<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01776

Description Mediator of RNA polymerase II transcription subunit 12-like (Fragment)
SequenceQDELTAVNVKQGFSNQPAFSGDEHGSARNVVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGSKPLTLLAKKVPILSKKEDVFAYLAKYSVPLLRAAWLIKMTSAYYAAVSEAKIKKRQASDPNMEWTQIVTKYLREQLAKVAEFYHLTASQGSSSTVMPQEMEQALKQWEYNEKLSFYMFQEGMLERHEYLTWILDVLEKIRPTDDDLLKLLLPLMLQYSEEFVQSAYLARRLAYFCARRLALLLGDAPSLLAAHPPHLILGAGNPALAAPSPTAPGAAVSPLQLACSDFLSCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENRSMNPGSPLDLLHVAPSGLPMPGGNSAFNQQVRAKISEEEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNRDTQEGAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGEAEVLDEKESLSSASLTGSSLPVFQNVLLRFLDTQAPSLSDPNSDHEKTEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSLTAAPRPHSPNGDVVEEHYSKDHDVKLEDHTIMEHMGLDSGATSIFDDVDKSDFKAEFGSEFPVVASEKSVKRERLREVIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMVLLYGVGKERDEARHQLKKITKDILKILNKKSTTELGVGDEGQKARKIKQEAFPSLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQASRALPFALLQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNAEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNLQPSNSNLLWDPEFMLDFLENPSTHSLNYSVLGKILSENAANRYSFVCNALMSVCMGHQDAARINDIANLCAELTACCTLLSAEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFVAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGAGKLFPGIRSSCDRHLLAAAHNNMEVGAVFAVLKAILMLGDAEIGSNSVGSSKGEDFPVRGLLGELHEEEMWGSSQPLKPCGKAVPIESASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIKECSEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMLKQCTKEPGSGAVAEMNSLLDNIAKATIEVFQHSAALNNNSSNSGIGLCSPNSLGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQVKQAQSHQHPVCQQAELQMMHEALQLRLNLVGGMFDTVQRSSQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGPEENKRAYMNLVKKLKKELGDKRSESIDRVRQLLPLPKQTCDIIACEPMGSLIDTKGNKIAGFDSIDKKQAGLQVSTKQKVSPWDLVEGHKTPAPLSWGWFGTVRVDRKVIKYEEQQHLLLYHTHPKPKPRSYYLEPLPLPPEEEEEEEEPTTPVSQEPERKLGELSDQGKHTADDEKKAKGRKRKSKASSRADVSS
Length1782
PositionKinase
OrganismDryobates pubescens (Downy woodpecker) (Picoides pubescens)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Piciformes> Picidae> Picoides.
Aromaticity0.07
Grand average of hydropathy-0.279
Instability index49.94
Isoelectric point6.19
Molecular weight198146.87
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01776
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     226.13|      72|     147|     504|     578|       1
---------------------------------------------------------------------------
  504-  578 (111.01/90.09)	QAEIEAERCGEAEVLDEKESLSSASLTGSSLPVFQNvLLRFLD..TQAPSLSDPNSDHEKTEfvNLVLLFS.....EFTRHD
  647-  725 (115.13/81.83)	KSDFKAEFGSEFPVVASEKSVKRERLREVIFPSNYD.LLRHLQyaTHFPIPLDESSSHECNQ..RMVLLYGvgkerDEARHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.79|      29|     147|     886|     915|       2
---------------------------------------------------------------------------
  886-  915 (48.50/33.95)	CLILNAEQTAqVFEGLCGVVKHV..VNPSECS
 1035- 1065 (49.29/29.84)	CTLLSAEWLG.VVKALCCSSNHVwgFNDLLCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.89|      47|     149|    1076|    1189|       3
---------------------------------------------------------------------------
  278-  325 (83.85/26.18)	PSLLAA..HPPHLILGAGNPA.LAAPSPTAPGAAVSPlQLACSDF....LSCPQH
 1102- 1155 (75.04/129.54)	PSLLAAacGDPDAEPGARMTCrLLLHLFRTPQVCLFP.QGAGKLFpgirSSCDRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.08|      39|     314|    1416|    1454|       7
---------------------------------------------------------------------------
 1416- 1454 (64.15/39.03)	PTS.VQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMS
 1736- 1775 (59.93/35.97)	PTTpVSQEPERKLGELSDQGKHTADDEKKAKGRKRKSKAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.31|      25|     150|     775|     820|       9
---------------------------------------------------------------------------
  793-  818 (39.75/56.60)	EQITSFASGTSYHLPLAhHIQLIFDL
  826-  850 (41.56/11.88)	NGLIDFAIQASRALPFA.LLQLLNEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01776 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PRSYYLEPLPLPPEEEEEEEEPTTPVSQEPERKLGELSDQGKHTADDEKKAKGRKRKSKASSRADVSS
2) VLKAAGEELEKGQHLGSSSKKERDRQKQKS
1715
1423
1782
1452










Molecular Recognition Features






MoRF SequenceStartStop




1) KPRSYYLEPLPLPPEEEEEEEEPTTPVSQEPERKLGELSDQGKHTADDEKKAKGRKRKSKASSRADV
1714
1780