<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01840

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceDEAMRKAGVAHNKSSKDMESHVFMKAKTREEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGGPTAGAPGMGMASRAQGAPMSGMSALGPMGQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQNQLQLQQIAQQQQQQQQQFQQQQVALQQQQFQAQQSAMQQQFQVQQQQAAAAAVAQQQQQQQQQLQAVQQQQQHMLKLQMQQQQNQQQMQQQQQQQQLQRIAQMQQLQAQAIQAQQQQQQQQQQQQQIPPQQIQQQPPQQVMQQQIQQMQQQQQQQQQQQQQQQQQQVAQAQQSQLPPQSQPQPQPMVSQPQAISGQIPSQVMPVTLTPQQLKAMQVRAQLVQQQQQAAAAVQAAQAQAAQMGASGQVPILYSLLLLLILSFPTFQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSGQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGPPITAPVASPRKRKYEEDERQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIKNPRQYAANPFLQSVYRYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length760
PositionTail
OrganismManacus vitellinus (golden-collared manakin)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Pipridae> Manacus.
Aromaticity0.03
Grand average of hydropathy-0.774
Instability index86.81
Isoelectric point9.68
Molecular weight84248.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01840
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.14|      31|      32|     231|     261|       1
---------------------------------------------------------------------------
  171-  201 (50.83/ 7.01)	QVQQQQAAAAAVAQQQQQQQQQLQAVQQQQQ
  231-  261 (64.93/11.14)	QMQQLQAQAIQAQQQQQQQQQQQQQIPPQQI
  266-  296 (56.38/ 8.63)	PQQVMQQQIQQMQQQQQQQQQQQQQQQQQQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.27|      24|      28|     424|     449|       2
---------------------------------------------------------------------------
  415-  448 (37.19/14.84)	PqsmppppqPQPSPQPGQPTSQPNSNVSsgPAPS
  470-  496 (30.08/ 6.82)	P.....qnfSVPSPGPLNTPGNPNSVMS..PASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.73|      19|      21|     127|     145|       3
---------------------------------------------------------------------------
  127-  145 (36.66/ 8.40)	QQNQLQLQQIAQQQQQQQQ
  298-  316 (32.07/ 6.10)	QAQQSQLPPQSQPQPQPMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.02|      33|     156|     520|     554|       4
---------------------------------------------------------------------------
  521-  554 (52.41/35.41)	MINKIDKNEDrKKDLSKMKSL.LDILTDPSKRCPL
  557-  582 (42.55/24.58)	L....QKCEI...ALEKLKND.MAVPTPPPPPVP.
  678-  707 (46.05/24.18)	LICKLD.....DKNLPNVPPLqLSVPADYPDQSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.90|      15|      15|      58|      72|       5
---------------------------------------------------------------------------
   58-   72 (28.24/13.25)	P.MNALQNLTG.....GPTAG
   74-   89 (24.14/10.17)	PgMGMASRAQG.....APMSG
   95-  113 (22.52/ 8.96)	P.MGQQMSLPGqqqppG.TSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.56|      19|     210|     148|     166|       7
---------------------------------------------------------------------------
  148-  166 (34.29/12.75)	QQQQVALQQQQFQAQQSAM
  329-  347 (28.31/ 8.81)	QVMPVTLTPQQLKAMQVRA
  352-  370 (27.96/ 8.58)	QQQQAAAAVQAAQAQAAQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.18|      12|     125|     586|     597|       8
---------------------------------------------------------------------------
  586-  597 (22.22/13.88)	QQYLCQPLLDAV
  713-  724 (20.96/12.59)	RQYAANPFLQSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01840 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IHNKKSQASVSDPMNALQNLTGGPTAGAPGMGMASRAQGAPMSGMSALGPMGQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQNQ
2) SQNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSGQSEEQQYLEKLKQ
46
396
130
510










Molecular Recognition Features






MoRF SequenceStartStop




NANANA