<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01761

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSCFVPNGASLEDCHSNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRELWIFWWGDDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEISQHQPVYLLSEEHLTLAQQSNSPFQVILSPFGLNGTLTGQSFKLSDSSTKKLIGEWKQFYPVTSNLKEGSEEKQEEMDWEDDSLAAVEVLVAGVRMVYPACFVLVPQTDIPAPSTVGASHCSTTCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDAQSAQKWVKFSSVSDGFISDSTSHHGGKIPRKLANQVVDRVWQECNMNRAQNKRKYSATSNGLCDEETADKVASWDFVEATQRTNCNCSRHKNLKPRNSGQQGQAPPVGPQQQAAPKHKTNEKQDKGDKPQKRPLTPFHHRVSLSDDVAMEADSASQRLVMAAPDSQVRFSNIRTNDVAKTPQMHSAEMANSPQPPPLSPHPCDVVDEGVAKAPSTPQSQHFYQMPTPDPLVPTKAMEDRLDGLSQPFPAQFPEVIEPTMYVGTAVNLEEDEADTTWKYYKVPKKKDVEFLPPQLPNDKLRDDPVIPAGQENVTSVTELMVQCRKPLKVSDELVQQYQSKNQYLAAVATEADQEPEIDPYAFVDGDVEFLFPDSKKDRQNIEREAGKKHKAEDGTSSVTVLSHEGEDAMSLFSPSVKQDAQRIAAHARTASTSLFHETDLVVSYTDLDNLFNSDEDELTPGSKRTVNGADDKSNCKEAKAGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTLGGTVLEGNSSSVGAQFRIEVDEGFCSPKPAEIKDYSYVYKPENCQALVGCSMFAPLKTLPSQCLPPIKLPEECIYRQSWAVGKLDLLPPGPAMPFIKDGDGSTMDQEYGPAYTPQTHTPFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNSSGLFLEDELDILGRNTECGKEAEKRFEALRATSIEHGSGGLKEPEKLPDELILLLQDQCTNLFSPFGAADQDSIPKVGAVSNPVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKTTCLHHWSKRNVVDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDVAYVVVCPENEALLNGAKSFFRDLTAIYESCRLGQHRPICKLLPDGIMRVGPTASKKLSEKLVTEWFSQTANANNEAFSKLKLYAQVCRYELGPYLASQPLDNSLLSQTNLVPPSSQLASALPPVTANAGNPNTPSSAPAAPTSSTVTVTSNSAMSSAATTVNSTLTTTAPSSSSANMGSGIPTSKPSSFPSFSSMNNTTSASLPTQAATVQNGQTGGQQQQPTLQTAGMSGDATSAPAQPHPEVSESTMDRDKVGVPTDGDSHAITYPPAIVVYIIDPFTYEKKDENSSSSSLWTLGLLRCFLEMVQVLPPNIKNIISVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWLLASCTDLYGEQLETCIINIDVPNRARRKKGSARRLGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFIIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASSTYTTENLDLAFNTNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDMGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Length2179
PositionMiddle
OrganismDryobates pubescens (Downy woodpecker) (Picoides pubescens)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Piciformes> Picidae> Picoides.
Aromaticity0.07
Grand average of hydropathy-0.401
Instability index51.15
Isoelectric point5.40
Molecular weight239487.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01761
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     146.11|      32|      40|     983|    1014|       1
---------------------------------------------------------------------------
  564-  587 (26.42/ 6.59)	PtPDPLVPT.KAMEDRLDGL.SQP.FP.................................
  989- 1026 (56.49/22.63)	P.PSSAPPS.NGGAGILPSP.STPRFPTPrtprtpR...................TPRGA
 1028- 1055 (28.93/ 7.93)	G.PASAQGSvKYENSDLYSPaSTPSTCRP...............................
 1495- 1541 (34.27/10.78)	P.PVTA....NAGNPNTPS..SAPAAPTS......StvtvtsnsamssaattvnsTLTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.41|      35|      40|    1118|    1157|       2
---------------------------------------------------------------------------
 1118- 1157 (52.72/47.82)	QEAQYRctcgFSAVMNRKFGNSSGLF.....LEDELdILGRNTEC
 1159- 1198 (54.69/32.76)	KEAEKR....FEALRATSIEHGSGGLkepekLPDEL.ILLLQDQC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     672.47|     215|     265|      46|     300|       3
---------------------------------------------------------------------------
   46-  300 (339.99/297.14)	PVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRelWI.FWWGDDPNFAD.LIHH......DLSEE.EDGVWenglsyecrtllfkavhnllERCLMN.....RNFV.............RIGKW.FVKPyekdekpinkSEHLSCSFTffLHGDSNVCTSVEISQHQPV...YLLSEEHLTLAQQ..SNSPFQVILSPFGLNGTLTGQSFKLSDSSTKKLIGEWKQFYPVTSNLKEGSEEKQEEMDWEDDSLAAVEVLVAGvrmvYPaCFVlVPQTDIPAPSTVGASH
  312-  559 (332.48/213.08)	PASTRDPAMSSVTLTPPTSPEEVQTVDAQSAQK..WVkFSSVSDGFISDsTSHHggkiprKLANQvVDRVW....................QECNMNraqnkRKYSatsnglcdeetadKVASWdFVEA..........TQRTNCNCS..RHKNLKPRNSGQQGQAPPVgpqQQAAPKHKTNEKQdkGDKPQKRPLTPFHHRVSLSDDVAMEADSASQRLVMAAPDSQVRFSNIRTNDVAKTPQMHSAEMANSPQPPPLSP....HP.CDV.VDEGVAKAPSTPQSQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.00|      12|      40|     708|     719|       4
---------------------------------------------------------------------------
  708-  719 (23.02/13.73)	LF.PDSKKDRQNI
  749-  761 (17.98/ 8.95)	LFsPSVKQDAQRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.19|      16|      18|    1543|    1559|       5
---------------------------------------------------------------------------
 1543- 1559 (25.35/20.80)	PSSSSANMgSGIPTSKP
 1595- 1610 (29.84/19.21)	PTLQTAGM.SGDATSAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.52|      12|      40|     848|     859|       7
---------------------------------------------------------------------------
  848-  859 (25.08/13.91)	GF.SPMNMNNKEY
  889-  901 (19.44/ 9.03)	GFcSPKPAEIKDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.45|      15|      41|    1423|    1437|       8
---------------------------------------------------------------------------
 1423- 1437 (24.67/13.14)	GP.TASKKLSEKLVTE
 1465- 1480 (21.78/10.64)	GPyLASQPLDNSLLSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.47|      38|    1064|     593|     706|      11
---------------------------------------------------------------------------
  657-  701 (52.79/123.71)	LMVQCRKPLKVSDELVQQyQSknqylAAVAtEADQEPEIDPYAFV
  925-  962 (72.68/19.31)	LPSQCLPPIKLPEECIYR.QS.....WAVG.KLDLLPPGPAMPFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.15|      31|     534|    1080|    1116|      12
---------------------------------------------------------------------------
 1080- 1116 (51.00/59.26)	SESVMNLFK...DCNFDSCCIcvcnmNIKGADVgVYIPDP
 1618- 1651 (54.15/39.66)	SESTMDRDKvgvPTDGDSHAI.....TYPPAIV.VYIIDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.07|      22|     645|    1438|    1459|      13
---------------------------------------------------------------------------
 1438- 1459 (39.50/28.51)	WF.SQTANANNEA..FSKLKLYAQV
 2085- 2109 (34.57/23.81)	WFwSACPQAQNQCplFLKASLHLHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.53|      23|     535|    1292|    1314|      15
---------------------------------------------------------------------------
 1292- 1314 (42.26/21.89)	VLQDAIQKKRTVRSWGVQGPLTW
 1829- 1851 (42.26/21.89)	VPNRARRKKGSARRLGLQKLWEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.58|      28|     420|    1344|    1379|      16
---------------------------------------------------------------------------
  625-  654 (46.17/20.97)	DVEFL...PPQLPN.DKLRDDPVipAGQENVTSV
 1345- 1376 (43.41/37.09)	DYDFLvlsPFALPYwERLMLEPY..GSQRDVAYV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01761 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSKKDRQNIEREAGKKHKAEDGTSSVTVLSHE
2) GPAMPFIKDGDGSTMDQEYGPAYTPQTHTPFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
3) GSPVHSPGSHYPHGGDMGKGQGTDRLLSTESH
4) NCNCSRHKNLKPRNSGQQGQAPPVGPQQQAAPKHKTNEKQDKGDKPQKRPLTPFHHRVSLSDDVAMEADSASQRLVMAAPDSQVRFSNIRTNDVAKTPQMHSAEMANSPQPPPLSPHPCDVVDEGVAKAPSTPQSQHFYQMPTPDPLVPTKAMEDRLDGLSQPFP
5) SQLASALPPVTANAGNPNTPSSAPAAPTSSTVTVTSNSAMSSAATTVNSTLTTTAPSSSSANMGSGIPTSKPSSFPSFSSMNNTTSASLPTQAATVQNGQTGGQQQQPTLQTAGMSGDATSAPAQPHPEVSESTMDRDKVGVPTDGD
711
956
2026
423
1488
742
1041
2057
587
1634










Molecular Recognition Features






MoRF SequenceStartStop




NANANA