<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01953
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MTLPPSEPASSPRPCVSALSACAGGRAVRKMAASSSGEKEKERLGGGLGMASGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDFLLEPPGHNKENEDDVEIMSTDSSSSSSESD |
Length | 300 |
Position | Middle |
Organism | Papio anubis (Olive baboon) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Cercopithecinae> Papio.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.576 |
Instability index | 55.14 |
Isoelectric point | 5.25 |
Molecular weight | 32786.65 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
nucleoplasm GO:0005654 IEA:Ensembl
|
GO - Biological Function | thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
transcription by RNA polymerase II GO:0006366 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP01953
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 104.57| 27| 28| 85| 111| 1
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59- 79 (30.78/14.95) RLLSALE...D...LEVL..SR..ELIEMLA
85- 111 (47.46/25.97) KLLQAGE...ENQVLELLI.HRDGEFQELMK
114- 142 (26.32/12.01) ..LNQGKihhEMQVLEKEVeKRDSDIQQLQK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 84.07| 23| 23| 246| 268| 2
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246- 268 (44.66/26.85) LAPQYPWQSNDMSMNMLPPNHSS
272- 294 (39.42/22.94) LEPPGHNKENEDDVEIMSTDSSS
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|