<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01859

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGDATTNFSAITGFSVIHWRIYTEEANTGNPSSDIAPNSGYNILRHLSRLKDLEIQLRNSDCLVSCYPRRLGLWIFSPTPGFESLSPLARDPAAQGLKESTKLIIGTSSLKVSAFGSITAVDLIRSLSTDGFTSVAGNPGHPARSIGAGVNAPRSGDAYANSMAIYASFITAMAGTIGLQLVKRHNAIPLGARTFYTAVERSFYDNPIISDANVESIPALTTLRIELTQAGKIVVALHTVRQDGISRLKEPGTVEISTANIQNNMDVWLAPNGTVARLITVNMAQSAVFAPKQAKSEGAARQITEAKQRVWKATVLEWLNNVGLPVDHPEDEHWVEVEVSEPFYARLAAEHLRQMDDSQSSSPLKRILWPSRYCFRRSKIASSSITEKIPQLAYDGEEPLHFAETWLETATSRHEKPKDNSSNIQKRSQNEAISGTIKFEVPEKIESLARVIHYPDLQNASSVYPTPPDGALAPGINPMHSDTLGPDGQDIGLSHTPAGETPMKQQENVRKASSDNPSFEHMNVMEVGTGLYDTNDDDELFSGMNDKDFGSKGITDADFSFFDDDDDDEMNDFLNDKPEPEPAQHDVLQPNPDDLIDVPVAQAEIQRDQLAPEDNVFEQDEMQQSNDVEASALSTVDTKQPSPTPPNATLREPALPPLEHIINAPLSPTDIKQMLFSNKDKTGQDERRRASASSNPGFEKKQSRYNAISFKRGLTLDQKYANAGRFFFTANKDNNENSGTIPGIPTIGFPSWRRSGHRGSVDEVNTSRQIGSEQHMQRTDSASSDESSLDSSDDDSEDETSPFRLATLKRKRPLSEAEKSTTSSMEKLSITSEVESHVSKEDTSIFLGNFFSVFTDWSLVGYFSAKQSQVSPVTSRKEDQMQVAQLMVDQLTQSSLSHKIEGWESDPELEYEALGLPTFLDDSTSLGENDRLDLKSYVTIHDIAQTTTETPSARPTPQRREVKGSITKIAPSHLRIHRGRDFLEVLSTSMPFWETFGLEPASGRKDVSAYCICPEFAKEEADAFMTRLGLLYSGCNLGKHVKGDMFETIDEGIGLWNIAKGDSSYARTMQALRGLCEDLASALSKAPQTGENFVIYIINPFSHGAAFVDICSSFLHLFHKYVGDVDKNQDKSQLNELVLQIVPLDFVFSPTSMVVPPQSQYLNLALEVYTRCPPKDSSHGIIGYAPPVVLADAVPKAINFRVTSEHFSPFQEGRCLHVAISRSVDQRWISVAWTNNSGSCQISMSYCVRARGSNVNRIISEVRQEIWEATKDLMERTQTRWKVLLVRTEPIDQEEIDAWTGFAERYNQAKALPVELIIFSANIAPGLRLEPSTTHFSVNTINPLTSTPVATPYGGVPSPDQLGAATPASGGQGPTTTNYNTAMTPTDTPPVLAEADSDAVLIDACEESWAVILSHRLNNSAYLTDYKPALVSGYLLRRKGVNDSQGVTAMSLNLVYTSRPPALHEAVLREALINYRDLSTLARAKGTLHVQHNTLPWHIATAVKGQELLSFVL
Length1516
PositionKinase
OrganismTalaromyces marneffei PM1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.07
Grand average of hydropathy-0.413
Instability index49.35
Isoelectric point5.13
Molecular weight166972.72
Publications
PubMed=25330172

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01859
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.90|      25|      65|     456|     480|       1
---------------------------------------------------------------------------
  417-  441 (35.92/19.06)	HEKPKDN.....................................SSNIQKRSQNEAISGTIK
  456-  480 (45.33/26.13)	HYPDLQN.....................................ASSVYPTPPDGALAPGIN
  487-  548 (22.65/ 9.08)	LGPDGQDiglshtpagetpmkqqenvrkassdnpsfehmnvmevGTGLYDTNDDDELFSGMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.07|      12|     293|    1165|    1177|       2
---------------------------------------------------------------------------
 1165- 1177 (20.04/15.64)	LNLALeVYTRCPP
 1453- 1464 (24.03/13.86)	MSLNL.VYTSRPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.53|      70|     293|     332|     415|       3
---------------------------------------------------------------------------
  332-  415 (104.35/97.33)	PEDEHWVEVEVSEPfyARLAAEHLRQMDDSQSS.............SPLKRILWpsrycfrrskiASSSITEkIPQLAYDGEEPLHFAETWLETATS
  615-  697 (110.18/68.66)	PEDNVFEQDEMQQS..NDVEASALSTVDTKQPSptppnatlrepalPPLEHIIN...........APLSPTD.IKQMLFSNKDKTGQDERRRASASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.69|      56|     395|     902|     958|       9
---------------------------------------------------------------------------
  902-  958 (91.90/62.23)	KIEGWESDPELEYEALGLPT.FLDDSTSLGENDRLD.LKSYVTIHDIAQTTTeTPSARP
 1298- 1355 (86.79/54.26)	EIDAWTGFAERYNQAKALPVeLIIFSANIAPGLRLEpSTTHFSVNTINPLTS.TPVATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.94|      32|     912|     273|     326|      12
---------------------------------------------------------------------------
  289-  326 (43.72/59.23)	SAVFAPKQaksEGAARQITEAK...QRvWKAtvLEWLNNVG
 1207- 1241 (57.22/25.18)	SEHFSPFQ...EGRCLHVAISRsvdQR.WIS..VAWTNNSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.21|      24|     614|     127|     150|      15
---------------------------------------------------------------------------
  127-  150 (44.42/25.02)	IRSLSTDGFTS..VAGNPG.....HPARSIG
  744-  774 (35.79/18.68)	IPGIPTIGFPSwrRSGHRGsvdevNTSRQIG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01859 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLQNASSVYPTPPDGALAPGINPMHSDTLGPDGQDIGLSHTPAGETPMKQQENVRKASSDNPSFEHMNVMEVGTGLYDTNDDDELFSGMNDKDF
2) ETWLETATSRHEKPKDNSSNIQKRSQNEAISGTIKF
3) KGITDADFSFFDDDDDDEMNDFLNDKPEPEPAQHDVLQPNPDDLIDVPVAQAEIQRDQLAPEDNVFEQDEMQQSNDVEASALSTVDTKQPSPTPPNATLREPALPPLEHIINAPLSPTDIKQMLFSNKDKTGQDERRRASASSNPGFEKKQSRYN
4) RFFFTANKDNNENSGTIPGIPTIGFPSWRRSGHRGSVDEVNTSRQIGSEQHMQRTDSASSDESSLDSSDDDSEDETSPFRLATLKRKRPLSEAEKSTTSSMEKLSITSEV
5) TPVATPYGGVPSPDQLGAATPASGGQGPTTTNYNTAMTPTDTPP
459
407
555
728
1350
552
442
709
837
1393










Molecular Recognition Features






MoRF SequenceStartStop




1) KGITDADFSFFDDDDDDEMNDFLNDKP
2) LKRILWPSRYCFRRSK
555
367
581
382