<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01821

Description Mediator of RNA polymerase II transcription subunit 8 (Fragment)
SequenceREEKQLELTLEALISQVADLKNSLVSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLLRNQVIIPLVLSPDRDEEIMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLITDAARISPDVAQKQIQSLNKMCSNLLEKISKEERESESGGLRQNKQTFNPADTNALVAAVAFGKGLSNRRPPGSGASVQSGQPGAGAIIAGASGMQQVPMSGAPAQQQPMLAGVQMAQAGQPGK
Length247
PositionHead
OrganismStruthio camelus australis
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Palaeognathae> Struthioniformes> Struthionidae> Struthio.
Aromaticity0.03
Grand average of hydropathy-0.458
Instability index49.39
Isoelectric point5.76
Molecular weight26922.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364144

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01821
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.15|      12|      27|     195|     206|       1
---------------------------------------------------------------------------
  195-  206 (23.78/12.55)	PGSGASV.QSGQP
  222-  232 (22.81/11.79)	PMSGAPA.QQ.QP
  233-  245 (17.57/ 7.62)	MLAGVQMaQAGQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.44|      25|      27|      65|      90|       2
---------------------------------------------------------------------------
   65-   90 (38.07/31.05)	KTPLLRNQViIPLVLSPDRDEEIMRQ
   94-  118 (44.37/31.28)	RVPVFSHEV.VPDHLRTKPDPEVEEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.49|      17|      28|       8|      24|       3
---------------------------------------------------------------------------
    8-   24 (25.46/16.03)	LTLEALISQVADLKNSL
   38-   54 (29.03/19.14)	LTWPSVLDSFALLSGQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01821 with Med8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVAFGKGLSNRRPPGSGASVQSGQPGAGAIIAGASGMQQVPMSGAPAQQQPMLAGVQMAQAGQPGK
2) FSHEVVPDHLRTKPDPEVEEQEKQLITDAARI
182
98
247
129










Molecular Recognition Features






MoRF SequenceStartStop




1) QPMLAGVQMAQAG
231
243