<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01876
Description |
Mediator of RNA polymerase II transcription subunit 17 (Fragment) |
Sequence | MSGIPDNFPMSLRPWPTKESNGSALPTLISRINAERGQFRNLTEEDLLEEIAKGESEAAADNDEMSTEDEVEAAPDRQKEVMDAKAEMLAQLEQAHHASMIALDFVALLLSKDQPVQAGLSISDGLRQVVSLGTLGADRVKDTRLTEPRKKDIAAVGKGWKIQSFNTSVESILNAASRLETEIAAETKYWEAILAVDEKGWKTCKLPQEQHTLGVRFGFFDAAPAFSNRSLAALRRQPDGTAYLDHGAADPTPKRVLIHIETNGILTGTLAPETTAPDSSPLETLVLRARNAVFEEELWQELNREARTLANHSVRMTGDEISCQLTPSTRILLRLEPLPTSAPAIAPVPRANDDIATMVSLALHLELSYAHRQNQRRRTQPPPPISS |
Length | 387 |
Position | Head |
Organism | Pseudogymnoascus sp. VKM F-4516 (FW-969) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes>
Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus>
unclassified Pseudogymnoascus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.405 |
Instability index | 50.97 |
Isoelectric point | 5.17 |
Molecular weight | 42515.49 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP01876
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 66.07| 19| 27| 240| 266| 1
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240- 258 (33.76/31.17) GTAYLDHGAADPTPKRVLI
268- 286 (32.31/12.64) GTLAPETTAPDSSPLETLV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 88.51| 31| 38| 129| 161| 2
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129- 161 (48.35/47.04) VVSLgtLGADRVKDTRLTEPRK..KDIAAVG.KGWK
169- 202 (40.16/30.71) VESI..LNAASRLETEIAAETKywEAILAVDeKGWK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 173.36| 59| 249| 44| 103| 3
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44- 103 (91.48/53.78) EEDLLEEIAKgESEAAADNDEMSTEDEV..EAAPD.R...QKEVMDAKAEMLAQLEQAHH..ASMIAL
295- 361 (81.88/43.80) EEELWQELNR.EARTLANHSVRMTGDEIscQLTPStRillRLEPLPTSAPAIAPVPRANDdiATMVSL
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