<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01916

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMIIVSSRGGVQALTRLRGSHPPQGHSQSSVEIVVQGRWEQSSKVASSPTHRTLSFYLPSADALVTTNADVLEAAKIESQVQPRSGEERGGELRDGAGGAEGQVEGNMPGVIMENGYGTGAHTNHDRDGPPNRTNGAVQASSRPAEKTGMSVHQQPQNQSVQMNGASGAPMTQSAGHPAGSVSRDANIQAKSTPPEINHITEGFESLPNLLTRLAQVTHNQLSGKLLELAGMNIQQSPDNSNAVGFVSGPDDNSAENIKKKVNLLKFAEGVHSNWTKALVITQWSRISEEVSRVIDLKAHLDEQKLYYDIAVHELSEVKRSLVHARLPNPDLRTAVEVLSTGKASWMPDLGYIEPPPLTAKEILQSLQNLNTLLSIRLNLHDYDKIPYHFRNYTIKSGRVTFRVEGEFEVDLTIADEDPEKQFWFIDFRFLFSPSPSALTDQMRFSLEAKVNTVLEKDGLAGCYKVLHDLTLTHKISELRRQAYEIGRSRWIDSLMVEPLRRSLSIQYWVDRYGKEGPKSWIIIGVVSGKKKGAYPDEKETSRIGIRWFRDSKEVKDVEIPLELTALSVEGLLRSVITKHVSHILESMYKSLRTKPLYENRDLVLSFKKPTAAEQEPELHVQLTSQYKINVIVEYITGKFAISPSSRLTSQAEYRLNNQTVDPASNGHEYIENLHCVLISEDTVNRAYTVGWLPVRNPRLPQDELKPFLPRDTLQLSWFKKPGWDPNWYLALSSGMSGERWWLIEVTNVPEGPRPAADSIVLEGPTVRSHIQLPLKSVSPAPTYAFLSSLHLLSTSMISYYTNMRALHSRRAKFMLRNPSKSSLSSRQSQPALYVMLSTLLPSKNRSPRTGKPWAKDVLKVSFQGIETLEQKEAATSPAGGSSQSPSNPPTAPSGPIAPRQSEPEEGAIMIAEGHMETAIPAGLLVKQHVDKDIAFHPSTSAFAFRLQAKVGEPSITPLIERLQRVERLVDFVQVINAHPDSLHCESVSLSRLIFSYGCVQSPSPNQPKTESPRYQAIIDFSSQTTKLELQLEAGNPHIRILDHLTKILNSPLGLHGLATILPLTLPVLRALDAAEDSWEDIPSSELQILCRAADWYAVRYILTPPSEGDNKAPPPPKRIVFEIRLHRRGNVPWWCMRRDQKHNAATVDPLDLALKEKVWTGSEKGVWMGMQCAAIAQTGGAEAMVLRVDSAMRDLAKDGTVFANAAPGVTGVKGEGGAAEMTDVLGGQSGQMQAQVVNAPNKAQPQRPQTKSPVLQKQVQKKAQVPPTTQQQRTQAALNEAQHRAQYQAQQQARQKEMHRQAQIQARQGQGQQRPNPNNANGGNGNSGKQDAIVID
Length1336
PositionTail
OrganismPseudogymnoascus sp. VKM F-103
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.06
Grand average of hydropathy-0.471
Instability index50.77
Isoelectric point8.70
Molecular weight147740.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01916
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     169.27|      37|      37|    1256|    1292|       1
---------------------------------------------------------------------------
  870-  894 (30.71/11.13)	......QKE....AATSPAGGSSQSPSNPPTAPSG.......
 1228- 1249 (27.52/ 9.22)	....................QSGQMQAQVVNAPNKAQPQRPQ
 1250- 1291 (52.47/24.22)	TkspvlQKQVQKKAQVPPTTQQQRTQAALNEAQHRAQYQAQQ
 1292- 1330 (58.57/27.88)	Q...arQKEMHRQAQIQARQGQGQQRPNPNNANGGNGNSGKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.45|      34|      37|    1151|    1186|       2
---------------------------------------------------------------------------
 1151- 1186 (54.32/43.89)	DLALKEKVWTGS.EKGVWMGMqcAAIAQTGGAEAM..VL
 1189- 1225 (48.12/31.00)	DSAMRDLAKDGTvFANAAPGV..TGVKGEGGAAEMtdVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.28|      28|     107|     594|     624|       3
---------------------------------------------------------------------------
  594-  624 (45.39/36.17)	KPLYENRDLVLS.FKKPTaaeQEPELHVQLTS
  705-  733 (50.89/32.70)	KPFLPRDTLQLSwFKKPG...WDPNWYLALSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.73|      23|     107|     130|     190|       4
---------------------------------------------------------------------------
   94-  116 (42.41/58.20)	DGAGGAE.GQVEGNMPGVIMEN....GY
  163-  190 (30.33/14.41)	NGASGAPmTQSAGHPAGSVSRDaniqAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.45|      12|     107|     991|    1008|       6
---------------------------------------------------------------------------
  995- 1008 (20.72/ 9.08)	SYGCVQSPSPnqPK
 1106- 1117 (24.73/14.51)	SEGDNKAPPP..PK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.92|      22|     262|     283|     321|       9
---------------------------------------------------------------------------
  257-  278 (37.51/36.32)	IKKKVNL....LKFAEGVH..SNWTKAL
  294-  321 (26.41/24.83)	IDLKAHLdeqkLYYDIAVHelSEVKRSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.06|      15|      15|     776|     790|      12
---------------------------------------------------------------------------
  776-  790 (26.62/19.49)	SVSPAPTYAFLSSLH
  793-  807 (27.45/20.37)	STSMISYYTNMRALH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.76|      16|      21|     814|     830|      13
---------------------------------------------------------------------------
  814-  830 (25.60/18.84)	MLRN..PSKSSlSSRQSQP
  835-  852 (26.16/14.28)	MLSTllPSKNR.SPRTGKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.00|      35|     123|     423|     467|      14
---------------------------------------------------------------------------
  423-  467 (51.67/53.98)	WFIDfrflfspS........PSALTDqmrFSLEAKVNTVLEKDG...LAGCYKVLH
  547-  592 (49.33/28.65)	WFRD.......SkevkdveiPLELTA...LSVEGLLRSVITKHVshiLESMYKSLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01916 with Med14 domain of Kingdom Fungi
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