<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01981

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASIAFRIYEPSTDQSHSFQSSALEIQSTFRDQGKLVSYDADRGGIWIFQITNKDGASKAVSFGSGVSLEACGYTLGMVDEGTLEPAALQKNRIPGNTTQNAPTNTAATTSPAEPHQRNPLISPIQTAGVQAEGAQLPAQPVDTRTTQPVPNIIYEQFIIAVISSITLAFCSQSMAVPLNYRTVLIPPLQADTNEQERDSLPTDPVIGTFKTYLTTTGSLVVSLYFSYCQNLATIEDVLSGDSLSPSGSILAAPYGVFATKSGFSNGDIDRNLAQTPNTQALSVRSVSDAHDSLWKHSCLQALEYCGLNPADFKAGSWVNLLITKPTSQDVDGEQKRLRATVPWPGALCFRKKSLEVSTTHRVGDTILSGHEECHDPLGDARGWFASASEREERVSKRKAERAHAAPKEVNGANLQAQSLSGQSPLSVRRPSTATAGVMYPTPPDAIQQHLVVTPSIDGATSSPNNPLPNLAVADADITMPTVTPMADVDNDVWDGGHEQKRARSDSNLLGDTGDIMNDMGGDVFGDHDVTEDDFNFFDGPDGNDMDIDMPDLQPISHQIPHPPPPQAILPQAMPPQAMPPPMIMQPLPQRVIEPRPEIKLKPRPRPKPKIHEPVFAKPELKHARSSLNDELNHKVKTERSNSNKRGSSPFDPDTVFKRVKASLASPTQENFTFQAPVRRKSSIFEKVEFDPKIPLINKKYEHGGTFDFSKDLGSGELKRDIEGLSRDEYLERQGKLNPDSKTFPGVSLIRSLTGADGSANHANAQKSNCNASFSEDSDVDSEADDLSSLSGGPVSPIKSSVKRTVVDDDALSQATTSREAELMDDATEEQLAIELPKLSKTESYEMPLHRFFSDPEPLNAEVGLSNNEFVEVAQIVTEQAATGRLDIGIDHKNGSSVALATMKGHELNVARSSLQLLHNVIPSNLGSATAVRLKGLLEILDLPLAGQPTRLQPRPIPGRDTNVEQLRANNLYQIPVPHLEVRRSETKLSVLPSSVSFWEGLGLSPSWGPKDITALCIFPGWKGMSDHVGSFIDRLKSVYESLKLGTFNNLPLSGDWDDGVLPFEVDRISTSPNATVTGHGSSLVESMEVLRSSLLELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFSEYSKLLADRRESPQNELVLQLVSSNLISSTTSLVVPTPAEMIKLCVETYDRCTLFLGAEYGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLIHENSCIHVGYAESLDGRWITAAWTDNRGQRQATASYSITRSRTPDRSTSHHKAAIIAEIWATTLTMISIWKVHWRVIITRSGPMDQKEVEWWQAASTLDDKYSFTMVLMSVDTSPSLQLVPPVVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMREASTLAATPGADSATEPDADSFLIDATDQTWGAISGHRFGNSTTLLEMRPALASGYLIKRTGIKIEDPPVMMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVTDRETDVRPWHIAVAEKGVRALHLLL
Length1533
PositionKinase
OrganismGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.06
Grand average of hydropathy-0.359
Instability index46.61
Isoelectric point5.28
Molecular weight167278.26
Publications
PubMed=17823352
PubMed=20237561
PubMed=26198851

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01981
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.79|      21|      23|     441|     462|       1
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  441-  462 (34.80/20.21)	LSVrRPST..ATAGVMYPTPPDAI
  466-  488 (31.99/13.93)	LVV.TPSIdgATSSPNNPLPNLAV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     628.22|     240|     867|      78|     435|       2
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  130-  435 (353.50/405.41)	PHQRNP.LISPiQTAGVQAEGAQLPAQPVDTRTTQPVPNIIYE.......QFIIAVISSITLAFCSQSMAVPLNYRtvlIPPLQADTNeqERDSLPTDP...................................................................................................................................................................................................................................................................................................................................................................................................................................................vigtfktyltttgslvvsLYFSYcqnlatiedvlSGDslSPSgSILAAPYGVFATKSGFSNGDIDRNlaQTP.NTQALSVRSVS..DAHDSLWKHS.......CLQALEYCGL.NPADFKAgswvnllitkPT.SQDVDGEQkrlratvPWPGALCFR.....KKSL..EVSTTHrVgdtilsGHEECHDP......LGDARGWF.ASASEREERvsKRKAERAHAAPKEVNGANLQAQSL
  576-  668 (79.48/10.10)	PHPPPPqAILP.QAMPPQAMPPPMIMQPLPQRVIEPRPEIKLKprprpkpKIHEPVFAKPELKHARSSLNDELNHK...VKTERSNSN..KRGSSPFDP....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1122- 1302 (195.24/96.98)	...................................................................................................dtvfkrvkaslasptqenftfqapvrrkssifekvefdpkiplinkkyehggtfdfskdlgsgelkrdieglsrdeylerqgklnpdsktfpgvslirsltgadgsanhanaqksncnasfsedsdvdseaddlsslsggpvspikssvkrtvvdddalsqattsreaelmddateeqlaielpklsktesyemplhrffsdpeplnaevglsnnefvevaqivteqaatgrldigidhkngssvalatmkghelnvarsslqllhnvipsnlgsatavrlkglleildlplagqptrlqprpipgrdtnveqlrannlyqipvphlevrrsetklsvlpssvsfweglglspswgpkditalcifpgwkgmsdhvgsfidrlksvyeslklgtfnnlplsgdwddgvlpfevdristspnatvtghgsslvesmevlrssllelkskdknlvIYFVY...........SPD..NPA.SIIEACTAFYRCFSEYSKLLADRR..ESPqNELVLQLVSSNliSSTTSLVVPTpaemiklCVETYDRCTLfLGAEYGG..........PTpAPAVMLEQ.......PPPRMIDFKlttspSQSLihENSCIH.V......GYAESLDGrwitaaWTDNRGQRqATASYSITR..SRTPDRSTSHHKAAIIAEIWATTL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.25|      10|      28|     501|     511|       5
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  501-  511 (16.40/14.65)	MADVDNDVWdG
  532-  541 (20.85/12.75)	MNDMGGDVF.G
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.71|      37|     878|      78|     115|       6
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   78-  115 (60.67/41.29)	FGSGVSLEACGyTLGMVDEG.TLEPAALQKNRIPGNTTQ
  941-  978 (60.03/35.74)	LGSATAVRLKG.LLEILDLPlAGQPTRLQPRPIPGRDTN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01981 with Med13 domain of Kingdom Fungi
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