<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01943

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGVCGSAIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVNSHSSHVISAQSTSSLPTTPAPQPPTSNTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGTPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKDVKPPPKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFVFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDSEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKAKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGTAPPSTEERKKKSTKGKKRSQPATKSEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQSSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQPQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2190
PositionKinase
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.07
Grand average of hydropathy-0.517
Instability index58.02
Isoelectric point6.78
Molecular weight244535.34
Publications
PubMed=15057822
PubMed=22673903

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	ISO:RGD
nucleus	GO:0005634	ISO:RGD
ubiquitin ligase complex	GO:0000151	IDA:RGD

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	ISO:RGD
protein C-terminus binding	GO:0008022	ISO:RGD
protein domain specific binding	GO:0019904	ISO:RGD
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	ISO:RGD
thyroid hormone receptor binding	GO:0046966	ISO:RGD
transcription coactivator activity	GO:0003713	ISO:RGD
transcription coregulator activity	GO:0003712	ISO:RGD
transcription factor binding	GO:0008134	ISO:RGD

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	ISO:RGD
canonical Wnt signaling pathway	GO:0060070	ISO:RGD
embryonic brain development	GO:1990403	ISO:RGD
embryonic neurocranium morphogenesis	GO:0048702	ISO:RGD
embryonic organ development	GO:0048568	ISO:RGD
endoderm development	GO:0007492	ISO:RGD
heart development	GO:0007507	ISO:RGD
neural tube closure	GO:0001843	ISO:RGD
neural tube development	GO:0021915	ISO:RGD
oligodendrocyte development	GO:0014003	ISO:RGD
positive regulation of transcription by RNA polymerase II	GO:0045944	ISO:RGD
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:RGD
positive regulation of transcription, DNA-templated	GO:0045893	ISO:RGD
post-anal tail morphogenesis	GO:0036342	ISO:RGD
protein ubiquitination	GO:0016567	IDA:RGD
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
Schwann cell development	GO:0014044	ISO:RGD
somitogenesis	GO:0001756	ISO:RGD
spinal cord development	GO:0021510	ISO:RGD
stem cell population maintenance	GO:0019827	ISO:RGD
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01943
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     244.61|      15|      15|    2056|    2070|       1
---------------------------------------------------------------------------
 1905- 1919 (21.38/ 6.14)	PTVPQGQ..RL....RQQLQA
 2056- 2070 (36.82/16.51)	QQQQQQQ..QQ....QQQQQQ
 2073- 2087 (36.82/16.51)	QQQQQQQ..QQ....QQQQQQ
 2092- 2108 (31.28/12.79)	QQQQQQQilRQ....QQQQQQ
 2109- 2123 (36.82/16.51)	QQQQQQQ..QQ....QQQQQQ
 2124- 2138 (30.91/12.54)	QPQQQQP..HQ....QQQQAA
 2141- 2155 (26.49/ 9.57)	QPQPQSQ..PQ....FQRQGL
 2156- 2174 (24.08/ 7.95)	QQTQQQQ..QTaalvRQLQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     273.79|      79|     345|     602|     705|       2
---------------------------------------------------------------------------
  614-  705 (126.53/86.83)	MYTCTLISRGDLAFGTPGPRPPSpfddpADDPERKEAEGSSSSKledPGL.SESMDIDPSSSVLFEDMEKPDFSLFSPTmpcegKGSPSPEKP
 1727- 1771 (85.68/36.17)	LYHTHLRPRPRAYYLEPLPLPP...........................................EDEEPPAPALLEPE.....KKAPEPPKT
 1774- 1822 (61.59/23.34)	................PGTAPPS.....TEERKKKSTKGKKRSQ...PATkSEDYGMGPGRSGPYGVTVPPDL....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.10|      28|     611|     523|     552|       3
---------------------------------------------------------------------------
  523-  552 (42.61/35.59)	AMVVAK...LLEK..RQAEIEA...ERCGESEAadEKG
 1134- 1169 (34.49/21.38)	AILIARqclLLEDliRCAAIPSllnAACSEQDS..EPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.09|      37|     233|    1597|    1654|       4
---------------------------------------------------------------------------
 1597- 1654 (49.97/65.10)	ADMSSISQgsmeenkraymnlvkklqkdLGERQSdSLEKVHQLLPLPKQNRDVITCEP
 1826- 1862 (71.12/41.60)	ANPGSISH....................LSYRQS.SMGLYTQNQPLPAGGPRVDPYRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     224.38|      67|     231|     746|     845|       5
---------------------------------------------------------------------------
  779-  845 (118.15/100.73)	ILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRN..RPEAFPTAE.DIFAKFQHLSHYDQHQV
 1224- 1293 (106.23/46.04)	VLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQggRNISVETASlDVYAKYVLRSICQQEWV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.81|      48|     610|    1356|    1426|       6
---------------------------------------------------------------------------
  406-  433 (30.52/ 6.61)	PMPEGNSAFTQQVRAKLrEIEQQIKERG.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1334- 1354 (20.19/21.41)	............................qavevrwsfdkcqeatagftigrvlhtlevldshsfersdfsnsldslcnrifglgpskdgheissdddavvsllcewavsckrsgrhramvvakllekrqaeieaercgeseaadekgsvasgslsapsapifqdvllqfldtqapmltdprseserveffnlvllfcelirhdvfshnmytctlisrgdlafgtpgprppspfddpaddperkeaegsssskledpglsesmdidpsssvlfedmekpdfslfsptmpcegkgspspekpdvekdvkpppkekiegtlgilydqprhvqyathfpipqeescshecnqrlvvlfgvgkqrddarhaikkitkdilkvlnrkgtaetdqlapivplnpgdltflggedgqkrrrnrpeafptaedifakfqhlshydqhqvtaqvsrnvleqitsfalgmsyhlplvqhvqfvfdlmeyslsisglidfaiqllnelsvveaelllkssdlvgsyttslclcivavlrhyhaclilnqdqmaqvfeglcgvvkhgmnrsdgssaercilaylydlytscshlkskfgelfsdfcskvkntiycnvepsesnmrwapefmidtlenpaahtftytglgkslsenpanrysfvcnalmhvcvghhdpdrvndiailcaeltgyckslsaewlgvlkalccssnngtcgfndllcnvdvsdlsfhdslatfvailiarqcllledlircaaipsllnaacseqdsepgarltcrillhlfktpqlnpcqsdgnkptvgirsscdrhllaasqnrivdgavfavlkavfvlgdaelkgsgftvpggteelpeeeggggssgrrqggrnisvetasldvyakyvlrsicqqewvgerclkslcedsndlqdpvlssaqaqrlmqlicyphrlldSEDGENPQRQRIKRILKNLDQ
 1372- 1423 (73.10/48.95)	PNTEMNSLLENIAKATI.EVFQQSAETG................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sssgSTASNMPSSSKAKPVLSSLER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.48|      25|     231|     217|     277|       8
---------------------------------------------------------------------------
  249-  277 (41.53/88.82)	MLDRHEFLTWVLECFEkirpGEDE....LLKLL
 1476- 1504 (37.96/ 8.42)	LLSQQPFLSLVLTCLK....GQDEqregLLASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.08|      29|     234|     321|     381|      10
---------------------------------------------------------------------------
  330-  358 (59.74/61.42)	PTTPAPQPPTSNTPST.P.FSDLLMCPQHRP
 1970- 2000 (49.33/ 8.55)	PPSYSSQPYQSTHPSTnPtLVDPTRHLQQRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.60|      33|     342|    1668|    1702|      12
---------------------------------------------------------------------------
 1668- 1702 (52.98/34.87)	GFDSIFK.....KEGLQVStkQKISPWELFEGLKPSTAPL
 1928- 1964 (49.00/26.38)	GQSSVHQmtpssSYGLQSS..QGYTSYVSHVGLQQHTGP.
 2014- 2032 (27.62/11.32)	..............GLTST..QRFS....HQTLQQ.TPMM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.27|      13|     233|     962|     974|      14
---------------------------------------------------------------------------
  962-  974 (24.61/14.03)	RSDG........SSAERCILA
 1190- 1210 (18.66/ 8.69)	QSDGnkptvgirSSCDRHLLA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01943 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLAFGTPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSV
2) FSPTMPCEGKGSPSPEKPDVEKDVKPPPKEKIEGTLGILY
3) LEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQSSQ
4) QQQQQPQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQ
5) RAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGTAPPSTEERKKKSTKGKKRSQPATKSEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTTVM
6) YVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQ
624
688
1890
2120
1737
1952
675
727
1947
2156
1888
2065










Molecular Recognition Features






MoRF SequenceStartStop




1) NIFGRY
2) QQQYHIRQQQQQQQILRQQQ
2185
2085
2190
2104