<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01790

Description Mediator of RNA polymerase II transcription subunit 12-like (Fragment)
SequenceQDELTAVNVKQGFSNQPAFSGDEHGSARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQETAKDNYWLVTARSQSAIHNWFTDLAGNKPLTILAKKVPILSKKEDVFAYLAKYSVPLLRAAWLIKMTCAYYAAISEAKIKKRQATDPNIEWTQIITRYLREQLAKVAEFYHATFGQGNSSVVMPQEMEQALKQWEYNEKLSFYMFQEGMLERHEYLTWILDVLEKIRPTDDDLLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLGDGPNLVAAHSPHMIIGPNNPPLAAPSPTAPGPVVSPVQLACSDFLSCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKNINPGSPLDLLQVAPSSLPMPGGNSAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVMLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLTSSSLPIFQNVLLRFLDTQAPSLSDPNSDHEKTEFVNLVLLFSEFIRHDVFSHDAYMCTLISRGDLSITATTRPRSPNGETADEPYSKDHDVKLEDHSIMEHMGIDSGTTNIFDDVDKSDFKADFGSEFPVVTSEKSVKRERLRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQEAFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNLEQAAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAGRINDIANLCAELTACCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGSGKSFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSSSVNSLKSEDFTMRGLLDELNEDELWGSSHTLKSCGKAVSIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIKECNEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGPEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHMHPKPKPRSYYLEPLPLPPEEEEEEPTTPVSQEPERKSAELSDQGKHTTDDEKKTKGRKRKSKSSSRADVS
Length1769
PositionKinase
OrganismStruthio camelus australis
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Palaeognathae> Struthioniformes> Struthionidae> Struthio.
Aromaticity0.07
Grand average of hydropathy-0.319
Instability index50.21
Isoelectric point6.15
Molecular weight198076.57
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01790
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.05|      34|     149|     504|     578|       1
---------------------------------------------------------------------------
  515-  552 (49.07/84.67)	SEVLdekESISS.ASLTSSSLPIFQNVLLRFlDTQAPSL
  789-  823 (57.98/16.52)	SNVL...EQITSfASGTSYHLPLAHHIQLIF.DLMEPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     392.86|     118|     150|    1029|    1178|       2
---------------------------------------------------------------------------
  850-  907 (52.80/18.93)	...............SSSLAGSYTTGL..CVCIVAVLrRYHACL..ILNLEQAAQVFeGLCGVVKH.VVNPS....ECSSPE................................................................................................
 1029- 1155 (190.18/169.64)	SEWL...GVVKALccSSNHVWGFNDLL..CSVDVSDL.SFHDSLATFIAILIARQCF.SLEDVVQH.VALPSLLaaACGDPDA...............................EPGARMTCRLLLHL....FRTPQV........CLFPQGSGkSFPGIRSSCDrhllAAAHNSIEV
 1183- 1345 (149.88/82.36)	SEDFtmrGLLDEL..NEDELWGSSHTLksCGKAVSIE.T..ASLSEYARYVLRTIC..QQEWVGEHcLKEPERL...CTDKDLildpvlsnkqaqkllqlicyphgikecnegdNPQRQHIKRILQNLdqwtLRQSWLelqlmikqCMKEPGSG.SVAEMNSLLD....NIAKATIEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.95|      34|    1322|     363|     398|       4
---------------------------------------------------------------------------
  363-  398 (55.53/40.51)	SPLDLLQVAPSslPMPGGNSAFNQ.QVRAKIYEVEQQ
 1657- 1691 (61.41/38.93)	SPWDLFEGHKN..PAPLSWAWFGTvRVDRKVIKYEEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.18|      14|      33|     653|     666|       6
---------------------------------------------------------------------------
  653-  666 (24.24/15.26)	DFGSEFPVVTSEKS
  688-  701 (25.93/16.89)	QYATHFPIPLDESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.19|      15|     678|     733|     773|       7
---------------------------------------------------------------------------
  714-  728 (26.06/26.62)	GVGKERDEARHQLKK
  746-  760 (26.13/25.50)	GVGDEGQKARKNKQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.72|      17|      29|    1432|    1448|       8
---------------------------------------------------------------------------
 1432- 1448 (27.75/17.87)	KERDRQKQKSMSLLSQQ
 1459- 1475 (27.97/18.08)	KGQDEQREGLLTSLQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.94|      18|      29|     979|     997|      10
---------------------------------------------------------------------------
  979-  997 (27.53/18.96)	GKIlSD..NAANRYSFVCNAL
 1008- 1027 (28.41/15.06)	GRI.NDiaNLCAELTACCTVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.18|      33|     320|     232|     266|      14
---------------------------------------------------------------------------
  232-  266 (50.19/50.57)	PTDDDLLKLLLPLMLQYSeEFVQSAYLSRRlAYFC
  555-  587 (60.99/49.48)	PNSDHEKTEFVNLVLLFS.EFIRHDVFSHD.AYMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.88|      23|      23|    1492|    1514|      15
---------------------------------------------------------------------------
 1492- 1514 (39.67/27.42)	V.KARQMMHE.ALQLRLNLVGGMFD
 1516- 1540 (29.21/18.11)	VqRSTQWTTDwALLLLQIITSGTVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.90|      27|     623|     323|     352|      20
---------------------------------------------------------------------------
  323-  352 (47.36/32.81)	PQHRPLVYGLSCMLQTVTlccPSALVWNYS
  949-  976 (47.54/31.37)	PSNSNLLWDPEFMLDFIE..nPSAHSINYS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01790 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RSYYLEPLPLPPEEEEEEPTTPVSQEPERKSAELSDQGKHTTDDEKKTKGRKRKSKSSSRADVS
1706
1769










Molecular Recognition Features






MoRF SequenceStartStop




1) PRSYYLEPLPLPPEEEEEEPTTPVSQEPERKSAELSDQGKHTTDDEKKTKGRKRKSKS
1705
1762