<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01924

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASAPIASVSEQPSTSTNPQLGPEPYFAYPTPTPEQLEEELPPYFENENVPLGLVLDRFARKGNHDLRVLLGEVLPQLPIRERPKPIIEYAKTTRQALLKYLAVLRWKTSVDIASTSAGSSVTNTAGPASFPTPHSNNDPNDNSPDAFAGKGKGKAQADELVIKGKVTDAKRIAHFMEHQNQQHEVAIEHVKHVTKVVEGLRERNPDLLTALSLLSTGTYNRLPTSLVDPYLAKPALTNSAILRVLRRLNRQIRYRLRCLDYFPPELIVEDIKDGRMYARGDGWRAELTVVGFEDTSRWWLTGVEWGWKAKEKGVDDPGGRVIKKFTGEERQGILDIANGEVLSPRELPDEKNEMEVDTVVTEDPQVKKSELVEVVKKTVDAPLLEVLFTQAIALSQGKWRGQLIPEMDRENKTLRLKYWLRERPVQVQRQDSTSNKRSQAPTTLATSRQPMVGGIIHISLAEKTTPRSELDNLLSDIACGGLVPSERVLKLKLGVKWVVDEAGDPDALSAEDLLHVCTRTHASHLTRSHGTSLLTSPRFLNASSVQPSLQESTDPSARPLTLRVPLPSRYAVSHLLIGVSPFSGLLEVEDEGAKGNDARAERATMSMKSVNEGKTKLVDDITRLTTAIVVENIEAQMRQLGWKPTRQIALRLKGIFRVVLLLNLGVSDISADLIKADLHPIITVFIPLASSPNHYFVAKAVQNGIVFELLKVAKVPNENGLGMRYIVGDRTMMDLGKLRARRKGGDDKPQRSAALVAQTIVEQQLKDRSIPYTQQFPPTTGPASPKSTSPLAGMVPTICVDVRDLLRAGRGGRSAAMEVAMPKVWLQIEGWWEGGKCEVVTIVVLRHQPSTVAPQTASQDSESKKDSAESVTAEGISFDPKSSIVRFRAKDISRCVPAFLEQWERLSKVIAVAGEVSRLNKTESFKDVKMLSFDLRTAVLQYAPGYNASITYSPTDDSYRITFFLSSPSSDTDRNPHELLAPLLSAKLNELTSTDIAGKNKAKGQVGREFMGLLKNTLPVLKLGKTLGIEKGWSMVVLGVAKYRLVKDHDGKRFAVDVTLLPDLEHYLIQDGATPRGPDHVVDVYTGPLTSLEMDKVIRAVFDTEKTISAETGDDEKIQGKNRRVPPVMKLDQGKSLVCEVERSERVLRKVMEEASKVMGLGNNMEMDS
Length1170
PositionTail
OrganismCryptococcus gattii serotype B (strain R265) (Filobasidiella gattii) (Cryptococcus bacillisporus)
KingdomFungi
Lineage
Aromaticity0.05
Grand average of hydropathy-0.344
Instability index38.12
Isoelectric point8.62
Molecular weight129357.66
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01924
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.04|      29|     103|       3|      45|       1
---------------------------------------------------------------------------
    3-   32 (52.18/22.82)	SAPIASVSEQPS..TSTNPQLGPEPyFAYPTP
  110-  134 (44.31/14.11)	SVDIASTS.AGS..SVTNTA.GPA...SFPTP
  545-  568 (27.55/ 6.63)	.......SVQPSlqESTDPSARPLT.LRVPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.33|      46|      95|     306|     400|       2
---------------------------------------------------------------------------
  333-  381 (70.34/90.47)	GILDIANGEVLSPR.ELPDEKNEMEVDTVVTEDPQVKkseLVEVVKKTVD
  455-  501 (72.99/20.25)	GIIHISLAEKTTPRsELDNLLSDIACGGLVPSERVLK...LKLGVKWVVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     302.23|      99|     105|     927|    1031|       3
---------------------------------------------------------------------------
  927- 1031 (157.59/102.55)	KDVKMLSFDL.RTAVLQYAPG..YNASITYSPTDDSYRItfflssPSSDTDRNPHELL....APLLSAKLNELTSTDIAGKNKAKGQVGRE..FMGLLKNTLPVLKL..GKTLGIE
 1032- 1141 (144.64/83.38)	KGWSMVVLGVaKYRLVKDHDGkrFAVDVTLLPDLEHYLI......QDGATPRGPDHVVdvytGPLTSLEMDKVIRAVFDTEKTISAETGDDekIQGKNRRVPPVMKLdqGKSLVCE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.11|      48|     530|     175|     321|       4
---------------------------------------------------------------------------
   43-   92 (76.66/14.56)	PYFEN...ENVPLGLVLDRFARKGNHDLRVLlgEVLPQLPIRERPKPIIEYAK
  230-  280 (78.45/145.97)	PYLAKpalTNSAILRVLRRLNRQIRYRLRCL..DYFPPELIVEDIKDGRMYAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.55|      11|      21|     283|     295|       6
---------------------------------------------------------------------------
  283-  295 (17.15/15.78)	GWRAELTvvGFED
  307-  317 (21.40/12.46)	GWKAKEK..GVDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.55|      20|     336|     190|     215|      10
---------------------------------------------------------------------------
  190-  215 (29.11/25.91)	HV......KHVTkvveglRERNPDLLTALSLL
  516-  541 (28.44/13.62)	HVctrthaSHLT......RSHGTSLLTSPRFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01924 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASAPIASVSEQPSTSTNPQLGPEPYFAYPTPTPEQLEEELPPY
2) TSAGSSVTNTAGPASFPTPHSNNDPNDNSPDAFAGK
2
116
44
151










Molecular Recognition Features






MoRF SequenceStartStop




1) EEELPP
2) QLGPEPYFAYPTPTP
3) YRITFFL
38
20
960
43
34
966