<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01917

Description Uncharacterized protein
SequenceMSTRPPQPGPRPPQRSLSGTGMLQRQAQQRSHLQQSQQQPSPGRASDSSAVEVIADGAETAPPRLEPSKPGGSMVRVEGLMAQKQNIVSMESPSPAGTPGAVMPLPKRARQRIPFRRHEAQSDAPKQVGSPQKSSANLPLPMPARPGRSGVSHIQKKAHDGGNSPKKETRPKPYVLEPPPDAPSYPSNGHLDYFPWTGTHNEDSFNDNVIRQGYFDKVQTGQNETASAKQQLYPSLRQKNGLQTLGSLFAHVLGQRRQHSQITAAPSFKPPPRVTLTDTKRETWLRDLANPLIPLRRLSRTIPHGIKNKVLLEQCTRKNVPTERAVWLAKCVGANEIRASKRKGVPGALAMGGESKWIRDWTVCVEQFVDGVVAAGGDKDWKLKVLYSIRLSAHLYSEQLLDTEHYLDWLLSSLESTPLTRLPIWLLIAEVYWADILRYRKSARRVVAALCSNLQDAHESPDRDLLLPLIERVGNILTATVRTNPESFIALSHWPKYCDTLEACNTSGGPDETQIFDAISRRNARLKSRSSGGDETQNSRRRVIDLLDASLSVQFSPDLPRECWKGMRDRTLLVQTLFDWATSCARPSLMKTFVAARLMRTWSRHGIDVDEAVLNYLTFRSNGPGVSSDAVYHLVSELARSGHFCVSKYIQWVIARGGLHGSQDVATDGPCVTRLLAELPVHDLPENLLRIRMTLLNRASFSVDNETETINNMSLAFERCSPNLYGKTPSGEEAPTTADVVQNITHLSRTVKAELGLQLRKQINLRMTKASPSEMGEWKADQEYETATTVTVADFNFTRAVLEATEDLSMLADILKLVSSSSSIQILASIADTLNMHRLTFSAIGALNDLFDTLVSRQFSLGAIQGPESVALLHSLCALSATIPDAANVHVQLSRDVARCVRRSAVDACSPVSDHVAEALQKSDGDISDEVDKLLSSGTSMDAPTLKRLFQVLINQMEASWAKSDSGLQKHGPILERLRTFDTKQFDNLLTPWVEQTILKSDRPNLSHVLGPLISAGCLSFKDVLKASVSSVQKTRDDSDKLMTSRIAFESLSLVLNTYRDGDIMSVEDAYTLNIRRTQAQFKDHLAILKIARTAIEISEPSIDNNDVTVNLLCQGDAFRRFLQRLVLTEFDCVLEEFVTPLAKSQDLHIITCLRAILRGLLDLKTTTTGPEDLVVARRIEVIFGVSSDLTLPFCQLALRSLSASEAPSSSSEAAADTSRLEAYERAVDAALANNNPTWTKIIPTLDPQIAQHLCDRAERSLLDTIPTFKPPSSDSPAPPQSPSDPALAKRMLFVISATAYSTQNLGSNTTALDIGEKINNLAHALSQPPTTDTYSETTTWLPLMLEYITTHASTLPSSRPATDVRARVLLALSALLLALHAHTGTDALSEHVLDVSLLLVDELPDDARAQCGRFLAERGKEVVLGDPGLRYVFGLESGGDGGALMINQRGKMEGFVVRRWECLSEPTPLVGENDAALSLSLFQARR
Length1487
PositionKinase
OrganismPseudogymnoascus sp. VKM F-103
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.06
Grand average of hydropathy-0.290
Instability index48.60
Isoelectric point7.05
Molecular weight163587.08
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01917
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.48|      38|     138|     733|     771|       2
---------------------------------------------------------------------------
  733-  771 (55.78/38.88)	EAPTTADVVQNITHLSRTV.KAELGLQLRKQInLRMTKAS
  783-  821 (54.70/33.43)	EYETATTVTVADFNFTRAVlEATEDLSMLADI.LKLVSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.32|      32|      38|     103|     139|       3
---------------------------------------------------------------------------
  103-  137 (51.06/32.01)	MPLPKRARqriPFRR..HEAQSDAPKQVGSPQKSSAN
  139-  171 (45.54/23.51)	.PLPMPAR...PGRSgvSHIQKKAHDGGNSPKKETRP
  176-  206 (55.72/30.84)	LEPPPDA....PSYP..SNGHLDYFPWTGTHNEDSFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.21|      14|      17|     894|     907|       4
---------------------------------------------------------------------------
  894-  907 (23.47/15.35)	SRDVARCVRRSAVD
  913-  926 (23.74/15.63)	SDHVAEALQKSDGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.45|      38|     138|     328|     377|       5
---------------------------------------------------------------------------
  340-  377 (68.88/70.56)	SKRKGVPGALAMGGESKWIRDWTVCVEQFVDGVVAAGG
  621-  658 (68.58/43.65)	SNGPGVSSDAVYHLVSELARSGHFCVSKYIQWVIARGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     292.50|      80|     107|    1021|    1100|       7
---------------------------------------------------------------------------
  929- 1003 (70.06/42.30)	................DEVDKLLSS.GTSMDAPTLkrlfqvLINqmeaSWAKSDSGLQKHGPILERLRTfdTKQF....D.NLLTPWVEQTILKSDR
 1021- 1100 (125.77/82.34)	FKDVLKASVSSVQKTRDDSDKLMTS.RIAFESLSL......VLN....TYRDGDIMSVEDAYTLNIRRT..QAQF...KD.HLAILKIARTAIEISE
 1131- 1206 (96.67/61.43)	FDCVLEEFVTPLAKSQD..LHIITClRAILRGL.L......DLK....TTTTGP....ED..LVVARRI..EVIFgvsSDlTLPFCQLALRSLSASE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     300.14|      89|    1056|     224|     312|       8
---------------------------------------------------------------------------
  224-  312 (157.68/82.88)	ETASAKQQLYPSLRQKNGLQTLGS.LFAHVLGQRRQ.HSQITAAPSFKPPPRVTLTDTKRETW..LRD..............LANP.LIPL...RRLS...RTIP.HG.....IKNKVLL
  540-  607 (30.15/10.16)	.................................RRRvIDLLDASLSVQFSP.....DLPRECWkgMRDrtllvqtlfdwatsCARPsLMKTfvaARLM...RTWSrHG.....I......
 1285- 1371 (112.32/57.01)	DPALAKRMLFVISATAYSTQNLGSnTTALDIGEK...INNLAHALS.QPPTTDTYSET..TTW..L...................P.LM.L...EYITthaSTLP.SSrpatdVRARVLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.14|      25|      52|      27|      51|       9
---------------------------------------------------------------------------
   27-   51 (42.50/24.61)	AQQRSHLQQSQQQPSPGRASDSSAV
   59-   79 (27.38/12.96)	ETAPPRLEPSKPGGSMVRVEG....
   82-  102 (35.26/19.03)	AQKQNIV..SMESPSP..AGTPGAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.37|      12|      26|     380|     391|      12
---------------------------------------------------------------------------
  380-  391 (22.17/11.78)	DWKLKVLYSIRL
  408-  419 (22.19/11.79)	DWLLSSLESTPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.41|      25|      29|    1225|    1252|      13
---------------------------------------------------------------------------
 1225- 1252 (36.38/31.04)	ERAvDAALANNNPTWTKiiPTLD.PQIAQ
 1256- 1281 (42.03/24.59)	DRA.ERSLLDTIPTFKP..PSSDsPAPPQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01917 with Med12 domain of Kingdom Fungi
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