<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01765

Description Mediator of RNA polymerase II transcription subunit 12 (Fragment)
SequenceQDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINNWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFIEWTQIITKYLSEQLQKIAEFYRQLPGQGCGSPSGPMPQEVEQALKQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRSGEDEFLKMLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLAMQLDGAGGHPPHILSAQAGNALPSTPTPQPAAVNPPPSPFSDLLLCPQHRPVVYGLSCILQSIILCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPGGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGLGPTKDSHEISPDDDAVVALLCEWAVSYKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSISSGSLSAASAPVFQDVLMQFLDTQAPMLTDPGKENEKVEFFNLVLLFCELIRHDVFSHNIYMCTLISRGDLALDAHGPRPPSPFDDPAEEHDRKEAEGSSGIKLEDTGLSEPMDIDHNSSMLFDDMEKTDFSMFSPPMHCESKASPSPEKTDPEKEAKPLLKDKSVEGMLASLYDQPRHIQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHTIKKITKDILKVLNRKSTAETGSLMLFSDPPLVGGEEGQKRKKSKPEAFPTAEDIFAKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHSCLILNQDQMAQVFEGLCGVVKNGINRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEPEFMIDTIENPSAHNFTYTNLGKSLNENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDASANVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHPGGVDDLMDDELGTRKAGGRVVTVETASLDIYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSTQAQRLMQLICYPHRLLDNEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTASNEMNSLLENIAKATIEVFQQSAETSSASSAGNGVNNISSSASATPASNKSKPILSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQYQDDCKAKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTVRVDRKVSRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVTLEPEKKAAEPAKADKTSSNPATSTEERKKKQSKTKKRNQSASKTEDFVLGPSRGVSYGVGMPTDLLHHQSGSTMSRLAYGQSPVTSIYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPYSGVLPPGMGSMMGIDPSYKPAVYRQQPPVSQGQILRQQLQAKLQGQGIMGQQPVRQMAPTPSYGALQPSQGYTPYVSHIGIQQHPSQSSTIVPPTYSGQPYQNSHPSSTPAMVDPVRQMQQRPSGYVHQQAPGYGHTLGSTQRFPHQSIQQAPMMSGMNHLGPQGVSSGIRPSQILPDQQQQQYLRQQQQMLRLCSHSALSQEQQELANVTDTSLTFPSLLSWQQQQQQQQQQQQQQPQPQPPQPQQQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQTQQNNNPFGRY
Length2132
PositionKinase
OrganismDryobates pubescens (Downy woodpecker) (Picoides pubescens)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Piciformes> Picidae> Picoides.
Aromaticity0.07
Grand average of hydropathy-0.435
Instability index53.73
Isoelectric point6.54
Molecular weight237524.16
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01765
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.54|      14|      17|    1627|    1643|       2
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 1627- 1643 (16.85/18.14)	KIAGFDsIFkkEGLQVS
 1647- 1660 (28.68/16.35)	KISPWD.LF..EGLKHS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     206.13|      30|      30|    1865|    1894|       3
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 1824- 1854 (23.88/ 6.83)	YRPvrmplgklvQSRPPY.S......................G.VLPP.........GMGsMMG
 1855- 1891 (45.03/20.26)	IDP..sykpavyRQQPPV.S.....................QGQILRQQLQA.KLQ.GQG.IMG
 1892- 1914 (22.82/ 6.16)	QQP........vRQMAPTpS.....................YGA.L....QP.S.Q.GYT....
 1915- 1944 (26.19/ 8.30)	..P...yvshigIQQHP..S.....................QSSTI...VPP.TYS.GQP.YQN
 2011- 2042 (31.42/11.62)	IRP........sQILPDQ.Q.....................QQQYLRQQQQMlRLC.SHS.ALS
 2045- 2076 (30.25/10.88)	QQE......lanVTDTSL.T.....................FPSLLSWQQQQ.QQQ.QQQ..QQ
 2077- 2125 (26.54/ 8.52)	QQP.........QPQP....pqpqqqpqfqrqglqqtqqqqQTAALVRQLQQ.QLSnTQT.QQN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.48|      32|     107|     160|     191|       4
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  160-  191 (61.23/31.55)	TKYLSEQLQKIAEFYRQ.LPGQ.GCGSPSGPMPQ
  269-  302 (51.24/25.16)	TRRLAMQLDGAGGHPPHiLSAQaGNALPSTPTPQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.43|      33|     107|     940|     974|       5
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  896-  930 (50.34/29.83)	YHSCLILnQDQMAQVFEGLCGVVKNGINrSDGSSA
  942-  974 (61.10/38.07)	YTSCSHL.KSKFGELFSDFCSKVKNTIY.CNVEPS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     155.08|      37|     113|     647|     696|       6
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  523-  554 (29.94/ 7.75)	..GSLSAASAPvfqdVLMQFLDTQAPMLTDPGKE.......
  647-  683 (65.63/47.05)	EKTDFSMFSPP....MHCESKASPSPEKTDPEKEAKPLLKD
  757-  791 (59.51/23.35)	ETGSLMLFSDP....PLVGGEEGQKRKKSKP..EAFPTAED
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.23|      23|     108|    1591|    1617|       7
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 1591- 1617 (36.81/30.57)	QSDSLEKvrqlLPLPKQTRD...VITCEPQ
 1698- 1723 (38.42/22.07)	RSYYLEP....LPLPPEEEEpptPVTLEPE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.12|       9|     231|    1768|    1777|       8
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 1768- 1777 (15.21/12.24)	LGPsRGVSYG
 2002- 2010 (18.91/ 9.95)	LGP.QGVSSG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.44|      35|     289|     305|     341|       9
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  305-  341 (67.19/41.64)	AVNP.PPSPFSDLllCPQH.RPVVYGLSCI.LQSIILCCP
  595-  632 (54.25/27.99)	AHGPrPPSPFDDP..AEEHdRKEAEGSSGIkLEDTGLSEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.49|      15|      15|    1361|    1375|      10
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 1361- 1375 (25.52/18.28)	SASSAGNGVNNISSS
 1377- 1391 (25.96/18.75)	SATPASNKSKPILSS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.30|      18|      18|    1185|    1202|      11
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 1185- 1202 (29.25/23.95)	GAVFAVLKAVFVLGDAEL
 1204- 1221 (34.05/29.48)	GSGFSHPGGVDDLMDDEL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.10|      16|      22|    1961|    1977|      12
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 1961- 1977 (28.83/25.61)	QQRPSGYVhQQAP...GYGH
 1983- 2001 (28.27/18.23)	QRFPHQSI.QQAPmmsGMNH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.96|      11|      22|    1038|    1048|      14
---------------------------------------------------------------------------
 1038- 1048 (21.19/13.93)	AILCAELTGYC
 1061- 1071 (22.77/15.65)	ALCCSSNNGTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.58|      21|      23|    1515|    1537|      15
---------------------------------------------------------------------------
 1515- 1537 (29.71/30.67)	QQTTewAVL.LLDIISSGTV..DMQS
 1540- 1563 (24.87/15.82)	ELFT..TVLdMLSVLINGTLaaDMSS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.72|      15|      17|    1731|    1745|      25
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 1731- 1745 (24.89/17.30)	KADKTSSNP..ATSTEE
 1749- 1765 (19.82/11.98)	KQSKTKKRNqsASKTED
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01765 with Med12 domain of Kingdom Metazoa
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