Description | Mediator of RNA polymerase II transcription subunit 1 (Fragment) |
Sequence | SGIPLFDTTPTFVPLYELITQFELSKEADPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGVNKQKKKKSRVPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPTANEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTSNSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYAPQALSTLGVQVLGSDGGENKFKGSSQSDTVDFSIIAAASKALGSSDIMEHHTGGQSPLLNTGDLAKEKSQKRVKEGNGSGSSMAGPGLDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGGSSSGQSKSSAQSVGKPGSSPITKHGLSSGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGAGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGPNSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDSLRPQMASSKSYGSPLISGSTPKHERCSPSHGKSPAYTPQNVDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSIKPESWSKSPISADQSLSMTSSAIISAERPSRASPEFLIGEEDDDLMDVALIGN |
Length | 1257 |
Position | Middle |
Organism | Tinamus guttatus (White-throated tinamou) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Palaeognathae> Tinamiformes> Tinamidae> Tinamus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.750 |
Instability index | 55.81 |
Isoelectric point | 8.92 |
Molecular weight | 132053.69 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP02000 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 1129.55| 162| 162| 663| 824| 1 --------------------------------------------------------------------------- 217- 340 (74.03/11.35) ......................................................................................PPAS..SPGygmttGSNPmsGTTTPTN.TFPGgpittlfnmsismkerhdsvghgedfskVSQNPILTSLLQI.TGNV..............GStIGSSPTPPHHTPPPVSSPA.....SNTKN.HPMLMNLLKENPPQ.DF..................STLY...........GSS 341- 476 (157.73/32.86) PLERQ.NS.......SS......GSP.....RM....EMGPGVNKQ...........KKKKSRVPAD.KPKHQT.EDdfqRElF.SMDVD..........SQNP...IFDVNM.TADT............................LDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRM.VRLSSSDSIGADVTDILSD.....IAEEA.SKLPTANEDCP.......................................... 477- 629 (143.86/29.29) .........................PiGTPVRD....SSSSGHSQSAL...............FDPD.VFQTSN.SE...NP.Y.TDPADliADA.....AVSP..NSDSSNHfFPDG............................VDFNP..........DLLNSQSQSGFGEEYFDES.SQSGDTDDFKGYAPQALSTlgvqvLGSDG.GE...NKFKGSSQS.DTvdfsiiaaaS........KALGS.SdimehhTGGQS 652- 813 (276.66/63.41) SGSSM.AGPG.....LD......GKP.GKRSRT....PSSDGKSKEKL........PKRKKQETDGK.SPSHSS.SN...RP.F.TPPAS..TGG.....SKSP..GSSGRSQ.TPPG............................VATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGS.VTSSSSKSHHSHSSSSSSS.....SSSTS.GKIKSSKSEGSSGS.KM.........S........SSLYS.S......QGGSS 814- 949 (177.87/38.03) SGQSK.SSAQ.....SV......GKP.GSSPITkhglSSGSGSTKMK.........PQGK..PSSLM.NPSMS.......KP.N.ISPSH..........SRPS..GGSDK...................................LASPMKP.....VP.GT....PPSSKAK....SP.I...SSGSGGSHMSGAGSS.....SS......MKSSSGMGSSGS..M.........SqkpppssnSSTAS.S......SSFSS 950- 1093 (145.95/29.83) SGSSM.SSSQnqhgsSK......GKS.PSRNKK....PSLTA.VIDKLkhgvvtsgPG.GEDPMDGQmGPNSNS.SS...H...........TMS.....SKHN..MSGGEFQ.....................................................GKREKSDKEKSKVS.VSGGSVDS..SKKTSDSKN.....VGSTGvAKIIISKHDGGSPSiKA.........K........VTLQKpG......EGGGD 1094- 1231 (153.47/31.76) SLRPQmASSK.....SYgsplisGST.PKHERC....SPSHGKS............PAYTPQNVDSE.SESGSSiAE...KS.YqNSPSS.........................DDG............................I..RPLPEYSSEKHKKHKKEKKKVKDKDRDRDRD.RDKDRDK.KKSHSIKPESW.....S........KSPISADQSLS.MT.........S........SAIIS.A......E.... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 78.19| 25| 53| 30| 57| 2 --------------------------------------------------------------------------- 30- 57 (41.81/40.65) PLPLN...HNMRfYAALPGQqhCY...FLNKDAP 81- 111 (36.38/22.94) PLILNlirHQVA.YNTLIGS..CVkrtVLKEDSP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYF 2) IPKITIQIPKGT 3) IRPLPEYSSEKHKKHKKEKKKVKD 4) KKPSLTAVIDKLKHGV 5) RDRDR 6) SIKAKVTLQ 7) SPEFLIGEEDDDLMDVALIGN 8) VAKIIISK 9) YGSPLI | 552 733 1160 973 1186 1077 1237 1063 1105 | 557 744 1183 988 1190 1085 1257 1070 1110 |
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