<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01755

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSCFVPNGASLEDCHSNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRELWIFWWGDDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEISQHQPVYLLSEEHLTLAQQSNSPFQVILSPFGLNGTLTGQSFKLSDSSTKKLIGEWKQFYPVTSNLKEGFEENQEEVDWEDDSLAAVEVLVAGVRMVYPACFVLVPQTDIPAPSTVGASHCSTTCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDAQSAQKWVKFSSVSDGFISDSTSHHGGKIPRKLANQVVDRVWQECNMNRAQNKRKYSATSNGLCDEETPDKVAAWDFVEATQRTNCNCSRHKNLKPRNSGQQGQAPPVGQQQQAAPKHKTNEKQDKGDKPQKRPLTPFHHRVSISDDVAMEADSASQRLVMTAPDGQVRFSNIRTNDVAKTPQMHNAEMANSPQPPPLSPHPCDVVDEGVTKAPSTPQSQHFYQMPTPDPLVPTKTIDDRLDGLSQPFPAQFPEVIEPTMYVGTAVNLEEDEADTTWKYYKVPKKKDVEFLPPQLPNDKLRDDPVIPAGQENVTSVTELMVQCRKPLKVSDELVQQYQSKNQYLAAVATEADQEPEIDPYAFVDGDVEFLFPDSKKDRQNIERETGKKHKGEDGTSSVTVLSHEGEDAMSLFSPSVKQDAQRIAAHARTASTSLFHETDLVVSYTDLDNLFNSDEDELTPGSKRTVNGADDKSNCKEAKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTLGGTVLEGNSSTVGSQFRIEVDEGFCSPKPAEIKDYSYVYKPENCQALVGCSMFAPLKTLPSQCLPPIKLPEECIYRQSWTVGKLDLLPPGPAMPFIKDGDGSTMDQEYGPAYTPQTHTPFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDILGRNTECGKEAEKRFEALRATSVEHGSGGLKEPEKLPDELILLLQDQCTNLFSPFGAADQDSIPKAGAVSNLVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKTTCLHHWSKRNVVDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDVAYVVVCPENEALLNGAKSFFRDLTAIYESCRLGQHRPICKLLPDGIMRVGPTASKKLSEKLVTEWFSQTANANNEAFSKLKLYAQVCRYELGPYLASQPLDNSLLSQTNLVPPSSQPASALPPVTANVGNPNTPSSAPTAPASSSMTATSNGAMSSAATTANSTLTTTAPSSSSASIGSGIPTSKPTSFPPFSSMNNTTSASLPTQAAAVQNGQTGGQQQQSTLQTAGMSGDATSVPAQPHPEVSESTMDRDKVGVPTDGDSHAITYPPAIVVYIIDPFTYEKKDENNSSSSLWTLGLLRCFLEMVQALPPNIKNIISVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWLLASCTDLYGEQLETCIINIDVPNRARRKKGSARRLGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFIIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASSTYTTENLDLAFNTNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDMGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Length2179
PositionMiddle
OrganismOpisthocomus hoazin (Hoatzin) (Phasianus hoazin)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Opisthocomiformes> Opisthocomidae> Opisthocomus.
Aromaticity0.07
Grand average of hydropathy-0.410
Instability index50.36
Isoelectric point5.38
Molecular weight239644.57
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01755
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     161.43|      46|      62|     466|     511|       1
---------------------------------------------------------------------------
  466-  493 (37.75/12.49)	....................................DK..PQKRP..LTPFHHRVSISDDVAMEADSA
  494-  554 (68.51/28.03)	SQRLV.MTAPDGQVRFSNIrtndvaktpqmhnaemaNS..PQPPP..LSP..HPCDVVDEGVTKAPST
  557-  611 (55.17/21.29)	SQHFYqMPTPDPLVPTKTI..........ddrldglSQpfPAQFPevIEPTMY...VGTAVNLEEDEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     288.60|      64|      68|     926|     990|       2
---------------------------------------------------------------------------
  926-  990 (116.04/62.31)	PSQCLPPIkLP.......EECIYR.QSWTVGKLDLLPPGPAMPFIKDGDGS....TMDQE.YG.................PAYTPQTHTPF.GMPP
  995- 1061 (102.33/50.89)	PSNSGAGI.LP.......SPSTPRfPTPRTPRTPRTPRGAGGPASAQGSVK....YENSDlYS.................PASTPSTCRPLnSVEP
 1486- 1570 (70.23/32.27)	PSSQPASA.LPpvtanvgNPNTPS.SAPTA......PASSSMTATSNGAMSsaatTANST...ltttapssssasigsgiPTSKPTSFPPFsSMNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.90|      44|      69|    1663|    1710|       3
---------------------------------------------------------------------------
 1663- 1710 (69.27/58.13)	SSSLWTLGLLRCFLEMVQAL.PPNIKNIISVQIVPcqYLLQPVKheDRQ
 1734- 1778 (75.64/48.75)	STNVKTLTGFGPGLAMETALkSPDRPECIRLYTPP..FILAPVK..DKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.51|      15|      71|    1121|    1137|       4
---------------------------------------------------------------------------
 1121- 1137 (27.06/21.30)	QYRCTCGFSAvmNRKFG
 1152- 1166 (23.32/11.17)	GRNTECGKEA..EKRFE
 1195- 1206 (23.13/11.02)	QDQCTNLFS.....PFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.00|      12|      40|     708|     719|       6
---------------------------------------------------------------------------
  708-  719 (23.02/15.12)	LF.PDSKKDRQNI
  749-  761 (17.98/ 9.89)	LFsPSVKQDAQRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.70|      17|      70|     836|     852|       7
---------------------------------------------------------------------------
  836-  852 (35.44/23.40)	YPTPPSLEQHIMG...FSPM
  903-  922 (27.26/15.88)	YVYKPENCQALVGcsmFAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.06|      12|      18|    1594|    1610|       9
---------------------------------------------------------------------------
 1594- 1610 (15.25/18.32)	QSTlqtagMSGDATSVP
 1619- 1630 (20.81/10.28)	EST.....MDRDKVGVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.61|      67|     263|      46|     134|      11
---------------------------------------------------------------------------
   46-  134 (108.65/110.42)	PVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRelWI.FWWGDDPNFAD.LIHH......DLSEE.EDGVWEnglsyECRtllfkavhnllerclMNR
  312-  387 (101.96/62.87)	PASTRDPAMSSVTLTPPTSPEEVQTVDAQSAQK..WVkFSSVSDGFISDsTSHHggkiprKLANQvVDRVWQ.....ECN...............MNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.46|      50|     646|    1401|    1474|      14
---------------------------------------------------------------------------
  192-  250 (70.59/38.66)	EHLTLAQqsNSPFQVILsPFGLNGTLTGQSFKLSDsstkKLIGEWkqFYPVTSNLKEGF
 1401- 1450 (90.87/106.92)	ESCRLGQ..HRPICKLL.PDGIMRVGPTASKKLSE....KLVTEW..FSQTANANNEAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.51|      11|      20|    1326|    1336|      20
---------------------------------------------------------------------------
 1326- 1336 (22.98/13.68)	YGTD...ESPEPLP
 1344- 1357 (17.52/ 8.12)	YDYDflvLSPFALP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01755 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSKKDRQNIERETGKKHKGEDGTSSVTVLSHE
2) GPAMPFIKDGDGSTMDQEYGPAYTPQTHTPFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
3) GSPVHSPGSHYPHGGDMGKGQGTDRLLSTESH
4) LSQTNLVPPSSQPASALPPVTANVGNPNTPSSAPTAPASSSMTATSNGAMSSAATTANSTLTTTAPSSSSASIGSGIPTSKPTSFPPFSSMNNTTSASLPTQAAAVQNGQTGGQQQQSTLQTAGMSGDATSVPAQPHPEVSESTMDRDKVGVPTDGD
5) NCNCSRHKNLKPRNSGQQGQAPPVGQQQQAAPKHKTNEKQDKGDKPQKRPLTPFHHRVSISDDVAMEADSASQRLVMTAPDGQVRFSNIRTNDVAKTPQMHNAEMANSPQPPPLSPHPCDVVDEGVTKAPSTPQSQHFYQMPTPDPLVPTKTIDDRLDGLSQPFP
711
956
2026
1478
423
742
1041
2057
1634
587










Molecular Recognition Features






MoRF SequenceStartStop




NANANA