<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01734

Description Mediator of RNA polymerase II transcription subunit 12-like (Fragment)
SequenceQDELTAVNVKQGFSNQPAFSGDEHGSARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGSKPLTLLAKKVPILSKKEDVFAYLAKYSVPLLRAAWLIKMTCAYYAAISEAKIKKRQATDPNIEWTQIITRYLREQLAKVGEFYHVTSSQGNSSVVMPQEMEQALKQWEYNEKLSFYMFQEGMLERHEYLTWILDVLEKIRPTDDDLLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDGPNLVAAHSPHMIIGPSNPPLAAPSPTAPGPVVSPVQLACSDFLSCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKNVNPGSPLDLLQVAPSSLPMPGGNSAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESLSSASLTGSSLPVFQNVLLRFLDTQAPSLSDPNSDHEKIEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSITATTRPRSPNGETVDEHYSKDHDVKLEDHSIMEHMGIDSGTASIFDDVDKSDFKADFGSEFPVVTSEKSVKRERLRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKTKQEAFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNSEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAGRINDIANLCAELTACCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGTGKLFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSNNVNSLKSEDFHMRGLLDELNEDEIWGSSHTLKSCGKTVSIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIKECTEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQVKQAHNHEHLFNWREERYQDDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHTHTKPKPRSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGELSDQGKLATDDEKKTKGRKRKSKSSSRADVSS
Length1778
PositionKinase
OrganismNipponia nippon (Crested ibis) (Ibis nippon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Pelecaniformes> Threskiornithidae> Nipponia.
Aromaticity0.07
Grand average of hydropathy-0.325
Instability index49.00
Isoelectric point6.22
Molecular weight199091.53
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01734
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.71|      18|      27|     844|     862|       1
---------------------------------------------------------------------------
  844-  862 (26.66/22.29)	AELLLKSSSLAGSYtTGLC
  874-  891 (33.05/22.57)	ACLILNSEQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.32|      12|      27|    1105|    1118|       2
---------------------------------------------------------------------------
 1105- 1118 (20.23/19.01)	PGARMTCRllLHLF
 1135- 1146 (24.10/15.15)	PGIRSSCD..RHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     224.72|      72|     148|     504|     578|       3
---------------------------------------------------------------------------
  504-  578 (110.04/77.63)	QAEIEAERCGESEVLDEKESLSSASLTGSSLPVFQNvLLRFLD..TQAPSLSDPNSDHEKIEfvNLVLLFS.....EFTRHD
  647-  725 (114.68/70.82)	KSDFKADFGSEFPVVTSEKSVKRERLRELIFPSNYD.LLRHLQyaTHFPIPLDESSSHECNQ..RMILLYGvgkerDEARHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.43|      28|     148|    1166|    1207|       4
---------------------------------------------------------------------------
  946-  973 (50.42/24.68)	NVQPSNSNLLWDPEF....MLDFIENP....SAHSI
 1172- 1207 (35.02/48.05)	EIGSNNVNSLKSEDFhmrgLLDELNEDeiwgSSHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.99|      26|     148|    1065|    1102|       6
---------------------------------------------------------------------------
  911-  936 (45.69/16.76)	LAYLYDLYVS..CSHLRS.....KFGDLFSSAC
 1066- 1098 (32.30/37.02)	LATFIAILIArqCFSLEDvvqhvALPSLLAAAC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01734 with Med12 domain of Kingdom Metazoa
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