<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01870

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHPSSTGLQTWTNQHRASGTTDRSSMAVARTPSSAQQLIDLSASDGPAEIEHSHKRPRLDTTVPGLGGDGRAPSSRSADARSATTGSNPTRPAAVSGRGRPAYSFQELVADTYGGSVFAGNSTPASQTSKPPSPPPFPVRPWTHTPARLSQVENEGISDNLRAREVQTVPYRPVTPEIAPNLTRDKVADYAPWSRTGNHPEDRLSDLNVKAGNFDRVPGPNTNSDIQSHASKLSSQLKNHSSLQLLSSVFAAALEKRQIHEKISSTSTFKPPPRVTLTDNKREAWLRDLANSSVPLRRLSRTIPHGIRGKVLLDQCLGKGVPIGRAVWLANVRLAARLFYEQLLDQDCYLDWYLSSMEGSSLDAFPIWLAMLSIYWGSLVRFRKRGRRLAEILLEKLREATSSEFKVNLQPLIERVSLLVRRLCRENSPCLILPRSWDRYQDIVASSLSDDSKEKAILQSLVLRNARVQRPGTCCPARQRSPQEQVIKLLDASRDTCNMCALSSSCLALIPDRQELVSVLLRWAASPFRQSLVRVYIAVRLFRKWKRSGMDIDACIFPFLTQTSMDQSTSSLTNVYHIIVELIRSQTFSVGRYLQWLVARGAVEQYRQQYSQASSVPVDIALLSHIPVARLPRHLRNLRDTLMARAGLPSSEAEVLHSIKADLKQRLPGLLGKDDFHMNINYDQNNLSWSVKADISQWIRAAVSEHYENGSAYHPKMYENNVEVSSLTQEEFLVVRSTLEQYGDLSMLADILIDASNSDDVRLLTCAVDTLNRHFECFTIIGALGDMFRSFYETFLRMKANGQPLYDLAYSMAEVGHRLPNEVNSLVLIRQELSRADRNLALAACSPVSDHMAETLNDASPSFNEDMDHFLSSGNSMDEMTMILVFQKLIQQLAFYDEKNPSMPGTVCRHLVQLRSFNSKHFDLLLVQWLEATLKSTSRPSLSRLLYPLVGIGCVTLPAFAALMKKLLQSGSLQTVNSALPDSLVDFLELLVLNNSAEPLRDFLTYRFHIAQEEFLQGHSHEVIALLKDAVPHMTLGTHDIISSVPCVVPLLSEIIVRHPDDATLDSIRTLMKNSPIFLPVVRKSLDLLLNDHRSNSDFLMETAITIKKTNHLSLPLCQMKLQILFEEKNDDSIRNNIVDLMYKSAVADVRAGNSYWLDLVSTMGQEAAEQLRQRAEKDFFSVAQSESAVEKDLENERLCLQENARVYLAIVDGLAYSIPEEGVPSVAPVLVEKMNTLLQKLFTMHMNVRNWSENRSRSSQEAMTLSLSGCEENFVFWLTSMLQMIRIHRAAFDLPVSAGNQRLGAYVDLSRLLIIICCLALSRTPLGLTVQPRLDLSASSYFLASAKEVRAGNTIQTYALDIASSLVDSLPDEARQHCANFIKERFPPALNVQNDPRLQYLFGPVAENIGNLGGALPSSMSVSSPAATLTPSNNPVNAATAAGGNTIEDPLALNNRLRVQSRGRVVGSYPVRPWEMLEEAAPVVGANDTAIDLNLFGARKVRDY
Length1507
PositionKinase
OrganismTalaromyces marneffei PM1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.07
Grand average of hydropathy-0.205
Instability index50.30
Isoelectric point7.38
Molecular weight167807.54
Publications
PubMed=25330172

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01870
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     909.48|     304|     364|     311|     674|       1
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  330-  660 (428.81/377.47)	........................................WlanVRLAARLFYEQllDQDCYLDWYLSSMEGSSL..DAFPIWLAMLSIYwGSLvrfrkrgRRLAEILL.....EKLREATSSEFKVNLQ....PLIERVSLLVRRLcRENspCLILPRSWDRYQDI......VASSLSDDskekaiLQSLVL.RN..ARVQRP...GTCCPARQRSPQeqviKLLDASRD.TCNMCALSSSC.....LALIPDRQELVSVLLRW.AASP.FRQSLVRVYIAVRLFrkwkrSGMDIDACIFPFLTQTSMDQSTSSLTNVYHIIVEL..IRSQTFSvgRYLQWLVARGAVeqyrqqysQA.....SSVPVDIALLSHIPVARLPRH..LRNLRDTLMARAGLPSSEAEVLHS
  661- 1022 (432.61/267.96)	IKADLKQRLPGL.LGkddfhmninydqnnlswsvkadisqW...IRAAVSEHYEN..GSAYHPKMYENNVEVSSLtqEEFLVVRSTLEQY.GDL.......SMLADILIdasnsDDVRLLTCAVDTLNRHfecfTIIGALGDMFRSF.YET..FLRMKANGQPLYDLaysmaeVGHRLPNE......VNSLVLiRQelSRADRNlalAACSPVSDHMAE....TLNDASPSfNEDMDHFLSSGnsmdeMTMILVFQKLIQQLAFYdEKNPsMPGTVCRHLVQLRSF.....NSKHFDLLLVQWLEATLKSTSRPSLSRLLYPLVGIgcVTLPAFA..ALMKKLLQSGSL........QT...vnSALP.D.SLVDFLELLVLNNS..AEPLRDFLTYRFHIAQEEFLQGHS
 1025- 1074 (48.06/22.07)	VIALLKDAVPHMtLG........................................................................................................................................................................................................................................................................................................................................................thdiiSSVPCVVPLLSEI.IVRHPDDatLDSIR.TLM...............
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.63|      37|      39|      58|      94|       2
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   32-   52 (21.65/ 8.65)	...............RTPSS.AQQLIDLSASDGPAEI
   58-   94 (62.34/41.73)	RPRLDTTVPGLGGDGRAPSSRSADARSATTGSNPTRP
  100-  136 (62.64/41.97)	RGRPAYSFQELVADTYGGSVFAGNSTPASQTSKPPSP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.83|      31|    1332|     139|     169|       3
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  139-  169 (57.27/34.03)	FPVRPWT..HTPARLSQVENEGISDNL.RAREVQ
 1472- 1505 (46.56/26.30)	YPVRPWEmlEEAAPVVGANDTAIDLNLfGARKVR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     244.78|      79|     204|    1151|    1232|       4
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 1151- 1232 (130.43/82.50)	DVRAGN...SYWLDLVSTMGQEAAEQLRQRAE...KDFFSVAQSesaVEKDLENERLC..LQEN.ARVYLAIVDGLAYSIPEEGV.PSVAPV
 1351- 1439 (114.35/65.84)	EVRAGNtiqTYALDIASSLVDSLPDEARQHCAnfiKERFPPALN...VQNDPRLQYLFgpVAENiGNLGGALPSSMSVSSPAATLtPSNNPV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.85|      25|      37|    1075|    1099|       5
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 1075- 1099 (41.19/28.00)	KNSPIFLPVVRKSLDLLLNDHRSNS
 1111- 1135 (42.67/29.31)	KTNHLSLPLCQMKLQILFEEKNDDS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01870 with Med12 domain of Kingdom Fungi
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