<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01975

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSASFVPNGASLEDCHCNLFCLADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEVTAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKISDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSFTDLDNLFNSDEDELTPGSKKSANGSDDKTSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGSAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAIMNRKFGNSSGLFLEDELDIIGRNTDCGKEAEKRFEALRGTSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASNKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENTDESANSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2174
PositionMiddle
OrganismPapio anubis (Olive baboon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Papio.
Aromaticity0.08
Grand average of hydropathy-0.393
Instability index53.07
Isoelectric point5.38
Molecular weight239376.43
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01975
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     194.39|      38|     421|     552|     589|       1
---------------------------------------------------------------------------
   31-   57 (33.75/11.17)	...KKYVWQGPTSAPILFP.VTEEDPI..L..S.SF.................................
  286-  310 (28.18/ 8.02)	..........PQSDIPTPS......PVGSThcSSSCLGV............................HQ
  554-  619 (54.62/22.96)	TPQSQHFYQMPTPDPLVPS.KPMEDRIDSL..SQSFPPQyqeaveptvyvgtavnleedeaniawkyYK
  620-  648 (37.81/13.47)	VPKKKDVEFLP...PQLPSdKFKDDPVGPF..GQ...................................
  977- 1005 (40.03/14.72)	TPQTHTSFGMPPSSAP.PS.N.............SGAGI.........................lpsPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.13|      22|      26|    1328|    1349|       2
---------------------------------------------------------------------------
 1328- 1349 (42.16/27.27)	P..EPLPIPTFLLGYDYDYLVLSP
 1353- 1376 (36.97/22.85)	PywERLMLEPYGSQRDIAYVVLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     666.21|     196|     425|    1511|    1727|       3
---------------------------------------------------------------------------
  794- 1012 (258.74/163.68)	.....LTPG.....SKKSANGSDDKTSCKESKTGNLDplSCISTADLHKmYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTV....LEGNSSSIGAQFKIEVDEGFCS.PK...................PSEIkdF.SYVYKP...ENCQILVGCSMFAPLKTLpSQYLPPIK.LPEeciYRQSwTVgKLELLSSGSAMPFIKEGDGSNMDQEYGP.AYtpqthtsfgmppssappsnsgagilpspsTPRFPTP
 1024- 1114 (103.73/57.47)	AGGPASAQG.....SVKYENSDLYSPASTPSTCRPLN..S.VEPATVPS.IPEAHSLYVNLI..........................................LSESVMNLFK...DCNFDSCCIcvcnmNIKGAD..VgVYIPDP................................................................................................................
 1511- 1727 (303.74/243.39)	SSTMTMTSGvaistSVATANSTLTTASTSSSSSSNLN..SGVSSNKLPS.FPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLqtagISGESSSLPTQPHPDVSESTMDRDKvgiPTDGDSHAI.....TYPPAI..V.VYIIDPftyENTDESANSSSVWTLGLL.RCFLEMVQtLPP...HIKS.TV.SVQIIPCQYLLQPVKHEDREIYPQHLKSlAF.........................saftQCRRPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.91|      13|      35|    1252|    1264|       4
---------------------------------------------------------------------------
 1252- 1264 (24.87/15.41)	DEALVKSSCLHPW
 1290- 1302 (24.03/14.61)	QDAIQKKRTVRPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.35|      41|     532|     660|     708|       5
---------------------------------------------------------------------------
  366-  417 (53.04/26.96)	KIPRKLANHVVDRvWQecnmnraqNKRKYSASSGGLCEEvtAAKVASWDFVE
  662-  702 (66.94/62.64)	KKPLKISDELVQQ.YQ........IKNQYLSAIASDAEQ..EPKIDPYAFVE
 1425- 1455 (39.37/22.08)	....KLSEKLVAE.W.............FSQAADGNNEA..FSKLKLYAQV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.84|      28|     282|     435|     503|       6
---------------------------------------------------------------------------
  463-  492 (46.06/75.06)	EKSEKPQKRPLTPfhHRVSVSDDVGMDTDS
  526-  553 (54.78/12.29)	EMANSPQPPPLSP..HPCDVVDEGVTKTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.44|      19|     714|     746|     766|      10
---------------------------------------------------------------------------
  746-  766 (32.19/23.50)	SLFS.PSIKqdAPRPASHARPP
 1472- 1491 (30.25/15.26)	SLLSqPNLV..APTSQSLITPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.42|      26|     816|    1186|    1215|      12
---------------------------------------------------------------------------
 1186- 1215 (45.14/33.20)	DDlillLQDQCTNLF..SPFGAADQDP...FPKSG
 2005- 2035 (41.28/21.76)	DD....LDPDIINILpaSPTGSPVHSPgshYPHGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     578.85|     189|    1726|      62|     273|      14
---------------------------------------------------------------------------
   62-  273 (305.76/242.46)	KADVLGV...WRRDQRpgrrelWIF.....WWGE..DPNFADL.IHHDLSEEEDGVWENGLS..YE.CRTLLfkAVHNLLERCLMNRnFVRIGK.....WFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPvyllsEEHITLAQQSNSPFQVilcpFGLNGTLTGQAFKMS...DSATKKLIgewkqFYPISCCLKEMSEE.KQEDMDW.....ED..DSLAAVEVLVAG
 1786- 2004 (273.08/169.33)	KYNVLFVgycLSHDQR......WILasctdLYGEllETCIINIdVPNRARRKKSSARKFGLQklWEwCLGLV..QMSSLPWRVVIGR.LGRIGHgelkdWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEP.....QGSFVIMPDSVSTGSV....FGRSTTLNMQTSQLNtpqDTSCTHIL.....VFPTSASVQVASATyTTENLDLafnpnNDgaDGMGIFDLLDTG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01975 with Med13 domain of Kingdom Metazoa
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