<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01810

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceDEAMRKAGVAHNKSSKDMESHVFMKAKTREEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGGPPAGAPGMSMASRAQGAPMTGMSGLGPMGQQMSLPGQQQPSGTSGMAPHGMPGVSTAAQPTQLQLQQIAQQQQQQQQQFQQQQVALQQQQFQAQQSAMQQQFQVQQQQAAAAVAAQQQQQQQQQLQAVQQQQHMLKLQMQQQNQQQMQQQQQQQQLQRIAQMQQLQAAQAMQAQQQQAQQQQQQQQQMPQQIQQQPPQQVMQQQMQQMQQQQQQQQQQQQQVAQAQQSQLPPQSQPQPQPMVSQPQAISGQIPGQVMPVTLTPQQLKAMQVRAQLVQQQQAAAAAVQAAQAQAAQMGASGQVPFLFSPLLLLIFSFSMFQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGPPITAPVASPRKRKYEEDERQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIKNPRQYAANPFLQSVYRYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length752
PositionTail
OrganismDryobates pubescens (Downy woodpecker) (Picoides pubescens)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Piciformes> Picidae> Picoides.
Aromaticity0.04
Grand average of hydropathy-0.734
Instability index85.34
Isoelectric point9.69
Molecular weight83166.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01810
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.18|      27|      28|     139|     165|       2
---------------------------------------------------------------------------
  139-  165 (55.95/13.67)	QQQQQQQQFQQQQVALQQQQFQAQQSA
  213-  236 (37.42/ 6.14)	QQMQQQQQQQQLQRIAQMQQLQAA...
  279-  297 (40.80/ 7.51)	QQQQQQQQ..QQQVA......QAQQSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.59|      32|     171|     166|     198|       4
---------------------------------------------------------------------------
  177-  210 (39.19/ 9.76)	AAAAVAAQQQQQQQQ..................qLQAVQQQQHMLKLQmQQQ
  264-  314 (41.40/ 7.72)	PPQQVMQQQMQQMQQqqqqqqqqqqqvaqaqqsqLPPQSQPQPQPMVS.QPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     133.83|      25|      28|      68|      92|       5
---------------------------------------------------------------------------
   70-   94 (47.12/17.94)	PAGA....PGMSMASRAQGAPMTGMSGLG
   95-  115 (27.26/ 6.99)	PMGQqmslPG.......QQQP.SGTSGMA
  319-  341 (27.20/ 6.95)	..QI....PGQVMPVTLTPQQLKAMQVRA
  348-  370 (32.25/ 9.74)	QAAA....AAV.QAAQAQAAQM.GASGQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.18|      25|      28|     437|     464|       6
---------------------------------------------------------------------------
  437-  462 (44.57/15.00)	PAPSPsSFLPSPSPQPSQSPAAARTP
  680-  704 (46.60/10.39)	PNVPP.LQLSVPADYPDQSPLWIKNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.18|      23|      23|     523|     545|       7
---------------------------------------------------------------------------
  501-  524 (29.91/14.53)	K......QLSKyIEPLRRMINKIDKNEDRK
  525-  547 (37.65/20.20)	K......DLSK.MKSLLDILTDPSKRCPLK
  548-  574 (23.62/ 9.91)	TlqkceiALEK.LKNDMAVPTPPPPPVP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.65|      32|     214|     372|     403|       8
---------------------------------------------------------------------------
  372-  403 (57.50/31.22)	FLFSPLL........LLIFSFSMFQVSQNNITMMSSP...SPV
  580-  622 (49.15/25.70)	YLCQPLLdavlanirSPVFNHSLYRTFMPAMTAIHGPpitAPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01810 with Med15 domain of Kingdom Metazoa
Unable to open file!