<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01934

Description Mediator complex subunit 14
SequenceMAPVQIGSDGPLVPLGGPVVSGPQPPPPGTPATQGVKLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAILFVDTADRLALLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKTEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEEKYVPAKYLTLSVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPALPACDSKLMERAMKIDHLSVEKLLIDSVHARAHQKLQELKAILKTSNPSDNSFIETALPTLVVPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKTVNDDMKRILSWLQQLRFWLGEQRCRQSVKHLPTVCSDILHLSNSATHPVGSLSKHKLFIKLTRLPQYYIVVEMLEVPSSPTALQYKYSFLSVSQLEGEDGPMCAQLLQLFKPNLEHLVQDPTTGREARPGTKRKIAGDQGDSEPKKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRAELSNMAIPNEGVQVEGDGSSHAIRLLRIPPCRDVGEETRRALERSLLDSTIRLQGRNNRTWVAELVLANCPLSSTNSKEQGASTRHVYLTYENPLSEPVGGRKVVEMFLNDWKAISQLYQCVLNFSCTLPEMPPYLSQFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSNTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVMQLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSSQDARRRSVNEDDNPPSPVGVDVMDSLMNQLQAQQQPQTMRGGAGGVYPPLTSPPPNYLANVTPSPSMMPTQSPDAGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGPLDPSSPYTMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPNSPRAGSGSQVMPTSMPPPRKLPQRPWAASIPTILSHNALHVLLLPSPTPCMVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEATLSIVNSNEPGVIMFKTDVLKCRVALNPKNYQTLQLKVTPENAGPWSQEELQVLERFFETRVAGPPFKFNTLSAFTKLLGAPTNVLRDCVRIMKLELFPDQAGQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKAKMLQLTQRIPVPQDPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALLVSNILKRFNELHPSRQGECTIFASVQELMASLTLPPSTRQ
Length1435
PositionTail
OrganismPoecilia formosa (Amazon molly) (Limia formosa)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Poecilia.
Aromaticity0.06
Grand average of hydropathy-0.186
Instability index51.23
Isoelectric point8.62
Molecular weight158603.51
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01934
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     134.26|      26|      29|    1021|    1046|       1
---------------------------------------------------------------------------
 1007- 1026 (25.75/ 7.85)	PL.TSP...............PPNYLanvtPSPSMM
 1027- 1053 (44.51/19.21)	PT.QSPDAGNIHASG.....SPSGAL..raPSP.FG
 1054- 1087 (33.61/12.61)	PT.PSPSSLGI.AMGqtsfaSPHGPLdpssPYTMVS
 1158- 1179 (30.38/10.65)	PTiLSHNALHVLLLP.....SP.........TPCMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.70|      29|     130|     973|    1002|       3
---------------------------------------------------------------------------
  973- 1002 (49.31/29.67)	PSPvGVDV..MDSLMNQLQAQ.QQPQTMRGGAG
 1103- 1134 (45.61/22.95)	PSP.GARIpgMSPGNPSLHSPiPDPNSPRAGSG
 1136- 1154 (26.78/ 9.52)	......QV..MPTSMP..PPR.KLPQ..RPWA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.06|      20|     130|     425|     459|       5
---------------------------------------------------------------------------
  282-  302 (33.51/10.50)	CLHSFCLSLQLEvLHSQTL..ML
  433-  454 (35.55/27.84)	CGRSECLHIFVD.LHSGMFqpML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     336.21|     114|     390|     135|     261|       6
---------------------------------------------------------------------------
   26-  166 (146.97/130.66)	PPPGTPATQGVKLSLLIEFLLQR..TyheitllAELLPRKTDMERKIEIVQFasRTRQLF...............VRLLALVKWASNAGKVEKCAMISSFldqqAILFVdtadrlallardalvhaRLPSFAIPF.AIDVLTTGSyprlPTCIRDKIIP
  167-  269 (116.83/113.58)	PDPITKTEKQTTLNQLNQILRHRlvT.......TDLPPQLANLTVANGRVKF..RVEGEFeatltvmGD.DPDIPWRLLKLEILVEDKETGDGRALVHSL....QVNFI...........helvqaRL...............................
  608-  675 (72.41/49.90)	...................................................................GDsEPKKPKR..SGEMCAFNKELAHLVAMCDT.....NMPFI.............glraELSNMAIPNeGVQVEGDGS....SHAIRLLRIP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01934 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SQDARRRSVNEDDNPPSPVGVDVMDSLMNQLQAQQQPQTMRGGAGGVYPPLTSPPPNYLANVTPSPSMMPTQSPDAGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGPLDPSSPYTMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPNSPRAGSGSQVMPTSMPPPRKLPQRPWA
2) VQDPTTGREARPGTKRKIAGDQGDSEPKKPKRSGE
958
586
1154
620










Molecular Recognition Features






MoRF SequenceStartStop




NANANA