<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01781

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYSCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDESDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNVNDNSFVETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLHGVDQMTLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANYASHPVGNLSKHKLFIKLTRLPQYYIVVEMFDVPGNPTELEYKYHFLSVSYAEGDDSPATALLLQQFKPNIEELVLDAKSGKQIKSGVKRKLSGDPCSTEPKKPKRSGEMCAFNKVLAHIVAMCDTNMPFIGLRMELSNMDIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPNHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSILQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVLLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQQPFAKQAGASAAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTSMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTAVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPG
Length1363
PositionTail
OrganismStruthio camelus australis
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Palaeognathae> Struthioniformes> Struthionidae> Struthio.
Aromaticity0.07
Grand average of hydropathy-0.213
Instability index54.10
Isoelectric point8.92
Molecular weight151551.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01781
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      94.14|      13|      16|    1034|    1046|       1
---------------------------------------------------------------------------
 1034- 1046 (29.07/12.35)	SPSQR.AGNWPGSP
 1052- 1065 (20.88/ 6.73)	SPAARmPGMSPANP
 1075- 1087 (20.04/ 6.16)	SHSPR.AGTSSQTM
 1276- 1288 (24.15/ 8.98)	PPSAP.PIAPPGTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.41|      25|     283|     812|     840|       2
---------------------------------------------------------------------------
  814-  838 (45.84/24.86)	PTVPMLGLT..QRTNTAYQCFSILPQS
 1002- 1028 (42.57/19.59)	PSPSSLGITmgQTANFASPHGTIDPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     253.66|      88|     474|     185|     283|       6
---------------------------------------------------------------------------
    6-   53 (47.21/21.57)	DMERKIEIVQFASRTRQLFVRLLALV..KWANNAgKVE.....KCAMISS.FlDQ..Q............................................................................................................................................................................................
  193-  218 (14.81/10.98)	.............................................................................ailfvdtadrlaslardalvharlpsfaipyaidvlttgsyprlptcirdkiippdpitksekqttlhqlnqilrhrlvttdlppqlanltvangrvkfrvegefeatltvmgddpdipwrllkleilvedketgdgraLVHSMQINFIHQ....LVQSRLFADEKPLQ
  219-  283 (86.45/56.84)	DMYSCLHSFCLALQLEVLHSQTLMLIreRWGDLV.QVErYHAGKCLSLSV.W.NQ..Q.......VLGRKTGTASVH.........................................................................................................................................................................
  717-  808 (105.19/61.67)	DIPNHLNIFS...EVRVYNYRKLIL...........C..YGTTKGSSISIqW.NSilQkfhislgTVGPNSGCSNCH.........................................................................................................................................ntILHQLQEMFNKTpnvvLLLQVLFDTQAPLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.31|      31|     239|    1094|    1126|       7
---------------------------------------------------------------------------
 1094- 1126 (50.84/34.98)	PRKLPQRSWAASIPTILTHSALNilLLPSPTPG
 1141- 1171 (52.48/30.42)	ERFLGSVIMRRHLQRIIQQETLQ..LINSNEPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.68|      40|     241|     352|     397|       8
---------------------------------------------------------------------------
  352-  397 (61.04/51.71)	NVNDNSFVEtALPTLVIPilePC.GRSECLHVFVD..LHSGMFQlmLHG
  600-  642 (63.64/36.56)	QVEGDGFSH.AIRLLKIP...PCkGVNEETQKALDrsLLDCTFR..LQG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01781 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQQPFAKQAGASAAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTSMPPPRKLPQRSWA
898
1103










Molecular Recognition Features






MoRF SequenceStartStop




1) ILKRFAEL
1350
1357