<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01900

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDDDMEVDIDDLFGDGAGGLLPPSRPPPKELFQRVDELRGSGCCQSIAWSRWGSIASITSNGLGLEFRNLRIHPKDGSWDLSDPTIIPQIAPIADGGQLKHLCWSPNGADLAAIDSAGRIAILNLAQSLNKPTFTRNSNVGPIEDLRAVVGAYWLNLSPSNVRQPGIQSVAVKTSTDYRYEISQAIAFGPCFPNAHKSALITVSTGGSLSLLWPQADGKWHELSSDIESISSSDDLITHASICADKNNTLLLAFATTAKKLSIARIAIKWGSPTANPPDRPVNPALNTVTPTIIIRLLSDTNWMDGSATDASDPFHLSPSMAALSHLSILSPSPDGPGGRPTSPTVITIRSHLPNSMSQYNQDTHSLINRWELSEASPSVHPAFEQLSARRNSVGSKPGPSPSLKKQEGFTSNKVVIWIEAIYFERIICFGYSDGSVEYRDRTSLAELFTLGGLDKFSHISQIGFTYNGYEPSLVGALSPTHLSVVQKGCDGKIKWNPLVYNMGEIGTSLEDTQYAAVIAGFSMACSTAIMNSSNHDDLMAAASKFKHLSSFAFDLVSEVSKTLKFNVDYSEESHHDSLIRNPSIQISLSIQNALGYNGDAHKRTFESKIAWISLQLRNCVVLITMAMNIRVPIPDQQKKVLGLEDSEVIRLLAGSVRWCLDLMSWLIDCLLHPEDPEVFESVTKGEDGSIPLLSAHLLATNNIALHVLLSSATRGFLTGICRRLAHLDYTARKAMSAAQSVSAPPGQSAPLISNSLRSSYTAIATLTASSIVPISRFEAFVARIADVVKEAYTAAKFPSQQQAQGAPGDSKRNNVEQGILFGAPLPEVMAPAISRIFSEELPKLRAEIDPSRLFFHDFGILGLPESNASAGKGAAEGSATTSSAQCKGISPGEAVEEMRKVCSGYGGYPQPDAAGAVPDHAAETLLLWRELGYPRGGEGGCLIVGC
Length947
PositionTail
OrganismPseudogymnoascus sp. VKM F-103
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.07
Grand average of hydropathy-0.104
Instability index45.41
Isoelectric point5.73
Molecular weight101815.14
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01900
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     263.69|      82|     219|     111|     328|       1
---------------------------------------------------------------------------
  177-  262 (131.47/225.42)	DYRYEISQaIAFgpcFPNAHKSALITVSTGGSLSLLWPQADG..KWHELSSDIESISSSDDLITHASICA............DKNNTLLLAFATTAKKLS
  455-  550 (132.22/35.00)	DKFSHISQ.IGF...TYNGYEPSLVGALSPTHLSVVQKGCDGkiKWNPLVYNMGEIGTSLEDTQYAAVIAgfsmacstaimnSSNHDDLMAAASKFKHLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.58|      22|     217|     583|     610|       2
---------------------------------------------------------------------------
  583-  610 (30.60/32.80)	PSiQislsiQNALGYNGDAHKRTFESKI
  799-  820 (40.99/25.14)	PS.Q.....QQAQGAPGDSKRNNVEQGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.95|      50|     217|      81|     160|       3
---------------------------------------------------------------------------
   81-  131 (82.77/37.53)	LSDPTIIPQIAPIADGG.QL..KHLCWSPNGA..................DLAAIDSAGRIAiLNLAQSLNK
  298-  327 (42.96/12.53)	LSDTNWMDGSA..TDAS.DP..FHL..SPSMA..................ALSHL.................
  676-  744 (54.22/ 9.34)	..DPEVFESVTKGEDGSiPLlsAHLLATNNIAlhvllssatrgfltgicrRLAHLDYTARKA.MSAAQSVSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.32|      23|     509|     374|     423|       8
---------------------------------------------------------------------------
  331-  353 (42.39/51.76)	SPSPDGPGGRPTSPTVITIRSHL
  401-  423 (39.93/10.62)	SPSLKKQEGFTSNKVVIWIEAIY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01900 with Med16 domain of Kingdom Fungi
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