grand average of hydropathy | -0.461 |
Instability index | 56.02 |
Isoelectric point | 8.39 |
Molecular weight | 72040.41 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
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GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
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Interaction
Repeat regions
Repeats |
>MDP02024
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 577.14| 197| 221| 92| 311| 1
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93- 310 (286.42/247.83) RnnLRSALTEMCVLYDVLS..IVKDKKFMTL.....DPVVQDPLPPKQNPQfLQLISKKKSLagaAQILLK.GAERLSKSVAENQENKrqrDFNSELLRLRQHWKLRKVGDKIL....GDLS..YRSAGSLFLHHGTFEVIKN..TDIDlDKKIPEDYCPLD......VQIPSDLEGSAYIKVSIQKQApDIG..DLGTVNLFKRPMPKSkpgspHWQTKLetaQNVLLCKeiFAQLSREAV
311- 531 (290.71/192.32) Q..IKSQIPHIVVKNQIISqpFPGLQLSISLchssnDKKSQKSASEKQNPE.DHLYVLEHNL...HQLIREcHKQTLSSTVMPHPASA...PFGHKRMRLAGPQAFDKNDISSLqsneGLLEkiIKQAKHIFLRRRTARTIDSlaSRIE.DPQIQAHWSNINdvyessVKVLITSQGYEQICKSIQLQL.NIGveQIRVVHRDGRVITLS.....HQEQEL...QDFLLSQ..MSQHQVHAV
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