<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01744

Description Mediator of RNA polymerase II transcription subunit 1 (Fragment)
SequenceETEKLNKMSTLLERLHTKYNQNRPWTETMKLVRQVMEKRVVMNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLSKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVILHENNVPRSLGMNVSVTVEGTMTMYKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQGCTGIPLFDTPPTFVPLYELITQFELSKEADPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSLSMKERHDSVGHGEDFSKVSQNPILTSLLQITGSVGSAIGSSPTPPHHTPPPVSSPAGNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGSKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPTTNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPTSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYASQALSTLGVQVLGADGGENKFKGSNQSDTVDFSIIAAASKALGSSDILEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSNMAGPGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGGSSSGQSKSSAQSVGKPGSSPITKHGLSSGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGSGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTGGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKNSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDSLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSMKPESWSKSPISADQSLSMTSSAILSAERPSRASPEFLIGEEDDDLMDVALIGN
Length1574
PositionMiddle
OrganismOpisthocomus hoazin (Hoatzin) (Phasianus hoazin)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Opisthocomiformes> Opisthocomidae> Opisthocomus.
Aromaticity0.05
Grand average of hydropathy-0.651
Instability index54.13
Isoelectric point8.88
Molecular weight167294.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01744
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|    1068.54|     108|     109|    1057|    1164|       1
---------------------------------------------------------------------------
  534-  604 (53.49/ 7.98)	............P.ASSP.......GY....GMTTGsnpmSGTttpT.NTF..PGGPITT............LFNM...S.L...SM...........KERHDSvgH.....................................GED.FS.........KVSQNPILTS..LLQ.ITG
  605-  713 (80.71/15.78)	........SVGSAiGSSP..T...PPHhtppPVSSP....AGN...T.KNHpmLMNLLKE..NPP...QDF..............STL.......YGSSPLERQ..NSSSGSPRMEMGPGGskqKKK.......KSrmpadKPKHQT.ED.........DFQRELFSMD..VDS.QNP
  716-  810 (103.19/22.23)	DVN.MTADTLDTP.HITP..A...PSQ....CSTPP....TTY...P.QPI..P................HSQPSI...Q.R...MVR.......LSSSDSIGA..DVTDILSDIAEEAS....KLP.......TT.....NEDCPPiGT.........PVRDS..SSS..GHS.QSA
  818-  943 (87.03/17.60)	QTN.NSENPYTDP..ADL..I...ADA....AVSPT....SDS...SnHFF..PDG.VDF...NPdllNSQSQ......S.GfgeEYF.......DESSQSGDT..DDFKGYASQALSTLG....VQvlgadggEN.....KFKGSN.QSdtvdfsiiaAASKALGSSDilEHH.SGG
  944- 1036 (110.41/24.30)	QSPlLNTGDLGKE.KSQK..R...VKE....G..NG....SGS...N.MAG..P.G..ID..GKP...GKRSRTPS...SdG...KSK.......EKLPKRKKQ..ETDGKSPSHSSS.NR...PFT.......PP.....ASTG...GS.........K.......SP..G...SSG
 1037- 1132 (152.79/36.45)	RSQ..TPPGVATP....P..I...PKI....TIQ................I..PKGTVTV..GKP...SSHGQYTS...S.G...SVT.......SSSSKSHHS..HSSSSSSSSSSSTSG...KIK.......SS.....KSEGSS.GS.........KMSSSLYSSQ..GGS.SSG
 1133- 1210 (116.03/25.91)	QSK.SSAQSVGKP.GSSP..I...TKH....GLSSG....SGS...T.KMK..PQ.......GKP...SS...L............MN.......PSMSKPN.........ISPSHSRPSG...........................GS........dKLASPMKPVP..GTP.PSS
 1211- 1283 (105.52/22.90)	KAK.S............P..I............SSG....SGG...S.HMS..GSGSSSS..MK....SSSG.MGS...S.G...SM..........SQK...P..PPSSNSSTASSS................SF........SSS.GS.........SMSSS..QNQ..HGS.SKG
 1284- 1366 (89.35/18.26)	KSP.SRNK...KP.SLTA..VidkLKH....GV...........................vtGGP...G..GDDPM...D.G...QMG.......PSSNSSSHT..MSSK.HNMSGGEFQG...KRE.......KS.....DKEKS.............KVSVS.......GGSvDSS
 1367- 1456 (84.80/16.95)	KKN.SDSKNVGST.GVAKiiI...SKH......DGG....SPS...I.KAK.....................................vtlqkpgEGGGDSLRP..QMASSKSYGSPLISG.....S.......TP.....KHERCS.PS.........HSKSPAYTPQ..NID.SES
 1457- 1548 (85.22/17.08)	ES............GSSI..A...EKS....YQNSP....SSD...D.GIR..PLPEYSS..EKH...KKHKKEKKkvkD.K...DRD.......RDRDRDKDR..DKKKSHSMKPESWS......K.......SP.....ISADQS.LS.........MTSSAILSAE.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.66|      65|      98|     167|     236|       2
---------------------------------------------------------------------------
  167-  236 (98.33/75.12)	LALQSLELDlSKMAGMYWQATNANPLDkiLHGSVGYLTPR....SGGLLMNLKyYVSPYDLFeDGTGAPVILHE
  265-  333 (113.33/67.17)	LIMGSHPVD.SKGTPSFSSITSANSVD..LPACFFLKFPRpipvSRAFIQKLQ.GCTGIPLF.DTPPTFVPLYE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.94|      19|      97|     374|     406|       4
---------------------------------------------------------------------------
  374-  393 (30.30/42.33)	LP.DGRSLQGTLISkIAFQHP
  430-  449 (32.63/11.10)	LQfEVCPLSDSCFS.VSFQHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.10|      14|     102|     143|     156|       5
---------------------------------------------------------------------------
  143-  156 (25.28/16.16)	SKHLRGLVNLYKLP
  248-  261 (25.82/16.67)	SVTVEGTMTMYKLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01744 with Med1 domain of Kingdom Metazoa
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