<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02021

Description Mediator of RNA polymerase II transcription subunit 16 (Fragment)
SequenceAMDLAYVCEWEKKPKSNHCPSIPLVCAWSCRNLIAFTTDLKNEEEKDLTHMVHIIDTEHPWDVYSVNSGHTEVITCLEWDQSGSRLLSADADGHIKCWSMTDHLANSWENTVGSMVEGDPVVALSWLHNGVKLALHVEKSGASNFGEKFSRVKFSPSLTLFGGKPMEGWIAVTISGLVTVSLLKPNGQVLTSTESLCRLRCRVALADVAFTGGGNIVVATSDGSSTSPVQFYKVCVSVVNEKCKIDTEILPSLFMRCTTDPARKDKYPAITHLKFLARDMSEQVLLCASNQNSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLGLALAFHDGSVHIVHRLSLQMMAVFYGSSSQRSVDEQAIKRQRTAGPLVHFKAMQLSWTSLALAGIDSHGKLSMLRISPSMGHVLDMNMSLRHLLFLLEYCMVTGYDWWDILLHVQPNMVQNLVEKLHEEYMRQNAALQQVLSTRIVAMKASLCKLSSSTIARVCDYHAKLFLIAISCTLKSLLRPHFLNTPDKSPGDRLTEICSKITDIDIDKVMINLKTEEFVLEMTTLQSLQQLIQWVGDFVLYLLASLPNQGSPVRPGHSFLRDGASLGMFRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWLCCREENHITEPDDTLIDECCLLPSQLLIPNIDWLPINDGIISKLQNKQLVRLQFGKAPGLIGHTVSSQFDAFVRAPGQPKIDHLRRLHLGAYPTEECKSCTRCGCVTMLKSPNKVTAVKQWEQRWIKNCLCGGLWRRMPLSYS
Length831
PositionTail
OrganismCharadrius vociferus (Killdeer) (Aegialitis vocifera)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Charadriiformes> Charadriidae> Charadrius.
Aromaticity0.07
Grand average of hydropathy0.002
Instability index46.03
Isoelectric point8.04
Molecular weight92907.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02021
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.61|      21|      97|     317|     339|       1
---------------------------------------------------------------------------
  317-  337 (37.73/22.14)	PVVGDKQPMILKWRILSATND
  343-  363 (33.89/13.84)	AVALPKLPISLTNTDLKVAND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     412.57|     122|     135|     454|     588|       2
---------------------------------------------------------------------------
  406-  453 (56.22/24.50)	...................................................EQAIK....RQRTAGPLVHFKAMQLSWTSLALAGI.DSHGKLSMLRISPS.............................................MGH
  454-  588 (177.09/133.99)	VLDMNmSLRHLLFLLEYcmvTGyDWWDILLHVQPNmvQ.NLVEKLHeEYMRQNAAL....QQVLSTRIVAMKASLCKLSSSTIARVCDYHAKLFLIAISCTLKSLL.....RPHfLNTPDkspgDRLTEIC....SKITDIDIDKVMIN
  595-  725 (179.26/99.25)	VLEMT.TLQSLQQLIQW...VG.DFVLYLLASLPN..QgSPVRPGH.SFLRDGASLgmfrELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRL.....LTKLWlccreENH.ITEPD....DTLIDECcllpSQLLIPNIDWLPIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.98|      14|      17|     736|     751|       4
---------------------------------------------------------------------------
  736-  751 (22.14/23.00)	QLVrlQFGKAPGL..IGH
  756-  771 (22.85/15.39)	QFD..AFVRAPGQpkIDH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02021 with Med16 domain of Kingdom Metazoa
Unable to open file!