<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01994

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceAELTGIKWRRYNFEGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVDVIHHELHMVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFIRPYDKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPSPFQVLVSPYGLNGTLTGQSYKMSDPATRKLMEEWQYFYPMVLKKKEGMKEEEELGYDNDFPVAVEVIVGGVRMVYPSAFVLISQSDIPVSQSAANTGSHINVGQQGLGSVKDPASTCGMPLTPPTSPEQAIMGESGGSQSTISHSAVQERTVSVHSPKKSGKITPKFHNHMVHRVWKECILNRSQSKRSQVTTANLEEEVPSNAVSWDFVDPVQRVSCSCSRHKVFKQRCAPGSSRPPTVTPPGFSVGTSSSSSLPPPASSKHKTTERQDKGDKLQKRPLMPFHHRPSVTEELCMEQDTSGQKLGLAGIEQSLEVPSSRKYEKPLSIPARNPSKQINMNPMDSPHSPTSPLPPTLSPQPRGQEAENLDPPSVPVNPALYSSGLELQPLPSLDDRTILVGQRLPLMAEVSETALYCGIIHNSDSLDMWRTYSVPPTDDPEFRPPDLPCERYDAKMEVNSDSTALKRLLAQPNKRFKILEDNKPAQMLNYPHPFPLTHQPGEGLGDASDPYTFEDGDIKYSFTGNKKCKLGAEKDLLKKNKSEDGIGTKDIPTAGHSAPVPDGKDAMSIFSSAPKTDTRQDNAAGRVGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKTPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVNMVPTQLAEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSIFAPLKILPSQCLLPLKIPDACIFRPSWAVPPKIEQLPLPPAATFIRDGYNNVPSVGSLADQDYLQMSTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQPIPEAHSLYVTLILSDSVLNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFIEDELDIFGKTSDIGQAAERRLMMCQSNLLPQMGEGARRTQEPPMSLLLLLQNQHTQPFTSLSCLDYMSSNNRQPLPCMNWSYDRLQADSNDSWVECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLDGAKTFFRDLSAMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFSQPWGTEECDNHSRLKLYAQVCRHHLAPYLATLQLDSSLFLPPKYQMPAPASQAQTVPGNSGSVPSNPACLSAPGAPPAGSAFNPAPNGGTSSLPAAAVSSSGSSLPQLSASSAAPGISQMTTTSTPGFSGNMCPGQSTSTAGNTADRSQGSAGPGGDVDSGQNVPPQQQEGQEGVTERERIGVPTEPESADSNAYPPAVVIYMVDPFTYTADEESASANFWLLSLMRCYTEMLENLPENMRNSFILQIVPCQYMLQTMKDEQVFYIQHLKSLAFSVYCQCRRPLSTQIHIKSLTGFGPAASIEMTLKNPERPCPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIDLPNRSRRSKLSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKEVCRMCGISSADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPTNDDMFDLPFPDDIENDFGILITGNLHSPPNSSPVPSPGSPSGIGVGSHYQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNIL
Length2190
PositionMiddle
OrganismTinamus guttatus (White-throated tinamou)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Palaeognathae> Tinamiformes> Tinamidae> Tinamus.
Aromaticity0.07
Grand average of hydropathy-0.374
Instability index61.40
Isoelectric point5.65
Molecular weight240533.88
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01994
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     458.96|     112|     114|     326|     439|       1
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  257-  324 (46.07/17.24)	...............................................................PSAFVLISQSDiPVSQ.SAANTGSH..iNVGQQGLGsvkdPASTcgmplTPPT.SP.EQAIMGESGGSQSTIS
  326-  439 (192.29/108.22)	SAVQERTVSVHSPKKSGK..ITPKFHNhmVHR..VWKEC.ILNRSQSKRSQVTTANLEE..EVPSNAVSWDFVD.PVQR.VSCSCSRH...KVFKQRCA....PGSS.....RPPTVTP.PGFSVGTSSSSSLPPP
  441-  551 (147.27/76.51)	SSKHKTTERQDKGDKLQKrpLMP.FH....HRpsVTEEL.CMEQDTSGQ.KLGLAGIEQslEVPS...SRKYEK.PLSI.PARNPSKQinmNPMDSPHS....PTSP.....LPPTLSPqP...RG.QEAENLDPP
  570-  631 (73.33/33.54)	PSLDDRTILV......GQ..RLPLMAE..VSE..TALYCgIIHNSDSLDMWRTYS.......VPPT....D..D.PEFRpPDLPCERY................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     295.16|      69|     115|     839|     907|       2
---------------------------------------------------------------------------
  731-  800 (81.62/45.69)	.PT....AGHSA..PVPDG.KDAMSifssapktdT.RQDNAAG.....RVGSGSLTQV.TDLAPSLHDLDNIFDN.SDEDELGAVS
  839-  907 (122.51/73.14)	FPTPPSLEQHPAFSPVMNY.KDGIS.........S.ETVTALG.....MMESPMVNMVPTQLAEFKMEVEDGLGS.PKPEEIKDFS
  950- 1023 (91.03/52.00)	WAVPPKIEQLP.LPPAATFiRDGYN.........NvPSVGSLAdqdylQMSTPQMN.TPVTLNSAAPASNSGAGVlPSPATPR.FS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     564.63|     180|     434|    1438|    1638|       3
---------------------------------------------------------------------------
 1438- 1638 (269.21/138.10)	IMRVGKTVAQKLTDelvseWfSQPWGteECDNHSRLKLYAQVCRH.HLAPYLATLQLDSSLF.LPPKYQ...MPaPASQAQTVPGNSGSVPSNPACLSAPGAPPAGSAFnPAPNGGTSSL.PAAAVSSSGSSlPQLSASSAAPGISQMTTTSTPGFSGNM.CPGQStSTAGntadrSQGSagPGGdVDSGQNVPPQQQEGqEGVTERE
 1879- 2065 (295.41/112.64)	IGRLGRLGHGELKD.....W.SILLG..ECSLQTISKQLKEVCRMcGISSADSPSILSACLVaMEPQGSfvvMP.DAVTMGSVFGRSTALNLQSSQLNTPQDASCTHIL.VFPTSATIQVaPANYPNEDGFS.PTNDDMFDLPFPDDIENDFGILITGNLhSPPNS.SPVP.....SPGS..PSG.IGVGSHYQHSRSQG.ERLLSRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.79|      10|     911|     156|     165|       5
---------------------------------------------------------------------------
  156-  165 (19.56/10.27)	SVEIAQHQPI
 1070- 1079 (19.23/ 9.97)	SVEPATVQPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.47|      25|     712|    1354|    1381|       8
---------------------------------------------------------------------------
 1354- 1381 (44.87/31.43)	PEPLPIPTLLVGYdkdFL.TISPFSLPFW
 2067- 2092 (43.60/22.78)	PEELKQQPLALGY...FVsTAKAENLPQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.03|      17|     911|     213|     250|       9
---------------------------------------------------------------------------
  215-  231 (33.45/51.29)	WQYFYPMVLKKKEGMKE
 1336- 1352 (33.58/ 6.07)	WQQFHKMAGRGTYGSEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.78|      16|     714|     707|     724|      11
---------------------------------------------------------------------------
  707-  724 (23.80/19.04)	CKLGAEKDLLKKNKseDG
 1422- 1437 (31.98/19.15)	CRLGQHKPICKVLR..DG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.54|      14|      16|    1200|    1213|      13
---------------------------------------------------------------------------
 1200- 1213 (24.17/13.84)	MSLLLLLQNQHTQP
 1217- 1230 (25.37/14.90)	LSCLDYMSSNNRQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     183.56|      47|    1113|     659|     706|      14
---------------------------------------------------------------------------
  659-  706 (86.11/47.04)	EDNKPAQMLNYPHP.FPL.......THQPGEGLGDASDPYT..FeDGDIKYSFTGNKK
 1025- 1050 (28.20/ 8.87)	...........PTPrTPR.......TPRTPRGGGTASG.......QGSVKY.......
 1767- 1818 (69.25/33.37)	NPERPCPIQLYSPP.FILapikdkqT.ELGETFGEASQKYNvlF....VGYCLSHDQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.46|      28|      37|       8|      38|      16
---------------------------------------------------------------------------
    8-   38 (48.42/41.24)	WRRynfEGHGDCGPIISAPAQDDPILLSFIR
   48-   75 (58.03/39.18)	WRR...DVKPDCKELWIFWWGDEPNLVDVIH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01994 with Med13 domain of Kingdom Metazoa
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