<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01881

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDIGDYGTNVVCTYDLNSIAYSYFECSSETTTASTSSDLYKLVAELQQLGFLAAKDNKKSGLWIFEAGDTAEPASQPSGGAQLSSLASNLGLDLTSKHHGSYDSNALLESWKSLSKPPANTISSPSGDSGEPLSQKEAFERHFRAAQAAVLNKDAAANNSLIGLNNDAGASGLTLKDRARQFQLLAQSRLRLHIHDYFLTAVFLSLGFALCLDHGYIPLSSRTLVVPQSNLTTNESHTAAQNNNGQTDNHLQLVTLSSDYTGSKVLVIKATLSTSASYTGCDLSRYVKHEDVPIPANATLILGPGGSTGNYKGLASNGFQSAVSTYATDADESQHPGNEGQSSTSHRLKSRCLEWLVGKGLNRERLENSAWFMVEIYLSQLVNDARQSNNPRQGLSEERVLIPWPSFLCFRQTDNTLSSNDAFGTFSTYDPLEFAQSWYAGQQERDAVIIRRKKEREAAEAAAKAQVDSEAQDLHSLYSPLALRRSSVAGLVYPTPPDGVQHTVVATPTFDEAVSTPGQQGLPLSTDTSSSLVAKVEADASGPLDIASHTDFDFQDTSNGNLFGDAGDDLFGEENDITDADFSFFDEPDIFQGNQDVDMPGQDDTAEVVNNELTIGPKDDLNMDDGGEKEKADVHMGNTDESPVEASLPPDLPSDTNPAGQTEIKLEANLEEGPQTSADEPSPPLKPEYVFGRLSTFDVFSKPLLTKPQEDTSTVVLNPSGAFGGVDFKALFVSLHQKYGSHGRFIYPPPKVSPNTLRAKFPTTDYFNRRRRRKLAGKSSIVRGVHTGVENHFLVPGQVTNFETAGQRGSRSASPASDQDDSSDEMDGSFSLNSASLKRGHVDDNSESNDEDEIASSFQDLQVGPVDETINAALDTVYPFALDSDFARWSVAMFLAWPNPWENEYTLTDAEYIAAAQILGDQAISYTLRYPNDGNSDDTSLEESIKATYTPDLVRKDVVQAAKKYFKGAKATTLSGFLDIQGVPRQLAGINRLPPRPVQSAPGSQGSQGSQGSQGSQGSQGSNPVKPNPLFPLLSPHLELRRSDSKLTVLPSALPFWDVLGLAPRGNGKHVTSLCVFPKAVGMSESADLFLENIRSAYETRRLGSHERLNTESCVNGLLPIELGGQAARFASDQGLSVIREALFPVANHLAASTADSTNFVVYFVYDPESPDILVPICSAFHSMFEVYKKAMAGKTVSNELVLQLVPLSFVSARTHLVVLPPTDYARLAMEVYDRCFDFQSGVASPSVAIEPPLPRTIDFKLTANPSASLLQENSCLQIAYAQSIDERWITAAWSDNTGSEQMTASYCLGRQDAPLTRQFSDIAHEIWETTLDIIASKKVHWRIIIAKCGVMEAQDVRFWKGLSETERNAQISLTLLSVDTQPALQLLPPGLSMPASTLAAQSTFYTTPVSTPQASSILSPDQSGSTPTATPTEGGSELKIEPDATLIDLTNQSYGAVLAHRVNNSNSPLEVRPTAISGYLIKRTGASSSDIPAVMEVNIVWTDINPRLAENPLKEILAWYSGLATLARARGVVDPIKDTRPWHIAAAEKAVRLLYLLM
Length1559
PositionKinase
OrganismPseudogymnoascus sp. VKM F-4516 (FW-969)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.08
Grand average of hydropathy-0.335
Instability index42.51
Isoelectric point4.84
Molecular weight168895.81
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01881
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     816.31|     178|     188|     527|     714|       1
---------------------------------------------------------------------------
  259-  431 (172.73/92.60)	.................DYTGSKVLVIKATL...STS....ASYTGCDLsryvkhEDvpiPANATLiLGP.GGStgNYKGlASNGFQSAVSTYATDADESQhpG.NE............GQSSTSHRLKSrclEWLVG........KGLNRER.................LENSAWFMVEiylSQLV...NDARQSNNPrQGLSE...ERVL..IPWPSflcFRQT.DNTLSSNDAFGTFSTYDP
  527-  699 (282.38/158.35)	.................DTSSSLVAKVEADA...SGPLD.IASHTDFDF......QD...TSNGNL.FGD.AGD..DLFG.EENDITDADFSFFDEPDIFQ..G.NQDVD....MP...GQDDTAEVVNN...ELTIGPKDDLNMDDGGEKEKA.............DVHMGNTDESPVE...ASLP...PDLPSDTNP.AGQTEIKLEANLEEGPQTS...ADEP.SPPLKPEYVFGRLSTFDV
  700-  888 (198.99/122.80)	FSKPLltkpqedtstvvLNPSGAFGGVDFKAlfvSLHQK.YGSHGRFIY....ppPK...VSPNTL.RAKfPTT..DYFN.RRRRRKLAGKS.....SIVR..GvHTGVEnhflVP...GQ......VTN...FETAGQRGSRSASPASDQDDS.............SDEMDGS.FSLNS...ASLKrghVDDNSESND.EDEIASSFQ.DLQVGP......VDETiNAALDTVYPFALDSDFAR
  889- 1035 (162.22/88.70)	WSVAM..................................fLAWPNPW...................................ENEYTLTDAEYIAAAQIL...G.DQAISytlrYPndgNSDDTSLEESI...KATYTP..DLVRKDVVQAAKKyfkgakattlsgfLDIQGVPRQLAGI...NRLP...PR.PVQSAP.GSQGSQGSQGS..QGSQGS.....QG.SNPVKPNPLFPLLS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.34|      33|      38|     114|     147|       2
---------------------------------------------------------------------------
   71-  104 (29.36/12.51)	.....A..EPA...SQPSGGAqlsslasnlGLDLTSK....HHGSY.DS
  114-  147 (54.01/34.32)	LSKPPA..NTI...SSPSGDS.........GEPLSQKEAfERHFRA.AQ
  151-  187 (35.97/17.10)	LNKDAAanNSLiglNNDAGAS.........G..LTLKDR.ARQFQLlAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.72|      37|     921|     490|     526|       3
---------------------------------------------------------------------------
  490-  526 (68.63/35.14)	GLVYPTPPDGVQHTVVATP.TFDEAVS..TPGQQG.LPLST
 1391- 1431 (53.09/25.51)	GLSMPASTLAAQSTFYTTPvSTPQASSilSPDQSGsTPTAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.21|      10|      20|    1512|    1521|      10
---------------------------------------------------------------------------
 1512- 1521 (19.06/12.21)	NPLKEILAWY
 1535- 1544 (21.15/14.49)	DPIKDTRPWH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01881 with Med13 domain of Kingdom Fungi
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