<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01877

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMMDDDMEVDIDDLFGDGAGGLLPPARPPPKELFQRVDELRGSGCCQSIAWSRWGSIASITSNGLGLEFRNLRIHPKDGSWDLSDPTIIPQITPTVDGGQLKHLCWSPNGADLAAIDAAGRIAILNLSHSLNKPTFTRNSSVDPIEDLHAVVGAYWLNLSPSNLRQPGIQSVAVKTSNDYRYEISQAIAFGPCFPNAHKSALVTVSTNGVLSLLWPQADGKWHELSSDIEGISSSDDLITHASICADKNNTLFLAFATTAKKLSIARVAIKWGSPAANPPDRPVNPALNAVTPTIIIRLLSDTNWMDGSASDTSDPFHLSPSMAALSHLSILSPSPDGPGGRPTAPTVITIRSHLPNSLSQYNQDTHSLINRWELSEASATVHPAFEQLSARRNSTGSKPGPSPSLKKQEGFTSNKVVIWMEAICFERIICFAYSDGSVEYRDRSSLAELFTQGGEDKFSHITQIGFTYNGYEPSLVGAMSPTHLSVVQKGCDGKIKWNPLVYNMGDIGTSLQDTQYAAVIAGFNMACSTAIMNSSNHDDLMAAASKFKHLPSFAFDLVSEVSKTLKFNVDYSEESHHDSLIRNPSIQLSLSIQNALGYNGDAHKRTFESKIAWISLQLRNCVVLITMAMNIRVPTQDQSKKVLGLEDSEVIRLLAGSVRWCLDLMSWLIDCLLHPEDPEVFEAVAKGEDGSIPLLSAHLLATNNIALHVLLSSATRGFLTGICRRLVHLDYTARKAMSAAQSVSAPPGQSAPLISNSLRASYTAIATLTSGSIVPINRFEVFVARIAEVVKEAYTTAKFPSQQQTQGVPGGPGESSRNGIEQGVLFGGPLPDVMAPAISRIFSEELPKLRAEIDPSRLFFHDFSILGLPDSNTSSGKGSTGDNATSNSSYRLDAAGAVLDHAAEKVLLWWELGYPRRGEGGCLMLDRFGGDGQYYRIQYNAINVIRELAHAIDTRTG
Length957
PositionTail
OrganismPseudogymnoascus sp. VKM F-4516 (FW-969)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.07
Grand average of hydropathy-0.143
Instability index41.78
Isoelectric point5.77
Molecular weight103635.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01877
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.05|      51|      54|     292|     342|       1
---------------------------------------------------------------------------
  292-  315 (30.91/12.02)	..............................PTII.IR..LLS.......DTN.....WMDGSASDTSDP
  316-  383 (67.51/34.95)	F.HLSPSMAALSHLSILSPSPDGPGGRPtaPTVItIRshLPNslsqynqDTHslinrWELSEASATVHP
  385-  421 (49.63/23.75)	FeQLSARRNSTGSKPGPSPSLKKQEGFT..SNKV.V...............I.....WME.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.81|      42|      58|      16|      63|       2
---------------------------------------------------------------------------
   16-   63 (70.07/58.54)	DGAGGLLPPARPPpkELFQRVDelrgSGCCQSIAWSRWGS.IASITSNG
   77-  119 (74.75/46.11)	DGSWDLSDPTIIP..QITPTVD....GGQLKHLCWSPNGAdLAAIDAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.23|      30|      58|     682|     712|       3
---------------------------------------------------------------------------
  682-  712 (44.25/27.20)	EAVAKGEDGSIPLLSAHLLATNNiALHVLLS
  741-  770 (49.97/26.99)	QSVSAPPGQSAPLISNSLRASYT.AIATLTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.02|      53|     273|     187|     248|       5
---------------------------------------------------------------------------
  187-  242 (84.97/60.66)	IAFGpcFpNAHKSALVTVSTNGVLSLLWPQADG..KWHEL...........................SSDIEGISSSDDLITHAS
  464-  545 (79.04/36.12)	IGFT..Y.NGYEPSLVGAMSPTHLSVVQKGCDGkiKWNPLvynmgdigtslqdtqyaaviagfnmacSTAIMNSSNHDDLMAAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.39|      13|      15|     830|     842|       7
---------------------------------------------------------------------------
  830-  842 (24.05/15.87)	LPDVMAP.AISRIF
  846-  859 (19.34/11.16)	LPKLRAEiDPSRLF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01877 with Med16 domain of Kingdom Fungi
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