<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01791

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceAELTGIKWRRYNFEGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVDVIHRELHMVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFIRPYDKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPSPFQVLVSPYGLNGTLTGQSYKMSDPATRKLMEEWQYFYPMVLKKKEGMKEEEELGYDNDFPVAVEVIVGGVRMVYPSAFVLISQSDIPMSQSAANTGGHINVGQQGLGSVKDPASTCGMPLTPPTSPEQAIIGESGGSQSTISHSTVQEGTVSVHSPKKSGKIPPKFHNHMVHRVWKECILNRSQSKRSQVTTANMEEEVPNDTVSWDFVDPVERVSCSCSRHKVFKQRCAAGSSRPPTVTQPGFSVGTSSSSSLPPPASSKHKTTERQEKGDKLQKRPLMPFHHRPSVTEELCMEQDTSGQKLGLEGKAPSSNSRKYEKPLSIPARNPSKQINMNPMDSPHSPTSPLPPTLSPQPRGQEAENLDPPSVPVNPALYGNGLELQPLPSLDDRTVLVGQRLPLMAEVSETALYCGIIHNNESLDMWRTYSVPPSDDPEFRPPDLPCERYDAKMEVNSDSTALKRLLAQPNKRFKILEDSKPAQTLNYLDPLPLIHQPGEGLGDASDPYTFEDGDIKYSFTGNKKCKLGAEKDPLKKSKSEDGIGTKEIPTTGHSTPVPDGKDAMSIFSSAPKTDTRQDNAAGRVGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVNMVPTQLAEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSIFAPLKILPSQCLLPLKIPDACIFRPSWAVPPKIEQLPLPPAATFIRDGYNNVPSVGSLADQDYLQMNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQPIPEAHSLYVTLILSDSVLNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFIEDELDIFGKTSDIGQAAERRLMMCQSNLLSQMGEGARRTQEPPMSLLLLLQNQHTQPFTSLSCLDYMSSNNRQTLPCMNWSYDRLQADSNDSWIECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGTYTVLYTNTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLDGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWGTEECDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLLPPKYHTPAPASQTQTVPGNTGSAPSNSTCLSAPGAPSTGNSFNSTPSGGTTSLPAGSSSSSGSSVPQLSASSATPSVNQMTTTSTPGFSGNVCPGQNTSTGGNTADRLQGSTGPGGDIESGQNLPQQQQEGQEGVTERERIGVPTEPESADSNAYPPAVVIYMVDPFTYTADEESASANFWLLSLMRCYTEMLDNLPENMRNSFILQIVPCQYMLQTMKDEQVFYIQHLKSLAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIDLPNRSRRSKLSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKEVCRMCGISSADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPTNDDMFDLPFPDDIDNDFGILITGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNIL
Length2176
PositionMiddle
OrganismStruthio camelus australis
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Palaeognathae> Struthioniformes> Struthionidae> Struthio.
Aromaticity0.07
Grand average of hydropathy-0.398
Instability index58.72
Isoelectric point5.68
Molecular weight239323.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01791
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     336.70|      86|      92|     431|     522|       1
---------------------------------------------------------------------------
  434-  526 (131.47/79.61)	SSLPPPASSKHKTTErQEK.............GDKLQKRPLmpFHHRPSV.....TEELCMEQDTSGQKLGLEGKAPSSNSRKYekpLSIPARNPS....KQINMNPMDSPhSPT
  527-  616 (109.26/52.23)	SPLPPTLSPQPRGQE.AENldppsvpvnpalyGNGLELQPL......PSL.....DDRTVL....VGQRLPL..MAEVSETALY...CGIIHNNESldmwRTYSVPPSDDP....
  957- 1028 (95.97/44.89)	.PLPPAATFIRDG..............................YNNVPSVgsladQDYLQMNTPQMNTPVTLNSAAPASNSG.....AGVLPSPAT....PRFSVPT...PrTPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.29|      14|      19|    1575|    1592|       2
---------------------------------------------------------------------------
 1575- 1588 (27.81/19.38)	GNVCPGQNTSTGGN
 1595- 1608 (26.49/ 8.30)	GSTGPGGDIESGQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.21|      12|      17|    1204|    1215|       3
---------------------------------------------------------------------------
 1204- 1215 (22.19/12.41)	QNQHTQPFTSLS
 1223- 1234 (25.01/15.08)	NNRQTLPCMNWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     598.77|     193|     427|     204|     432|       4
---------------------------------------------------------------------------
  204-  428 (306.70/256.05)	SD.PATRKLMEEWQYFYPMVlkkkEGMKEEEELGYDNDFPVAVEVIVGGVRMVYPSAFvliSQSDIPMSQSaANTGGHinvgqqgLGSVKDP....ASTCG.....MPLTPPTSPEQAiiGESGGS..QSTISHSTVQE...GTVSVHSPKKSGKIPPKFH..NHMVHRVWKECILNRSQSKRSQVTTANMEEEVPndtVSWDfvdpvervscscSRHKVFKQRCAAGSSR....PPTVTQ.PGFS.V
  636-  851 (292.07/180.17)	SDsTALKRLLAQPNKRFKIL....EDSKPAQTLNYLDPLPLIHQPGEGLGDASDPYTF...EDGDIKYSFT.GNKKCK.......LGAEKDPlkksKSEDGigtkeIPTTGHSTPVPD..GKDAMSifSSAPKTDTRQDnaaGRVGSGSLTQVTDLAPSLHdlDNIFDNSDEDELGAVSPALRSSKMPAVGSEERP...VGKD............GRTAVPYPPTVADLQRmfptPPSLEQhPAFSpV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     252.98|      87|     411|    1624|    1739|       5
---------------------------------------------------------------------------
 1624- 1739 (121.63/119.56)	ERIGVPTEPESADSNaypPAVVIYmvdpFTYTADEESASANFW................llslmrcytemldnLPenMRNSfilQIVPCQYMLQTMKDEQVFYIQHLKSLAFsVYC....QCRRP.LPtqIHIKSLT
 2045- 2166 (131.34/69.23)	ERLLSREAPEELKQQ...PLALGY....FVSTAKAENLPQWFWsscpqaqnqcplflkaslhhhisvaqtdelLP..ARNS...QRVPHPLDSKTTSDVLRFVLEQYNALSW.LTCnpatQDRSScLP..VHFVVLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.34|      62|     411|     863|     956|       6
---------------------------------------------------------------------------
  890-  956 (107.84/88.52)	DGLGSPkpeeiKDFSYVHKVPSFQPFV.GS.SIFAPLKILPSQCLL....PL.KIPDACIFRPSWAVPPKI.EQL
 1370- 1439 (85.49/31.95)	DPYGGH.....RDVAYIVVCPENEALLdGAkTFFRDLSAVYEMCRLgqhkPIcKVLRDGIMRVGKTVAQKLtDEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.28|      14|     411|    1447|    1460|       8
---------------------------------------------------------------------------
 1447- 1460 (30.07/17.03)	PW....GTEECDNHSRLK
 1860- 1877 (22.21/10.51)	PWrvviGRLGRLGHGELK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.29|      16|      19|    1507|    1522|       9
---------------------------------------------------------------------------
 1507- 1522 (29.15/11.13)	SAPSNSTCLSAPGAPS
 1529- 1544 (28.34/10.59)	STPSGGTTSLPAGSSS
 2015- 2029 (28.80/10.90)	SSP.NSSPVPSPGSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.70|      25|      27|      36|      60|      11
---------------------------------------------------------------------------
   36-   60 (48.84/28.84)	FIRCLQANLLCVWRRDVKPDCKELW
   62-   86 (47.86/28.11)	FWWGDEPNLVDVIHRELHMVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.38|      20|      28|    1105|    1131|      12
---------------------------------------------------------------------------
 1105- 1124 (40.85/34.59)	CICACNMNIK.GADVGLYIPD
 1135- 1155 (34.53/14.05)	CGFSAIMNRKlGYNSGLFIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.40|       9|      17|    1164|    1173|      13
---------------------------------------------------------------------------
 1164- 1173 (11.99/ 9.85)	SDIGQAAeRR
 1183- 1191 (17.41/ 9.27)	SQMGEGA.RR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.85|      28|     477|    1474|    1506|      19
---------------------------------------------------------------------------
 1474- 1506 (42.65/39.82)	LATLQlDSS...LLLPPKYHT..PAPASqtqtVPGNTG
 1952- 1984 (42.20/24.64)	LNTPQ.DAScthILVFPTSATiqVAPAN....YPNEDG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01791 with Med13 domain of Kingdom Metazoa
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