<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01779
Description |
Mediator of RNA polymerase II transcription subunit 1 (Fragment) |
Sequence | ISTNDLMEQLRLKYQQKTWAETLKLVHFCMDKPLRQPVSNAPDGPFRSCLEKIQRTLNAKSLFSMMNRLESLSKQKGLNAHVSPTGTTCYITSNMFYIEVQLEKDGEVVDVKLAHLGEAPVVCDDLVQHLRMKNYDAFGNILEDLSNLYQTPGNSEMKAKGYLALQALEKDIYSMSLLDRVQDVNRVTEVLHGKVGHLVPRTGGTPMSIEFYISPYQALEAELNPGSQVCGTKAIVIVEGTDTLHRLSLSPLLVDSQTGEDGNPTFLPLTDELSMEFSAFFVMKFHQPIPMSSSSIEEIQRLTGMLSLFLRLRIQITGLKLAPLYELIVQSTLKEKCSEDLSTHQSCFFVSLPDCPKHCYFINKGSGRSDLAGALVSKIPFSHPKCVPGVIEILRHQVARNTLISSCVSERHINEDDSELLYFEVVPHKNSSFSVFFLHPVKENLACVAIDVIASREVRCHLHLNPQDPTLNSSDDFIARALMRCMSVPLLMRAIFRNAAKVKANS |
Length | 506 |
Position | Middle |
Organism | Dryobates pubescens (Downy woodpecker) (Picoides pubescens) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda>
Coelurosauria> Aves> Neognathae> Piciformes> Picidae> Picoides.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.098 |
Instability index | 44.95 |
Isoelectric point | 6.40 |
Molecular weight | 56647.81 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP01779
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.92| 12| 65| 271| 282| 1
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271- 282 (22.16/15.58) DELSMEFSAFFV
339- 350 (23.76/17.27) EDLSTHQSCFFV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 147.37| 46| 48| 131| 176| 8
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131- 176 (77.86/53.41) RMKNYDAFGNILE.DLSNLYQTPGNSEMKAKGYLA.LQALEKDIYSMS
180- 227 (69.51/46.95) RVQDVNRVTEVLHgKVGHLVPRTGGTPMSIEFYISpYQALEAELNPGS
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