Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKANNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLMTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN |
Length | 1548 |
Position | Middle |
Organism | Papio anubis (Olive baboon) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Papio. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.696 |
Instability index | 55.35 |
Isoelectric point | 8.79 |
Molecular weight | 164964.04 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl nucleolus GO:0005730 IEA:Ensembl nucleoplasm GO:0005654 IEA:Ensembl |
GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl estrogen receptor binding GO:0030331 IEA:Ensembl LBD domain binding GO:0050693 IEA:Ensembl nuclear receptor coactivator activity GO:0030374 IEA:Ensembl peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl promoter-specific chromatin binding GO:1990841 IEA:Ensembl protein-containing complex binding GO:0044877 IEA:Ensembl retinoic acid receptor binding GO:0042974 IEA:Ensembl thyroid hormone receptor binding GO:0046966 IEA:Ensembl transcription corepressor activity GO:0003714 IEA:Ensembl vitamin D receptor binding GO:0042809 IEA:Ensembl |
GO - Biological Process | androgen biosynthetic process GO:0006702 IEA:Ensembl angiogenesis GO:0001525 IEA:Ensembl animal organ regeneration GO:0031100 IEA:Ensembl brain development GO:0007420 IEA:Ensembl cell morphogenesis GO:0000902 IEA:Ensembl cellular response to epidermal growth factor stimulus GO:0071364 IEA:Ensembl cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl cellular response to thyroid hormone stimulus GO:0097067 IEA:Ensembl embryonic heart tube development GO:0035050 IEA:Ensembl embryonic hemopoiesis GO:0035162 IEA:Ensembl embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl embryonic placenta development GO:0001892 IEA:Ensembl enucleate erythrocyte development GO:0048822 IEA:Ensembl epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA:Ensembl fat cell differentiation GO:0045444 IEA:Ensembl intracellular steroid hormone receptor signaling pathway GO:0030518 IEA:Ensembl keratinocyte differentiation GO:0030216 IEA:Ensembl lactation GO:0007595 IEA:Ensembl lens development in camera-type eye GO:0002088 IEA:Ensembl liver development GO:0001889 IEA:Ensembl mammary gland branching involved in pregnancy GO:0060745 IEA:Ensembl mammary gland branching involved in thelarche GO:0060744 IEA:Ensembl megakaryocyte development GO:0035855 IEA:Ensembl monocyte differentiation GO:0030224 IEA:Ensembl mRNA transcription by RNA polymerase II GO:0042789 IEA:Ensembl negative regulation of apoptotic process GO:0043066 IEA:Ensembl negative regulation of keratinocyte proliferation GO:0010839 IEA:Ensembl negative regulation of neuron differentiation GO:0045665 IEA:Ensembl negative regulation of transcription by RNA polymerase II GO:0000122 IEA:Ensembl peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl positive regulation of gene expression GO:0010628 IEA:Ensembl positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl positive regulation of keratinocyte differentiation GO:0045618 IEA:Ensembl positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl protein import into nucleus GO:0006606 IEA:Ensembl regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl retinal pigment epithelium development GO:0003406 IEA:Ensembl thyroid hormone generation GO:0006590 IEA:Ensembl thyroid hormone mediated signaling pathway GO:0002154 IEA:Ensembl ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl |
Binary Interactions |
Repeats | >MDP01976 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 9| 472.44| 50| 50| 1047| 1096| 1 --------------------------------------------------------------------------- 623- 657 (35.10/ 6.37) TL......YGS........SPlerQNSSSGS...PRMEICSGSN........KTK......KKKSS................. 945- 991 (56.90/16.15) ST......LAG........PG...LDSKPGK.R....SRTPSNDG.......KSKDKP..PKRKKA...DTEGK.SP.SHSSS 996- 1043 (48.68/12.46) TP......PTS........TG........GS.K.SPGSSGRSQTP.......PGVATPpiPKITIQ...IPKGTvMV.GKPSS 1045- 1094 (86.86/29.60) SQ......YTS........SG...SVSSSGS.K.SHHSHSSSSSS.......SSASTS..GKMKSS...KSEGS.SS.SKLSS 1095- 1145 (56.03/15.76) SM......YSS........QG...SSGSSQS.KnSSQSGGKPGSSpitkhglSSGSSS..TKM......KPQG......KPSS 1146- 1188 (45.96/11.24) LM....npSLS........KP...NISPS.......HSRPPGGSD.......KLASP.....MKPV.....PGTpPS.SKAKS 1189- 1222 (46.52/11.49) PI.........................SSGSgG.SHMSGTSSS..............S..G.MKSS...SGLGS.SG.S.LSQ 1224- 1277 (54.15/14.92) TPpssnscTAS........SS...SFSSSGS.S.MSSSQNQHGSS.......KGKSPS..RNKKPS...LT..A.VI.DKLKH 1278- 1339 (42.26/ 9.58) GV......VTSgpggedplDG...QMGVSTN.S.SSHPMSSKHNM.......SGGEFQ..GKREKSdkdKSKVS.TSgSSVDS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 74.07| 24| 77| 105| 134| 2 --------------------------------------------------------------------------- 105- 134 (33.97/38.80) SDMFYVevqlDPAgQLCDVKVAH....HgENPVS 185- 212 (40.11/23.70) SKMYYV....SPS.DLLDDKTASpiilH.ENNVS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 225.88| 60| 76| 719| 778| 3 --------------------------------------------------------------------------- 719- 763 (65.97/30.44) .......................................PVPHPQPSIQRMVRLSS...SDS...........IGPDV..TDILSD....IAEE..ASKLP.STSDD 764- 855 (74.84/35.67) CPAIG.....TPLRDSSSSGhsqstlfdsdvfqtnnnenPYTDPADLIADAAGSPS...SDSptnhffhdgvdFNPDLlnSQSQSG....FGEE..YFDES.SQSGD 872- 926 (56.93/25.12) VPMLGgdngeTKFKANNQAD...................TVDFSIISV.......A...GKA...........LGP........AD....LMEHhsGSQGPlMTTGD 1411- 1449 (28.14/ 8.18) ....................................................GSPShskSPA...........YTPQN..LDSESEsgssIAEK..SYQNS.PSSDD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 90.92| 27| 43| 250| 276| 4 --------------------------------------------------------------------------- 250- 276 (50.70/29.47) PSF.SSITSANSVDLPACFFL.KFPQPIP 292- 320 (40.22/21.74) PLFeTQPTYAPLYELITQFELsKDPDPIP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 100.07| 31| 66| 511| 548| 5 --------------------------------------------------------------------------- 511- 548 (46.90/37.26) GyGMTTGNNPmsgtTTPTNTFPggPI......TTLFNMSMS.IKD 578- 615 (53.17/23.39) G.GSTIGSSP....TPPHHTPP..PVssmagnTKNHPMLMNlLKD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYF 2) IRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDR 3) KITIQIPK 4) KPSLTAVIDKLKHGV 5) RLSPDFMIGEEDDDLMDV 6) SIKAKVTLQK 7) VAKIIISKH | 842 1451 1026 1265 1526 1368 1354 | 847 1483 1033 1279 1543 1377 1362 |
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