<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01732

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMETQLQSIFEEVVKTEVIEEAFPGMFMDTPEDERTKLISCLGAFRQFWSSLSQESHEQCVQWIVRFIHSQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVVAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAMCNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAHSDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGNMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSLALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPAPLQVFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSRQGSPPLFLCLLWKMLLDTDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMSYHKKYPEKLYFEGLAEQVNPPVQIQPQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEGHLRERTNLKRKLVHAIIGSLKDNRPLGWCLSDTYLKCAMNAREDNPWIPDDTYYCKLIGRLVDNILRKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVINSPSLTSETEWVGYPFQLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLIPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYEMLLNADRCSSHLNYMDPICDFLYHMKYMFTGDSVKDQVEKIICNLRPALKLRLRFITHISKMEPAAVPQQPLSNGSPAQQPSQVPVNVALPVTQ
Length1370
PositionTail
OrganismNipponia nippon (Crested ibis) (Ibis nippon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Pelecaniformes> Threskiornithidae> Nipponia.
Aromaticity0.10
Grand average of hydropathy-0.027
Instability index45.85
Isoelectric point7.43
Molecular weight156974.72
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01732
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.02|      24|      77|     917|     942|       1
---------------------------------------------------------------------------
  917-  942 (42.17/34.41)	WHTKHMSYhkKYPEKLYFEG.LAEQVN
  997- 1021 (41.86/26.85)	FHDRPVTY..LYNTLHYYEGhLRERTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.37|      25|      77|     378|     412|       2
---------------------------------------------------------------------------
  171-  197 (39.44/18.36)	LERNAclLPAYFAVTEIRK.LYPEGK.LP
  384-  410 (35.93/30.81)	IQKNA..LADFLPVMKLFDlLYPEKEcIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.47|      48|      81|     433|     480|       4
---------------------------------------------------------------------------
  433-  480 (82.99/53.71)	NRKAHSDNSKLQIPIP..................HSLKLHHEF.LQQSLRNKSLQMNDYKIAL.LCNA
  495-  562 (59.47/36.30)	LVETIYGNGNMRIPLPgtncmasgsitplpmnllDSLTVHAKMsLIHSIATRVIKLAHAKSSLaLAPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.78|      30|     602|     696|     725|       5
---------------------------------------------------------------------------
  696-  725 (57.08/33.27)	HVTDFFTG...SDSIQGTWC..KDILQTIMSFTPH
 1300- 1334 (44.70/24.62)	HMKYMFTGdsvKDQVEKIICnlRPALKLRLRFITH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.27|      14|      17|    1042|    1058|       6
---------------------------------------------------------------------------
 1042- 1056 (25.22/23.34)	WCLSDTYLkCAMNAR
 1061- 1074 (30.05/14.83)	WIPDDTYY.CKLIGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.94|      34|     602|     207|     248|       7
---------------------------------------------------------------------------
  207-  248 (45.93/55.60)	DF.VDTFRPTARINSIcGRCslLPVVNNsgaMCnsWKLDPTTL
  828-  862 (58.01/37.94)	DFlVYEFSTSAGGQQL.NKC..IEILND...MV..WKYNIVTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.54|      17|     462|     634|     650|      12
---------------------------------------------------------------------------
  634-  650 (31.77/18.96)	PQTNQNQLHL.CVESTAL
 1098- 1115 (27.77/15.63)	PNPAAHALHVtCVELMAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      32|     339|     348|      13
---------------------------------------------------------------------------
  339-  348 (18.69/10.74)	IFFVLFQFAS
  372-  381 (19.45/11.49)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.26|      17|     711|      38|      56|      16
---------------------------------------------------------------------------
   38-   56 (25.86/24.15)	ISCLGA.....FRQfwSSLSQESH
  732-  753 (25.41/14.00)	LSCFPAplqvfFKQ..NNVPQESR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.70|      19|     875|     117|     137|      19
---------------------------------------------------------------------------
  117-  137 (28.17/28.54)	LTFKLVRKIIGGVdyKGVRDL
 1022- 1040 (33.53/24.62)	LKRKLVHAIIGSL..KDNRPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01732 with Med23 domain of Kingdom Metazoa
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