<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01933

Description Mediator of RNA polymerase II transcription subunit 1
SequenceTRQQKDTKEAEKQSRMAALLERLHAKHNASRPWEGTINVVRQAMEKRSVMNEAGHQLLLNCLETLQRALKVSSLPSMTDRLESIARQNMLGSHLSTTKTECYITSDMFYVEVQLDTGGQLVDVKVAHQGENPTSCSELIQHLSEKNFEAFSKHLKGLVDLYRLPGDNKLKTKMYIALQSLELDLTKMMTMFRLATNANTVETILHGSVGWLTPRSGGNLVSLQCYVSPYDIFEVETGSQLSLPDNNVPRSLGVSVSVTIEGTSAVYKLPIAPLITGSHPVDNKGTPSFSTVSNSNSVDLPACFFLKMNRPMPFSLSFIQRLGSATSIPVFETPPPLSLLYQLIVQSQLQLLEEGSATPATLNNMHFYSILPDQHHCYFLNGDAPVQDGHSLQGAMVSKIPFRHPAHVPLLLDIIRHQAAYNTLIGSCVKRTSVKEDSAGLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMEVIDSRQVSCHLYKGPSDALICTDEFITKVVTRCMSIPVTMRAIRRKAETIQADTPALSLIAQTVETMVKNNPPPSGSPPYKMVGGDGTNPMGLPGLTGGNTPTGGGPPGGPNFAGPITSLFGMPRAERQAQEQQVHSDDYSKVTQNPILTSLLQITGNVGSSPSSQNAPQPHQTPPPTSSPASNTKSHPMLMNLLKDNPTQDFAALYSSSPLERQNSSSGSPRTDSMGGACPSGNTKGSSMPQHLQHHSVSHEDDFHRKLLSMDVDASQNSIFDVNLAGDSLDTHHSITPTLSQCGTPPPGSGMAYSQSHVQTQQQQPGSVPPRIVRLPSSDSIGPDITEILQELPEQTGKGSGGSHGQPEDGGPLGTPIRDSSSSGQGSAVFDSADIFNTNSNENPFTDAADLIAEAAATAATPNSDSSSTNFFPDASDFNPDLLTSGHGFSQSYFDDSSPSADGDMDLVKGFGGGSQQNTPSGTPQNPQHGQSTPEPSLKDPFDMGIVFGGNSGGGKPLLGQAPDLIDTHSGGSQSPLMMGLGGACSDFKTTDPKIKTGLIRPKDENGGNGGSGSGMGSSSAEGKQIKRSRTPSSEGKSKDKPPKRKKLDPDGKSPSHSSGGRPYTPPSGGSGSGGSISGGGSKSPGSSGRSQTPPGGATPPIPKITIQIPKGTITGGKTSSHSGYTSSSSATSSTGGVGGTSSSSKSHHSHSSSSGKIKSKEGSMTQSSSSKPGGSGGGGGQSQMKGSSQGMGVAKSGSSPITKHGLSGPGGAGGGMGSGSKIKPQGGKPPGSLMNPNIKPNISPSHSRSSSSGDKLSSPMKMQQSQVPGTPPSSKAKSPIGSGSGSSGGSKSSSGGSSQKPGGGGSSGSTSSSSTSSSGSMSFSGGSQSQYGSGAGQNNSNNPNSKGKSPSRNKKPSLTAVIDKLKSVGSGGVGEDGCEVGTPVGGPGSTSTPCGPGNVPSGPPNVGSSKHSSSSQSGDYKREKSDKDGKAKVMVTGGGSGDKKMMDPKTSGSGGTTLAKIIISKPDGGSPSIKAKVTLQKPGEGSGESIRQQISGLKASPLFSGSTPKHDRSSPSHSRSPGYTPLNQDSESESGSSSVAEKSHQNSPSSDDDQTVRPLPPQDYMSSIPLSSGEKHKKHKKEKKKLKDKERERSSSHSTKADSWSRSPISASDSSLSMLGSDRPSRSSPMYMRNEDDDLMDSALTGD
Length1672
PositionMiddle
OrganismPoecilia formosa (Amazon molly) (Limia formosa)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Poecilia.
Aromaticity0.04
Grand average of hydropathy-0.634
Instability index54.76
Isoelectric point8.62
Molecular weight173658.55
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01933
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     923.04|      95|      97|    1098|    1192|       1
---------------------------------------------------------------------------
  571-  693 (84.85/17.60)	NTP....T.GGGPPG....G....PNfagpITslFGM..PRAER..QA..............QEQQVHSdDYSKVtqnpilT...............SLL.....QI....TGNV.GSS...PSSQNAP....QPHQTPPP.....T....SSPASNTKShpmlmnllkdnpTQD..FAALY....S........SSPlerqnSSSGSP
  694-  784 (73.80/14.11)	RTD....SmGGACPS..........................GNT..KG..............SSMPQHL.QHHSV......SheddfhrkllsmdvdASQ.....NS....IFDV.NLA...GDSLDTH....HS...IT..............PTLSQC............GTP..PPGSG....M........AYS.....QSHVQT
  785-  892 (74.30/14.27)	QQQ....Q.PGSVP..........PR....I...VRL..PSSDS..IGpditeilqelpeqtGKGS.......GG......S...............HGQ.....PE....DGGP.LGTpirDSSSSGQ....GSAVFDSADIfntN....SNENPFTDA......adliaeAAA...TAA...............TP.....NSDSSS
  893-  997 (81.71/16.61)	TNF....F.PDASDF....N....PD....L............L..TS..............GHGFSQS.YFDDS......S..............pSAD.....GDmdlvKGFG.GGS...QQNTPSG....TPQNPQHGQ....S....TPEPSLKDP.....fdmgivfGGN...SGGGkpllG........QAP.dlidTHSGGS
  998- 1087 (83.11/17.05)	QSPlmmgL.GGACSD....FkttdPK....IK..TGLirPKDE...NG..............GNGGSGS.GMGSS......S...............AEGkqikrSR....TP.........SSEGKSK....D.KPPKRKKL...D....PDGKSPSHS............................................SGGRP
 1088- 1115 (51.50/ 7.06)	YTP....P.SGGSGS.............................................................................................................................................................GGS..ISGGG....S........KSP.....GSSGRS
 1116- 1216 (151.97/38.82)	QTP....P.GGATPP....I....PK....IT..IQI..PKGTI..TG..............GKTSSHS.GYTSS......S...............SAT.....SS....TGGV.GGT...SSSSKSH....HSHSSSSGKI...K....SKEGSMTQS.......ssskpGGS..GGGGG...qS........QMK.....GSSQGM
 1217- 1290 (71.63/13.43)	GVA....K.SGSS.P....I....TK....HG..LSG..P.GG...AG..............G.......GMGSG......S...............KIK.....PQ....GGKP.PGS.lmNPNIKPNispsHSRSSSSGDK...L....SSPMKMQQS.................................................
 1324- 1374 (71.37/13.34)	QKP....G.GGG..................................SS..............GSTSSSS...TSS......S...............GSM.....SF....SGG.............SQ....SQYGSGAGQ......................................NN....S........NNP.....NSKGKS
 1375- 1482 (80.56/16.25)	..P....S.RNKKPSltavI....DK....LK...SV..GSGGVgeDG..............CEVGTPV.GGPGS......T...............STP.....CG....PGNVpSGP...PNVGSSK....HSSSSQSGDY...KreksDKDGKAK.................vmVTGGG....SgdkkmmdpKTS.....GSGGTT
 1489- 1578 (98.24/21.83)	SKP....D.GGS.PS....I...kAK....VT..LQK..P......................GEGSGES.IRQQI......S...............GLK.....AS....PLFS.GST...PKHDRSS....PSHSRSPGYT...P....LNQDSESES..........gsSSV..AEKSH....Q........NSP......SSDDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.09|      29|      73|     282|     310|       7
---------------------------------------------------------------------------
  282-  310 (52.07/31.51)	NKGTPSFSTVSN....SNSVDLPACFFLKMNRP
  352-  384 (47.03/27.62)	EEGSATPATLNNmhfySILPDQHHCYFLNGDAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01933 with Med1 domain of Kingdom Metazoa
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