<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01904
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKTLDAQFLRVEKALATLVASISTYNPNPVLAHDLVAADQELSHGLADLATHQANYARIQSLKNTSSDLDAQIKGSLQLLSSTRSELLSTPATTFPSTTTSVSYTDLLSYARRISKFTLPPTYREAQPTPEPEGTGTQTNGTVTPTAPSNGAVVNVAELPVTPIQTDTDKTSLPPQIAEWLNPHNSAPGFVPWPTEETIRRGALASIQVLIDQGEDPATFDPERSAELEASRKRLEEEAERAKEEQQEAERARQEQRMREEHARREAMGAAGQRVEEKPKVFTGLDLLDDMDDDDE |
Length | 297 |
Position | Middle |
Organism | Pseudogymnoascus sp. VKM F-103 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes>
Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus>
unclassified Pseudogymnoascus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.662 |
Instability index | 43.63 |
Isoelectric point | 4.67 |
Molecular weight | 32603.61 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP01904
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 100.86| 31| 64| 96| 130| 2
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96- 126 (53.70/36.87) FPSTTTSVSYTDL..LSYARRISKFTLPPTYRE
148- 180 (47.16/22.92) APSNGAVVNVAELpvTPIQTDTDKTSLPPQIAE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 55.98| 18| 19| 241| 258| 3
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241- 258 (28.53/18.16) ERAKEEQQEAERARQEQR
262- 279 (27.45/17.21) EHARREAMGAAGQRVEEK
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