<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01803

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceDEAMRKAGVAHNKSSKDMESHVFMKAKTREEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGGPPAGAPGMGMASRAQGAPMSGMSGLGPMGQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQTQLQLQQIAQQQQQQQQQFQQQQVALQQQQFQAQQSAMQQQFQVQQQQAAAAAAAQQQQQQQQQLQAVQQQQQHMLKLQMQQQQNQQQMQQQQQQQQLQRIAQMQQLQAAQAMQAQQQQQQQQIPQQQIQQQPPQQVMQQQMQQMQQQQQQQQQQQQVAQAQQTQLPPQSQPQPQPMVSQAQAISGQIPSQVMPVTLTPQQLKAMQVRAQLVQQQQQAAAVQAAQAQAAQMGASGQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGPPITAPVASPRKRKYEEDERQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIKNPRQYAANPFLQSVYRYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length728
PositionTail
OrganismStruthio camelus australis
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Palaeognathae> Struthioniformes> Struthionidae> Struthio.
Aromaticity0.03
Grand average of hydropathy-0.806
Instability index84.97
Isoelectric point9.69
Molecular weight80467.34
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01803
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     203.37|      32|      32|     185|     216|       1
---------------------------------------------------------------------------
  159-  200 (52.00/ 8.44)	FQAQQSAMQQQfQVQQQqaaaaaaaqQQQQQQQQLQAVQQ.QQ
  201-  234 (54.16/ 9.12)	QHMLKLQMQQQ.QNQQQ........mQQQQQQQQLQRIAQmQQ
  236-  268 (50.03/ 7.82)	QAAQAMQAQQQ.QQQQQ.......ipQQQIQQQPPQQVMQ.Q.
  269-  293 (47.18/ 6.91)	......QMQQM.QQQQQ.........QQQQQQQVAQA.QQ.TQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.95|      27|      27|     374|     400|       2
---------------------------------------------------------------------------
  303-  329 (36.96/ 6.80)	Q...PMV.........SQA.QAI.SGQIPsQVMPVTLTPQQ
  358-  396 (39.83/ 8.13)	QmgaSGQvsqnnitmmSSP.SPVQQAQTP.QSMPPPPQPSP
  397-  426 (36.16/ 6.43)	Q...PGQ.......ptSQPnSNVSSGPAP.SPSSFLPSPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.39|      25|      28|      68|      92|       3
---------------------------------------------------------------------------
   58-   85 (41.34/17.09)	PMNALQNltgGPPAGAPGMGMASRAQGA
   86-  107 (36.56/14.21)	PMSGMSG..lGP....MGQQMSLPGQQQ
  108-  127 (32.49/11.76)	P.PGTSG...MAPHGMPGVSTATQ....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.53|      14|      22|     622|     635|       4
---------------------------------------------------------------------------
  622-  635 (24.62/12.34)	VARLNPKFLVNLDP
  647-  660 (26.92/14.06)	ICKLDDKNLPNVPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.42|      26|      28|     503|     529|       5
---------------------------------------------------------------------------
  494-  525 (34.46/20.72)	DKNEdrkkdLSKMKSLLDILTDPSKRCPlKTL
  526-  553 (44.96/23.75)	QKCE...iaLEKLKNDMAVPTPPPPPVP.PTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.18|      12|     126|     554|     565|       6
---------------------------------------------------------------------------
  554-  565 (22.22/11.32)	QQYLCQPLLDAV
  681-  692 (20.96/10.26)	RQYAANPFLQSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.77|      14|      15|     128|     141|       8
---------------------------------------------------------------------------
  128-  141 (26.44/ 7.95)	QTQLQLQQIA.QQQQ
  144-  158 (23.33/ 6.03)	QQQFQQQQVAlQQQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01803 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IHNKKSQASVSDPMNALQNLTGGPPAGAPGMGMASRAQGAPMSGMSGLGPMGQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQTQ
2) QVAQAQQTQLPPQSQPQPQPMVSQAQAISGQIPSQVMPVTLTPQQLKAMQVRAQLVQQQQQAAAVQAAQAQAAQMGASGQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQ
46
285
130
478










Molecular Recognition Features






MoRF SequenceStartStop




NANANA