<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01713
Description |
Mediator of RNA polymerase II transcription subunit 1 (Fragment) |
Sequence | ISTDALMEQLRLKYQQKPWTETLKLVHFCMDKPLRRPISNAAGDPLLSCMEKIQRTLNAKSLFSVMNRLESLSKQKGLNVHASPSGTACYITSNMFYIEVQLEKDGNVMDVKLAHLGEAPVVCDDLVQHLRMKNYDAFGKILEDLSNLYQIPGNSEMKAKGYLALQALEKDLYSMSLLDRTQDVNRVTEVLHGKVGHLVPRTGGTPMNIEFYISPYQVLEAELNPGSQVCGTKMVVTVEGTDTLHKLPLSPLLVDSQAGEDSNPAFLPLTDELSMDLPAFFVLKFHQPIPMSSFSIEEIQRLTGIHNLNANKKNHLVSGIQITGLKLAPLYELIVQSTLKEKCSEDLSTHNSCFFVSLPDCPKHCYFINKGSEKSDLAGALVSKIPFSHPKCVPGVIEILRHQVACNSLISSCVSEKHINEDDSELLYFEVVPHKNTSFSVFFLHPLKENLACVIIDVITSREVQCCLHLNPQDPTLNSSDDFIARAMKRCMSVPVVMRAIFRNAAKVKADS |
Length | 512 |
Position | Middle |
Organism | Nipponia nippon (Crested ibis) (Ibis nippon) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda>
Coelurosauria> Aves> Neognathae> Pelecaniformes> Threskiornithidae>
Nipponia.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.094 |
Instability index | 46.69 |
Isoelectric point | 6.33 |
Molecular weight | 57073.45 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP01713
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.47| 25| 119| 86| 113| 5
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86- 113 (40.18/37.18) GTACYITsnmFYI......EVQLEKDGNVMDVKL
204- 234 (41.29/28.64) GTPMNIE...FYIspyqvlEAELNPGSQVCGTKM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 71.21| 23| 79| 238| 260| 6
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238- 260 (40.62/28.03) VEGTD.TLHKL.PLSPLLVDSQAGE
317- 341 (30.59/19.30) VSGIQiTGLKLaPLYELIVQSTLKE
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