<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01861

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEEGLDVDDLFGDPNSLDLGLPTAQPTKGLAQRLDEMRLLGCCRKIAWSRLGCIAYISQDGLQVIVRHLACSPTDGKWALTEEYPQNQIAQLHLGQQLLHLCWNETGSDLAVLDASGRISILSIPAALNNLGISRQTVVDPPDDGAQVVGMMWMNSNRAVHAFHQAAKVNGRWNYSPYRRKPIGPFHPAGKPALICFTRNGIMRLLYQNPDQRWVEVSAELKTTNQSDRILTHAACLPSPNGILVATHSLSERLSLYRVQIMWNPPQWDQAQQRQASGVTPFPVPSIRIINCKTETPGRVFSFNKDQTDDLQNIAPNQSFLYQLTNLELVSGQFDNTGATTSPPCILAVYSSPYNSAAHDPQQQEPPASVMVRWQLETSTLNLHPIFEESLSKKTNGQQRTKLEIRRMEDIHFDKHVVSIDQIEFGCVLAITHDDSSVSFFDPKSMSQFTEGGDINAVTSIAQAGFRFPSDTPGLNICFSPNSCLAVVLDTDWQAQLRISDYNFEPEGDLHDDDLIMTISRHLSTDAQNVFVNEVYRALPINCNFSMEQDKPMQHPYVPRCLSLQAALGFQNFQTPRGLPSSVPWAVLHLRHASLLFAFFFQYSKQPKENETLDHDVLQMVYGNTKWALDFTQYLLNDLFSLAKEFEPILDDQEALAQKVKTTSSLSLTLVLATSPFAGDGRAYSKELYALIDSAPVRFNVYEKFLNSVESAIKNAYQRAGFGDDERRTPEKDILVNSRIPAVMIPVIVSLFKQTIPAIRTEVDQMSIYLTDYSWLGFCHDRRTEHYRQTRQVDIVKKVPLRGFDLSNGIIEPNVTSNGNKAGSSSRRRCVRCCEITGDPSSPRSMLYFQLTLRLQLIRNCLCGGMWTFEDGPPTTAGTAMATHKQVG
Length892
PositionTail
OrganismTalaromyces marneffei PM1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.09
Grand average of hydropathy-0.283
Instability index44.73
Isoelectric point5.90
Molecular weight99997.43
Publications
PubMed=25330172

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01861
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     333.25|     101|     108|     151|     257|       1
---------------------------------------------------------------------------
   87-  199 (125.62/101.35)	EYPQNQIAQLhLGQQLLHLcWNETGSDLA.VLDASGRisILSIPAAL.......NNLGISRQTVVDppDdgaQVVGMMWmNSNRAVHAfhQAAKVNGrwnYSPYRRKPIGPFH.PAGKPA.LI
  200-  305 (163.79/107.79)	CFTRNGIMRL.LYQNPDQR.WVEVSAELK.TTNQSDR..ILTHAACL....PSPNGILVATHSLSE..RlslYRVQIMW.NPPQWDQA..QQRQASG...VTPFPVPSIRIINcKTETPGrVF
  306-  363 (43.85/21.10)	SFNKDQTDDL.QNIAPNQS.FLYQLTNLElVSGQFDNtgATTSPPCIlavySSPYN..SAAH.............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.51|      31|      36|     445|     475|       2
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  445-  475 (54.43/43.01)	FDPKSMSQFTEGGDINAVTSIAQAGFRFPSD
  483-  513 (56.08/44.60)	FSPNSCLAVVLDTDWQAQLRISDYNFEPEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.32|      28|      28|     548|     575|       3
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  548-  575 (53.02/35.07)	NFSMEQDKPMQHPYVP...RCLSLQAALGFQ
  576-  606 (46.30/29.61)	NFQTPRGLPSSVPWAVlhlRHASLLFAFFFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.57|      58|     373|       9|      68|       5
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    9-   68 (95.61/53.12)	LDVDDLFGDpnSLDLGLPTAQPTKGLAQRLDEMRLLGCCRKIAWSRLGCIAYISQDGLQV
  385-  442 (97.96/49.18)	LNLHPIFEE..SLSKKTNGQQRTKLEIRRMEDIHFDKHVVSIDQIEFGCVLAITHDDSSV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.03|      33|      40|     617|     655|       6
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  617-  655 (51.06/50.99)	LDHDVlqmvygNTKWALDFTQYLLNDLF.....SLAKEFEPILD
  660-  697 (45.97/31.19)	LAQKV......KTTSSLSLTLVLATSPFagdgrAYSKELYALID
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01861 with Med16 domain of Kingdom Fungi
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