<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01854

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDSLPLAGNLSPSSFSVSNLKANRSPGISENLYPHTPTSPPLMSVGAQNYASNFAHTHTSPSHTTTSNGQPLSSPPSSTPMSTQNSQQPTVSVTTSFPTPASSVSGHPRNTTPADDSELADKSWGQGVQNSHATGNTDLGNVDKSGYRRTDHDRHRLPEGFDTEGRPQAADVDMMDIDSKEDNSSIRDSSLDALQQDIGMAFHLCKSGPDPSFDLISLYGLGPIGRSVMRADPTTGEKINRLRKSYEGKLKGLGLSGRNKAVKNENQAGGLRHLMMWPEEEWQIQKVHGKEIKVAEAESALQKLQMRAMKLEAGPLPNSEYWEDILGHEKSSKHTNVESGKRAVSTPNTLRPTVQTNGVPPTAAAPERARHTRGKKRHYDDNSFVGYGEGFVDDDDEGALYSNSEDRSGKKKRKKVFQPSHMSLQTGKLIYYSQEHISKMSPMPERTGSYGIGMYGIGAR
Length461
PositionHead
OrganismTalaromyces marneffei PM1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.06
Grand average of hydropathy-0.866
Instability index47.22
Isoelectric point7.32
Molecular weight50217.01
Publications
PubMed=25330172

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01854
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.63|      12|      37|      26|      62|       1
---------------------------------------------------------------------------
   26-   50 ( 9.55/17.75)	SPgisenlyphtPTSPPlMSvgAQN
   75-   86 (26.08/17.32)	SP..........PSSTP.MS..TQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.44|      15|      19|     110|     126|       2
---------------------------------------------------------------------------
  110-  124 (24.01/ 9.08)	RNTTPADDSEL..ADKS
  130-  146 (18.43/ 9.34)	QNSHATGNTDLgnVDKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.99|      20|      37|     281|     300|       7
---------------------------------------------------------------------------
  281-  300 (34.03/23.22)	EEWQIQKVHGKEIKVAEAES
  321-  340 (35.96/24.92)	EYWEDILGHEKSSKHTNVES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01854 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSDSLPLAGNLSPSSFSVSNLKANRSPGISENLYPHTPTSPPLMSVGAQNYASNFAHTHTSPSHTTTSNGQPLSSPPSSTPMSTQNSQQPTVSVTTSFPTPASSVSGHPRNTTPADDSELADKSWGQGVQNSHATGNTDLGNVDKSGYRRTDHDRHRLPEGFDTEGRPQAADVDMMDIDSKEDNSSIRDSSLD
2) SEYWEDILGHEKSSKHTNVESGKRAVSTPNTLRPTVQTNGVPPTAAAPERARHTRGKKRHYD
1
320
193
381










Molecular Recognition Features






MoRF SequenceStartStop




1) GKLIYYS
2) YGIGAR
428
456
434
461