<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01795

Description Mediator of RNA polymerase II transcription subunit 1 (Fragment)
SequenceEAEKLNKMSSLLERLHAKFNQNRPWTETMKLVRQVMEKRVVMNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLSKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEEGTGVPIVLHENNVPRSLGMNVSVTVEGTMAMYKLPIAPLIMGSHPVDSKGTPSFTSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQGCTGIPLFDTSPTFVPLYELITQFELSKEADPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTLGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRIPTDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPTTNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYASQALSTLGVQVLGGDGGENKFKGSNQSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKESNGSGSNMAGPGLDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLSSSQGGSSSGQSKSSAQSVGKPGSSPITKHGLSSGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSAASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDSLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSIKPESWSKSPISADQPLSMTSSAIISAERPSRASPEFLIGEEDDDLMDVALIGN
Length1574
PositionMiddle
OrganismStruthio camelus australis
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Palaeognathae> Struthioniformes> Struthionidae> Struthio.
Aromaticity0.04
Grand average of hydropathy-0.647
Instability index53.90
Isoelectric point8.89
Molecular weight167324.13
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01795
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1199.21|     184|     184|    1100|    1283|       1
---------------------------------------------------------------------------
  550-  666 (166.27/38.48)	SGTttpTNTFPGG...PITTLFNMSIS...MKERH...DSVGH.....................GE...D..............................FSKV..SQNPILT...........SLLQITGNVG......ST......LGS...SPTP..PHHTPPPVSSPASNTK....NHPMLMNLLK..ENPPQDFS...........................................................TLYGS...SPLERQNSSSG
  667-  843 (191.22/45.42)	SPR...MEMGPGG...NKQKKKKSRI..PTDKPKH...QTEDDfqrelfsmdvdsqnpifdvnmTA...DTLDTPhITPA.............PsqcSTPPTTY..PQ.PI.............PH.....SQP......SIQRMV.RLSS...SDSI..GADVTDILSDIAEEAS....KLPTT..........NEDCPP.I......GTP...VRDSS....SSGHSQSALFD.P.DVFQTNNSE..NPYTDPADLIADAAV...SP......NSD
  844- 1000 (161.32/37.10)	S.S...NHFFPDGvdfNP.DLLN.SQSQSGFGEEYfdeSSQSG.....................DT...DDF.....KG..............Y...ASQALST..LGVQVLG.GDGgenkfkGSNQSDTVDFS......IIAAASkALGS...SDIM..EHH.......SGGQSP....LLNTGD..........................lGKEKSQKrvkeSNGS.GSNMAGpGLDGKPGKRSR..TPS.SD....GK.........SKEKLPK.
 1001- 1157 (214.20/51.81)	..R...KKQETDG...K..............SPSH...S..................................SS.NRPF..................TPPASTggSKSP....GSS......GRSQTPPGVATppipkiTIQIPK.GTVT...VGKP..SSHGQYTSSGSVTSSS....SKSHHSHSSS..SS....SSSSS......STS.GKIKSSK....SEGSSGSKMSS.SLSSSQGGSSS..GQSKSSAQSVGKPGS...SPITKHGLSSG
 1158- 1340 (290.61/73.05)	SGS...TKMKPQG...KPSSLMNPSMSKPNISPSH...SRPSG.....................GS...DKLASP.MKPV.............P...GTPPSSK..AKSPISS.GSG......GSHMSGTGSSS......SMKSSS.GMGS...SGSM..SQKPPPSSNSSAASSS....SFSSSGSSMS..SSQNQHGSSKG.....kSPS.RNKKPSL....TAVIDKLK.HG.VVTSGPGGEDPmdGQMGPSSNSSSHTMS...S...KHNMSGG
 1341- 1539 (175.59/41.07)	.........EFQG...KR........EKSDKEKSK...VSVSG.....................GSvdsSKKTSD.SKNVgstgvakiiiskhD...GGSPSIK..AKVTLQKpGEG......G....GDSLRP......QMASSK.SYGSpliSGSTpkHERCSPSHSKSPAYTPqnidSESESGSSIAekSYQNSPSSDDGirplpeYSS.EKHKKHK....KE...KKKVKD.KDRDRDRDRDK..DRDKKKSHSI.KPESwskSPISADQPLSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.29|      12|      37|     195|     209|       3
---------------------------------------------------------------------------
  195-  209 (17.78/17.74)	ILHGSVgylTPRSGG
  233-  244 (22.51/11.74)	VLHENN...VPRSLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01795 with Med1 domain of Kingdom Metazoa
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