<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01872
Description |
Mediator of RNA polymerase II transcription subunit 21 |
Sequence | MADILTQLQTCLDQLATQFYATLCYLSTYHDHVPATVPPPGSGITDSMPSLAKIPRNQPSAAPMPAGAVAKQTAEQQGQASPSLGVSGAGGAGGGETSTLPPGANGAGMPSLIPGQGDPNQPPVPDSPQLFLYRQKELARDLIIKEQQIEYLIGRLPGIGSSEAEQEARIRELESELRQVEQAREKKARELKKLGKRLELVLGTVERGIYSKQRQGQD |
Length | 218 |
Position | Middle |
Organism | Talaromyces marneffei PM1 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces>
Talaromyces sect. Talaromyces.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.503 |
Instability index | 57.11 |
Isoelectric point | 5.81 |
Molecular weight | 23278.07 |
Publications | PubMed=25330172
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669
ECO:0000256 RuleBase:RU366036
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | |
GO - Biological Process | |
Interaction
Repeat regions
Repeats |
>MDP01872
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 80.74| 23| 59| 39| 65| 1
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39- 65 (39.43/28.32) PPGS.GitDSMPSLakIP.RNQPSAAPMP
101- 125 (41.31/19.55) PPGAnG..AGMPSL..IPgQGDPNQPPVP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 83.44| 28| 47| 134| 161| 2
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134- 161 (47.77/31.72) RQKELARDLIIKE.....QQIEYLIGRLP.GIGS
178- 211 (35.67/22.13) RQVEQAREKKARElkklgKRLELVLGTVErGIYS
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