<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01749

Description Mediator of RNA polymerase II transcription subunit 12-like (Fragment)
SequenceQDELTAVNVKQGFSNQPAFSGDEHGSARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGSKPLTLLAKKVPILSKKEDVFAYLAKYSVPLLRAAWLIKMTCAYYAAISEAKIKKRQATDPNIEWTQIITRYLREQLAKVAEFYHVTSSQGNSSVVMPQEMEQALKQWEYNEKLAFYMFQEGMLERHEYLTWILDVLEKIRPTDDDLLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDGPNLVAAHSPHMMIGPSNPPLAAASPTAPGPVVSPVQLACSDFLCCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKNVNPGSPLDLLQVAPSSLPMPGGNSAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESLSSASLTGSSLPVFQNVLLRFLDTQAPSLSDPSSDHEKTEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSITATTRPRSPNGEAVDERYSKDRDVKLEDHSIMEHMGIDSGTGSIFDDVDKSDFKADFGSEFPVVTSEKSVERPRLRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMILLYGVGKERDEARHQLKKITKDILKILNKKSTTEMGVGDEGQKARKTKQETFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLLDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNSEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNVLMNVCMGHQDAGRINDIANLCAELTACCTVLSTEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGTGKLFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSNNVNSLKSEDFHMRGLLDELNEDDIWGSSLKSCGKAVSIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIKECTEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCTKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQVKQARKHEHPSNWREDRYQDDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTEWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGPEENKRAYMNLVKKLKKELGDKRSDSIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHMHTKPKPRSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGELLDQGKLAADDEKKTKGRKRKSKSSSRADVSS
Length1776
PositionKinase
OrganismOpisthocomus hoazin (Hoatzin) (Phasianus hoazin)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Opisthocomiformes> Opisthocomidae> Opisthocomus.
Aromaticity0.07
Grand average of hydropathy-0.319
Instability index48.45
Isoelectric point6.27
Molecular weight198790.47
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01749
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.15|      56|     276|     515|     710|       1
---------------------------------------------------------------------------
  645-  710 (83.93/237.28)	VDKSDFKADFGSEFpvvTSEKSverpRLRELIF....PSNYDLLRHLQYATHFpipLDESSSHECNQRMI
  919-  978 (97.22/19.93)	VSCSHLRSKFGDLF...SSACS....KVKQTIYsnvqPSNSNLLWDPEFMLDF...IENPSAHSINYSML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      56.66|      16|      35|    1001|    1017|       2
---------------------------------------------------------------------------
  316-  333 (19.45/ 7.38)	C.................sdflCCP.QHRPLVYGLS..
 1001- 1016 (16.24/10.15)	......................CMGHQDAGRINDIAnL
 1017- 1052 (20.97/ 8.89)	CaeltacctvlstewlgvvkalCCSSNHVWGFNDL..L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.23|      30|     275|     515|     552|       3
---------------------------------------------------------------------------
  515-  544 (47.71/25.96)	SEVLDEKESLSSASLTGSSLPVFQNVLLRF
  789-  816 (45.13/23.73)	SNVLEQITSF..ASGTSYHLPLAHHIQLIF
  844-  872 (43.39/25.18)	AELLLKSSSLAGSYTTGLCVCIV.AVLRRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.81|      39|      39|    1262|    1300|       4
---------------------------------------------------------------------------
 1224- 1264 (48.93/27.04)	RYVLRTIC.QQ..EWVGEhCL.K..EPERLCTDKDL.I.LDPvlsnKQA
 1265- 1306 (63.92/37.64)	QKLLQLIC.YP..HGIKE.CT.EGDNPQRQHIKRILQN.LDQ.wtlRQS
 1307- 1336 (32.99/15.76)	WLELQLM........IKQ.CTkEPGSGSVAEMNSLLDN.I.........
 1437- 1480 (40.97/21.40)	QKSMSLLSqQPflSLVLT.CL.KGQDEQREGLLTSLQNqVNQ...vKQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.81|      33|     320|     232|     266|       7
---------------------------------------------------------------------------
  232-  266 (50.12/47.23)	PTDDDLLKLLLPLMLQYSeEFVQSAYLSRRlAYFC
  555-  587 (60.69/45.99)	PSSDHEKTEFVNLVLLFS.EFTRHDVFSHD.AYMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.88|      10|      25|     409|     418|       8
---------------------------------------------------------------------------
  409-  418 (20.90/13.34)	RWSFDKCQES
  436-  445 (19.98/12.38)	RHCFDRSDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.06|      11|      29|     714|     724|      14
---------------------------------------------------------------------------
  714-  724 (20.75/13.24)	GVGKERDEARH
  746-  756 (20.30/12.79)	GVGDEGQKARK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.13|      15|     189|     893|     907|      15
---------------------------------------------------------------------------
  893-  907 (27.34/15.59)	VVKHVV.NPS....ECSSPE
 1084- 1102 (22.35/11.28)	VVQHVA.LPSllaaACGDPD
 1113- 1128 (21.44/10.50)	LLLHLFrTPQ....VCLFPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01749 with Med12 domain of Kingdom Metazoa
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