<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01855

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHPSSTGLQTWTNQHRASGTTDRSSMAVARTPSSAQQLIDLSASDGPAEIEHSHKRPSVFAGNSTPASQTSKPPSPPPFPVRPWTHTPARLSQVENEGISDNLRAREVQTVPYRPVTPEIAPNLTRDKVADYAPWSRTGNHPEDRLSDLNVKAGNFDRVPGPNTNSDIQSHASKLSSQLKNHSSLQLLSSVFAAALEKRQIHEKISSTSTFKPPPRVTLTDNKREAWLRDLANSSVPLRRLSRTIPHGIRGKVLLDQCLGKGVPIGRAVWLAKCVGANEIRAFKRKGTSGSLSQGLEIKWVREWTLSVQQFTAGVISACGKPDWRNKMTYAVRLAARLFYEQLLDQDCYLDWYLSSMEGSSLDAFPIWLAMLSIYWGSLVRFRKRGRRLAEILLEKLREATSSEFKVNLQPLIERVSLLVRRLCRENSPCLILPRSWDRYQDIVASSLSDDSKEKAILQSLVLRNARVQRPGTCCPARQRSPQEQVIKLLDASRDTCNMCALSSSCLALIPDRQELVSVLLRWAASPFRQSLVRVYIAVRLFRKWKRSGMDIDACIFPFLTQTSMDQSTSSLTNVYHIIVELIRSQTFSVGRYLQWLVARGAVEQYRQQYSQASSVPVDIALLSHIPVARLPRHLRNLRDTLMARAGLPSSEAEVLHSIKADLKQRLPGLLGKDDFHMNINYDQNNLSWSVKADISQWIRAAVSEHYENGSAYHPKMYENNVEVSSLTQEEFLVVRSTLEQYGDLSMLADILIDASNSDDVRLLTCAVDTLNRHFECFTIIGALGDMFRSFYETFLRMKANGQPLYDLAYSMAEVGHRLPNEVNSLVLIRQELSRADRNLALAACSPVSDHMAETLNDASPSFNEDMDHFLSSGNSMDEMTMILVFQKLIQQLAFYDEKNPSMPGTVCRHLVQLRSFNSKHFDLLLVQWLEATLKSTSRPSLSRLLYPLVGIGCVTLPAFAALMKKLLQSGSLQTVNSALPDSLVDFLELLVLNNSAEPLRDFLTYRFHIAQEEFLQGHSHEVIALLKDAVPHMTLGTHDIISSVPCVVPLLSEIIVRHPDDATLDSIRTLMKNSPIFLPVVRKSLDLLLNDHRSNSDFLMETAITIKKTNHLSLPLCQMKLQILFEEKNDDSIRNNIVDLMYKSAVADVRAGNSYWLDLVSTMGQEAAEQLRQRAEKDFFSVAQSESAVEKDLENERLCLQENARVYLAIVDGLAYSIPEEGVPSVAPVLVEKMNTLLQKLFTMHMNVRNWSENRSRSSQEAMTLSLSGCEENFVFWLTSMLQMIRIHRAAFDLPVSAGNQRLGAYVDLSRLLIIICCLALSRTPLGLTVQPRLDLSASSYFLASAKEVRAGNTIQTYALDIASSLVDSLPDEARQHCANFIKERFPPALNVQNDPRLQYLFGPVAENIGNLGGALPSSMSVSSPAATLTPSNNPVNAATAAGGNTIEDPLALNNRLRVQSRGRVVGSYPVRPWEMLEEAAPVVGANDTAIDLNLFGARKVRDY
Length1507
PositionKinase
OrganismTalaromyces marneffei PM1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.07
Grand average of hydropathy-0.193
Instability index49.67
Isoelectric point8.05
Molecular weight168446.74
Publications
PubMed=25330172

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01855
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     414.24|      76|     138|     597|     672|       1
---------------------------------------------------------------------------
  597-  659 (94.24/58.01)	..............................Q.......WLVARGAVEQYR..QQ.YSQA...SSVPV......DIALLSHIPVARLPRH..LRNLR.......DTLMARAG..LPSSEAEVLH
  733-  798 (60.77/34.45)	..............................E.......FLVVRSTLEQY...GD.LSML...ADILIdasnsdDVRLLT.CAVDTLNRH..FECF.........TIIGALG.dMFRSFYETFL
  799-  859 (70.23/41.11)	R..MKAN.GQPLYDL.......................................aYSMAevgHRLPN......EVNSLVLI.RQELSRA..DRNL.........ALAACSP..VSDHMAETLN
  864-  938 (70.35/41.19)	S..FNEDMDHFLSSG...............NsmdemtmILVFQKLIQQLA..FY.DEKN...PSMPG......TV.......C....RH..LVQLRsfnskhfDLLL......VQWLEATLKS
  939- 1021 (70.03/40.96)	T..SRPSLSRLLYPLvgigcvtlpafaalmK.......KLLQSGSL...........QT.vnSALP.......D.SLVDFLELLVLNNS..AEPLR.......DFLTYRFH..IAQEEFLQGH
 1022- 1082 (48.61/25.88)	SheVIALLKDAVPHM...................................tlGT.HDII...SSVPC......VVPLLSEI.IVRHPDDatLDSIR........TLMKNSPifLP........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.82|      69|     135|      41|     115|       2
---------------------------------------------------------------------------
   41-  115 (106.30/78.46)	IDLSASDGPAEIE.HSHKR..PSVFAGN......STPASQTS..KPpsPPPFPVRPwTHTPARLSQVENEGISdnLRaREVQTVPY
  170-  249 (98.52/53.79)	IQSHASKLSSQLKnHSSLQllSSVFAAAlekrqiHEKISSTStfKP..PPRVTLTD.NKREAWLRDLANSSVP..LR.RLSRTIPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.44|      33|     817|     493|     530|       4
---------------------------------------------------------------------------
  493-  530 (56.13/40.18)	DASRDTCNMCalsssCLALIPDRQEL.VSVLLRWAASPF
 1311- 1344 (53.31/28.84)	DLSRLLIIIC.....CLALSRTPLGLtVQPRLDLSASSY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01855 with Med12 domain of Kingdom Fungi
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